Don’t know enough but your blood test might be different from what you want in your micro biome
See et this
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Anyone have any experience on whether the peptide BPC157 might help ALP with fighting leaky gut?
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You’re sure about this? My recent result was 40 and flagged as LOW. I read deficiencies in magnesium and/or zinc could cause that, even though I consume plenty of both.
I’m not a doctor. I read about this in Michael Lustgarten’s excellent book “Microbial Burden and what you can do about it”. I’m sure the microbial burden is not the only thing that affects AP. Google lists protein deficiency and a couple diseases as well. If these things are ruled out then that leaves really good news about your microbial burden.
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Update, I asked him and this was his response
“< 48 for ALP is associated with lowest all-cause mortality risk, so you’re likely good there
So thank you for bringing it to my attention @Bicep . I’m not so worried anymore
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Have you tried supplementing with these? It looks like one of the safest approaches right now in terms of longevity.
I was hoping someone had tried with available current IALP:
Unfortunately, it appears that Synthetic Biologics (now Theriva Biologics) has abandoned further work on this asse. It’s not currently listed in their pipeline, and a press release from November mentions " lower expenses related to our Phase 1a clinical trial of SYN-020 which has completed".
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An update to this thread. This article from 2024 brings forward the theoretical framework that challenges the mainstream theory of ageing. For those not familiar with the term “smurf” in ageing - they have found that when flies are fed with food that contains a blue dye, then 2–3 days before the death, the fly turns blue. Therefore, the name smurf. This smurf phenotype is due to the breakdown of the intestinal barrier, a leaky gut. They don’t say that “leaky gut” is causative of an impeding death, but there is a very strong correlation between the smurf phenotype and an imminent death. Now they try to find signals that precede the smurf phenotype.
"It is demonstrated that the smurf phenotype is a harbinger of death across species, allowing for the identification of individuals about to die from natural conditions 2–3 days prior to death. As time passes for a non-Smurf, its gene expression becomes noisier until it reaches a point—an hypothetical “Smurf Transition Point” yet to be characterized—at which individuals undergo an abrupt modification of the transcriptome, reminiscent of the “transcription hallmarks of ageing” leading to a general stereotyped collapse "
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How unfortunate. I’ve never managed to even get mine into the reference range in as long as I’ve been checking. No amount of magnesium or zinc helps. It’s very perplexing. I am truly at a loss as to why my ALP is always so low.
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It’s kind of cheating I know, but TUDCA will fix that. I was only taking it a few times a week and it dropped 40 points.
The article is talking about Intestinal Alkaline Phosphatase, you are talking about serum Alkaline Phosphatase. They are really different!
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Oops sorry I was skimming
Thanks for letting me know there is a distinction. I was not aware!
I have always had low serum ALP and have never been able to figure out if that’s a problem/concern or not. If you learn anything more please share!
My understanding is that low serum ALP is good. This study shows lower is better and all the way down:
https://sci-hub.ru/https://doi.org/10.1093/ije/dyt192
I use this when I want to know what’s good in lab values:
https://biomarkeroptimizers.com/tools/test-results-analyzer/
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Skim Milk Culture of Lactobacillus johnsonii SBT0309 Increases Intestinal Alkaline Phosphatase Activity and Inhibits Lipopolysaccharide-Induced Interleukin-8 Production in Intestinal Epithelial Cells
https://www.mdpi.com/2073-4409/14/5/358
It’s a little bit expensive the supplement but I imagine that once a colony of Lactobacillus has installed in your gut, it should help your entire life, right?
Edit: Lactobacillus is consider a transient microorganism and requires constant supplementation to persist. So, monetary wise, it may be better to just take intestinal alkaline phosphatase.
Give it a go and tell us what happens.
That depends on how well it grows in warm milk. Some cultures, if fed just a little inulin or potato starch can multiply thousands of times even millions and make delicious yogurt. You could pay quite a bit for a good sample and maybe use it for a very long time. Maybe not, depending on how well it grows. I couldn’t find that particular strain, Plenty of johnsonii, but not SBT0309. Have to keep looking.
For some people this is important, IAP is key. I have the SNP’s for crohns and my brother has it full on so I should be doing all I can.
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Also SBT0309 is a proprietary strain developed by MEGMILK SNOW BRAND Co., Ltd., and it’s not currently available in commercial probiotic products.