Any benefits drawback to taking my Rapamycin on an empty stomach? I’ve been taking my dose at right after dinner. I usually eat OMAD or one meal a day and dinner it is. Also, just wondering if perhaps the MTOR effect is blunted or enhanced based on feeding state? Just curious what everyone thoughts are?
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Not really, just that you might be missing a 30 percentage boost in bioavailability if taken with a fatty meal (I take it with sardines, other people here do a shot of olive oil)
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Would cooking with butter suffice?
Edit: Thank you on Bioavailability. I did not know this!
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I don’t know exactly how much fat is required to increase bioavailability… You may want to review this paper: The Effect of a High-Fat Meal on the Oral Bioavailability of the Immunosuppressant Sirolimus (Rapamycin)
Full paper here: Sci-Hub | | 10.1177/009127009903901107
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