I see I made the video in June, 2023, so I would have been 50. But if I had waited a month or two I would have been 51. I didn’t look for the month of the video when I wrote that.
I was essentially 51, but not quite…
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The reason I am including Taurine is because I generate scar tissue (internal)
My body tries to protect me from foreign objects like knee replacement parts, and generates dysregulated fibrotic tissue that restricts range of motion and causes severe SEVERE pain.
Guess what?
Taurine is anti-fibrotic
Good for all
Of you who may end up with fibrosis I heart, lung, or liver tissue. Important to know.
Rapamycun used to cover heart stents to protect them from generating the same tiype of fibrosis
That is actually why I was interested in Rapamycin in the first place - to help me with the fibrotic tissue I generate - called “ Arthrofibrosis”. Now I learn that Taurine is also a help - you can bet I will be taking it!!!
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A lot of that fibrosis can contain senescent cells as well. So, yes, both taurine and Rapamycin should help with that!
A main driver of fibrotic disease is cellular senescence, a state in which cells lose the ability to divide, alter their function, and secrete various pro-inflammatory and bioreactive molecules collectively called the senescence-associated secretory phenotype (SASP) (Hernandez-Segura et al, 2018).
Cellular senescence, p21, and the path to fibrosis - PMC).
We argue that targeting senescent cells , with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.
https://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(24)00134-5
Taurine ameliorates cellular senescence associated with an increased hydrogen sulfide and a decreased hepatokine, IGFBP-1, in CCl4-induced hepatotoxicity in mice
http://www.sciencedirect.com/science/article/pii/S2213231725001533
Thank you for your Taurine information above!! It’s surprising how helpful it is when looked into. I should not have been surprised by the Arthrofibrosis following my first knee replacement. I had experienced a number of fibrotic related type problems when I was younger: Endometriosis, frozen shoulder, and fibrocystic breast disease. An enterprising doctor here in town learned there was practically no iodine in the soil around the Great Lakes, so he conducted a study. When he provided me (and other subjects) with iodine (I think it was the atomic form, but I’m not sure) after about a year, my Endometriosis and my fibrocystic breast disease became much more normal. Unfortunately, he died of cancer, and his work was not promoted by other doctors. After that knee replacement experience, I have included iodine in my supplement list. That is helping with this revision, I think. Thank you again!!! I read all of that information very carefully.
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From that paper.
Nevertheless, the study looked only at natural taurine levels in the body, and not at whether supplements have any benefits. “That’s something that has yet to be tested,” he says (Nir Barzilai).
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Started taking Taurine a few months ago, and in spite of not being able to weight bear for a sustained period (knee revision surgery 3 months ago), my bone density test showed improvement, even though I have mostly forgotten my Residronate because it’s only once a week. Interesting test result!!
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