Did inhibition of DREAM complex decreased the number of somatic mutations and increased the lifespan of naturally aged C Elegans?
I’ve seen video where someone tried to overexpress different DNA repair mechanisms in human cells and in 95% of cases, DNA repair was worse. And DNA repair is only one hallmark of aging
Also, DNA repair isn’t always as straightforward - some animals have 10 000 more resistance to some types of DNA damage (UV radiation) and still live shorter than humans
Tardigrades are characterized by extreme tolerance to radiation-induced DNA damage [38.]. These aquatic animals, also referred to as water bears, protect their DNA by a chromatin factor, damage suppressor (Dsup), and expression of this protein is sufficient to boost radiation resistance also in human cells in culture [39.]. However, expression of Dsup in cortical neurons cultured from rat embryos showed induction of double-strand breaks and cytotoxicity, indicating that translating such approaches might not be straightforward