Nevertheless, the study looked only at natural taurine levels in the body, and not at whether supplements have any benefits. “That’s something that has yet to be tested,” he says.
Ahhh… and for me… think higher supplementation for a year… improved my bone density and gum/teeth health.
I had a hunch that taurine might work synthetically with soluble fiber to lower cholesterol, and asked OpenAI’s o3 model to see whether it was plausible. Here was the result:
Both pieces of the puzzle work separately, and the biochemistry supports a complementary “make more bile acids, then lose them” loop.
However, direct experimental evidence for synergy is still missing. A short, well-controlled human trial with the measurements above could close that gap and clarify whether combining taurine with soluble fibre yields clinically meaningful extra LDL reduction – or whether FXR feedback, conjugation patterns, or GI tolerance limit the payoff.
Thanks Vlasko… my N=1 says I am getting bone density improvement. Based on DEXA score before and with taurine.
@Agetron But weren’t you also taking HGH? That can move the needle quite dramatically re: bone density.
The DEXA better T score was with the only change in my medicine/supplements being taurine a year earlier. January 2024 to November 2024.
Started HGH this January 2025. Certainly it too can help bone density. I will see in the DEXA I take in 1.5 years if even better.
My insurance covers free DEXA every 2 years.
TRT can also help with that. I know you’d already been on testosterone for a few years but it might take a while to show appreciable effects. Not dismissing the taurine connection. Just would love to see a clearer use case without other interventions known to improve bone density.
True… but because I was on on TRT… for 5 years and rapamycin 4 years when first test came back showing osteopenia. I think it is not likely those benefitted to a sudden a change in the past 2 years. Pretty sure it was taurine.
I do more testing than many on this site… 
Not cheap tracking my past 5 years every 4 to 6 months.
Here is the author of the 2023 taurine study chiming in with his take
https://x.com/vijayyadavlab/status/1934680200521904443?s=61
This story is not over. He mentioned they’re conducting a new double blind placebo controlled for half a year.
I took six grams per day for at least six months and noticed a net effect of zero. Whether it helps or not on a subliminal level, it makes me toot like a tuba, which I don’t like.
Hmmm… never heard of it having gastric… gas effects. Unlike acarbose. Lol.
I don’t feel different with Taurine… but DEXA tests say differently. Great improvements.
We are more different than we look it seems.
I have the same reaction. IIRC I determined it’s likely because I was saturating the taurine transporter so taurine was making it to the colon where bacteria love to turn it into hydrogen sulfide. Lower doses spread out might help, but I didn’t try it.
O3
(timestamps, fillers, and repeated words removed; punctuation and paragraphing added for clarity)
Two years ago a breakthrough study suggested that taurine could help combat aging. A new study just published casts serious doubt on that earlier result—and that is a good thing, as I’ll explain.
Taurine is an amino acid found naturally in the body, especially in the brain, heart, and muscles. It plays many roles, from energy metabolism to supporting the nervous system, and deficiency can cause cardiomyopathy. For decades it has been added to energy drinks, but interest in taurine has soared because of its possible influence on aging.
Researchers reported two key findings:
Supplementation effects
Age-related decline
Taurine levels appeared to fall sharply with age in mice and monkeys, and the authors inferred the same for humans.
They concluded that falling taurine drives aging and that supplementation could slow the process.
Other papers had shown conflicting patterns—some found taurine rose with age, others saw no change—so a team re-examined the question.
Result: taurine does not decline with age; if anything it trends upward slightly, and individual variation is far larger than any lifetime change. Taurine levels also failed to correlate reliably with muscle strength, body weight, or other aging markers.
Therefore the central premise of the 2023 paper—that low circulating taurine drives aging—appears wrong, undermining the lifespan-extension hope.
Science advances by proposing, testing, and, when necessary, overturning ideas. The new study illustrates the self-correcting process: doubts about methodology prompted better data, refining our understanding of taurine.
The presenter still takes taurine (as part of “Microvitamin Plus”) but not for anti-aging. Human clinical data—though preliminary—suggests benefits for metabolic syndrome:
Safety data are reassuring; in vitro findings that taurine can fuel growth of existing cancer cells are not evidence of cancer risk in humans.
