Get a standard blood test. Your doctor will have to order this blood test for you. This will test for ALP, along with a number of other enzymes that help indicate your overall level of health. If you have concerns regarding your ALP levels due to malnutrition or a pre-existing condition, ask your doctor about getting a standard blood test.
Intestinal alkaline Phosphatase is increased by butyrate or vitamin K1 (~1500mcg/day). Butyrate comes from great prebiotics like inulin or dandilion or chikory root. Also acarbose and alpha cyclodextrin. Thats Intestinal AP, in the blood stream AP follows the level of LPS and more is not better. You want low numbers here.
Wow the timing of this thread couldn’t have come at a better time.
I’ve been struggling with low Alkaline Phosphatase for years. Blood tests show a level between 40-50 depending on the day I get it checked. Technically, 40 is the bottom of the range but clearly I want it higher.
Is this a supplement or drug I can access online or is it some new thing that will be impossible for me to get?
Ingested ALPI won’t cross the into the blood in significant quantities – it’s also a slightly different protein than you’re talking about. Injecting human proteins is a whole different – and expensive – ball game.
You want low ALP. 50 is perfect, it’s what mine was when I was 50. Now mine is more like 85. The older you get the higher it goes. Low ALP indicates low LPS, or a low microbial burden. You’re doing great.
I should be looking for supplemental IAP, not you.
I don’t think Michael Lustgarten puts too much weight on any particular test, and the majority of the information is about observational studies, not RCTs. BTW can you point to his video about ALT?
The graph you point to is based on an observational study only.
“Age and sex variation in serum albumin concentration: an observational study”
Sorry, I think I saw that here too not that long ago but can’t find it now.
I don’t know for sure but I like that he sticks his neck out a bit and tells the reader what he thinks based on observational studies. I learned a great deal from his book and even if it’s wrong at least I know the characters a little better. LPS, ALP, CD38,NAD, LL-37. That article you pointed to said they don’t know what it does. He says if you work on barrier function and reduce microbial burden it will go down. Anything over 48 is bad. So at least I have an idea what to do.
It’s fine to want to adjust all of our health parameters to the best possible levels, but ALT is not high on my list.
As you can see ALT isn’t even on the Levine-based age spreadsheet calculator.
Also, ALT is not found as one of the parameters on the Aging.Ai, 19 parameter input calculator.
(As, a side note: Why I am not big on CRP measurements unless you are sick and it is being used to help with a diagnosis) “C-reactive protein value can change by orders of magnitude in the presence of a wound or infection.”
FWIW, (Maybe, posted before?):
Ranking the influences in order as calculated by @JGC Retired Professor of Physics 4 yrs ago.
ALT is alanine transaminase, not to be confused with ALP alkyline phosphatase. Alkyline Phosphatase is in the levine calculator. And I don’t really understand the list you put out but it looks like it’s worth more than CRP.