For now, taurine is probably not an anti-aging panacea, but it may offer cardiovascular and metabolic advantages. The presenter will keep using it while staying open to new evidence.
| Aspect | Strengths | Weaknesses / Caveats |
|---|---|---|
| Explanation | Clear walkthrough of cross-sectional vs longitudinal methods; good analogies (anxiety example). | Could have shown actual figures/tables; relies entirely on narration—visual data would help viewers judge. |
| Balance | Acknowledges excitement and disappointment; emphasizes uncertainty and need for replication. | Nonetheless ends by reaffirming personal use of taurine, which may bias tone (the presenter sells a supplement containing taurine). |
| Evidence appraisal | Properly highlights limitations of meta-analysis (short duration, variable quality) and of in-vitro cancer data. | Does not quantify effect sizes or heterogeneity statistics from the meta-analysis; viewers cannot gauge clinical relevance. |
| Logical flow | Nicely connects new study findings to broader theme of scientific self-correction. | Leaves an open question—why did taurine extend lifespan in animals?—without discussing possible species-specific mechanisms or dosage differences. |
| Conflict of interest | Discloses personal supplement use and that formulas can change. | Would be stronger to state whether the presenter profits directly from Microvitamin sales. |
| Actionable advice | Encourages evidence-based decisions and waiting for better trials. | Could have provided practical guidance on consulting healthcare professionals before supplementing. |
Overall: The video is an accessible, mostly balanced update that punctures hype around taurine and aging while still exploring other possible benefits. The main limitation is potential conflict-of-interest bias—all viewers should interpret the endorsement of continued taurine use in that light and await larger, longer human trials before drawing firm conclusions.
Yes, that’s a good summary. In essence, taurine does not decline with age as first thought, but it is still an excellent supplement for metabolic issues.
It also prevents the formation of senescent cells in mice.
As I interpret the new data. If a person is deficient in taurine, then the odds are good for an improved health and longevity, if they supplement with taurine.
I have reduced my intake to approximately 2,5 grams if I wake up during the night.
2-2,5 grams is great for putting me back to sleep, when I wake up at 3 AM (which is often). Some days I also take 2,5 grams in the the morning. So all together, I am down to approximately 2,5 - 5 gr per day.
You don’t know for sure how old you were in 2023? 
sorry had to say it lol but thanks for the info on Taurine. I’ve experienced some benefits from taurine also but mine had mainly to do with stomach issues and heartburn. Taurine totally fixed it. I don’t know if it does anything for longevity but taurine is one of very few sups that intend to take it for life, since I’ve had stomach/acid reflux issue for as long as i can remember and as soon as I started Taurine my problems just disappeared.
I see I made the video in June, 2023, so I would have been 50. But if I had waited a month or two I would have been 51. I didn’t look for the month of the video when I wrote that.
I was essentially 51, but not quite…
The reason I am including Taurine is because I generate scar tissue (internal)
My body tries to protect me from foreign objects like knee replacement parts, and generates dysregulated fibrotic tissue that restricts range of motion and causes severe SEVERE pain.
Guess what?
Taurine is anti-fibrotic
Good for all
Of you who may end up with fibrosis I heart, lung, or liver tissue. Important to know.
Rapamycun used to cover heart stents to protect them from generating the same tiype of fibrosis
That is actually why I was interested in Rapamycin in the first place - to help me with the fibrotic tissue I generate - called “ Arthrofibrosis”. Now I learn that Taurine is also a help - you can bet I will be taking it!!!
A lot of that fibrosis can contain senescent cells as well. So, yes, both taurine and Rapamycin should help with that!
A main driver of fibrotic disease is cellular senescence, a state in which cells lose the ability to divide, alter their function, and secrete various pro-inflammatory and bioreactive molecules collectively called the senescence-associated secretory phenotype (SASP) (Hernandez-Segura et al, 2018).
Cellular senescence, p21, and the path to fibrosis - PMC).
We argue that targeting senescent cells , with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.
https://www.cell.com/trends/molecular-medicine/abstract/S1471-4914(24)00134-5
http://www.sciencedirect.com/science/article/pii/S2213231725001533