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Thanks for the response!
Over the last eighteen months I’ve lost 150 LBS. using a GLP-1 (Tirzepatide). As for diet, I follow a mediterranean diet.
I don’t follow a low sodium diet, as low sodium diets have largely been debunked and have been associated with a marketed increase in ASCVD;
I do approximately ninety minutes of Zone Two cardio/day with occasional slips into HIIT. I also weight train three times a week.
ApoB: >90
LDL - >80
In fairness to my stats, I also use Lisdexamphetamine (Vyvanse) daily for ADHD and do TRT for low Testosterone.
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I have noticed a small decrease in my Maximum Heart Rate. I’ll do some research on increased risk factors with a lower maximum heart rate outside of cardio training.
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Really interesting, thank you for sharing much appreciated 
I am trying to increase my ‘heart rate variability’.
Doing:
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Pranayama Yoga breathing exercise (Pranayama to Cool your Body | Follow Along Sheetali & Sheetkari Pranayama | SRMD Yoga - YouTube),
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Yoga Nidra ( Advanced Yoga Nidra Meditation For Restful Sleep & Relaxation | Non-Sleep Deep Rest (NSDR) - YouTube)
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sauna/whole-body-cryotherapy.
What would be great is if this simple pharmacological intervention could increase HRV?
These β1 selective adrenergic receptor antagonist seem to increase HRV. My interest is well and truly sparked!!!
Overall, the administration of each β -blocker led to directionally similar increases in the HRV variables, which were most significant following 100 mg atenolol.
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Yes! Actually they tested it in the 2020 cohort, but I haven’t seen any updates on that batch.
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The most important aspects of nebivolol that distinguish it from older beta-blockers are its vasodilating properties (prevents sexual dysfunction associated with other b-blockers) and the fact that it stimulates B3 receptors (beta 3 agonist) which prevents the negative metabolic effects seen with older beta blockers. It really is an amazing medication that is unfortunately SO under-prescribed because most clinicians are simply ignorant of its advantages over the old b-blockers. It recently went generic, so it’s even more of a shame that it’s still so under-prescribed. I’ve been taking it for hypertension for the past 15 years or so.
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That’s just an assosciation and doesn’t debunk the case for sodium restriction based on causal evidence.
Low sodium diets lower blood pressure, decrease rates of stroke, cardiovascular disease and death. If you are a strong responder it might decrease BP by a lot.
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Spindler showed life extension in mice. (This fact was mentioned in several posts above, I’m just adding a direct link to the primary source.)
A different design showed no life extension from atenolol in mice.
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I’ve been on 5mg Nebivolol for five years. Extremely pivotal drug in my lifespan extension protocol for lowering blood pressure and heart rate
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I think it’s important to differentiate between something that is providing a medical outcome (i.e., mgmt of HTN) vs something that may have wider applicability through a longevity “stack” (the world at large would benefit from a lower bp but at the healthy individual level, I’m not too sure.
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I’d be curious to see a data sample of users who had HBP and a normal HR, considering 70% of Americans will experience HBP at some point in their lives.
The study below says, that in the elderly, there is an increased risk of stroke with the use of beta blockers.
The lack of effectiveness at lowering central blood pressure may be exacerbated in patients with elevated PWV (pulse wave velocities) [[23] Heart Rate and Blood Pressure: Any Possible Implications for Management of Hypertension? - PMC)]. This interaction may explain the increased risk for stroke associated with beta-blockers in the elderly, a group with elevated PWV, and the opposite effect in younger subjects with normal PWV
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Unfortunately the studies I’ve seen that highlight potential negatives of “beta blockers” do not even consider that nebivolol has unique effects that may exclude it, specifically its vasodilating properties, as in the following study which shows it reduces central aortic pressure and stiffness:
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Correct, Nebivolol is a highly selective Beta Blocker acting almost exclusively on receptors in the heart.
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Not just the heart, but the peripheral vasculature as well (vasodilating effects via nitric oxide) and as a beta 3 agonist, other potential non-vascular benefits as well.
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Yes, and the side effects that are often stated with other beta blockers like worse stamina and erectile dysfunction do not happen with Nebivolol
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I take Ramipril to lower blood pressure and have recently added the beta blocker propranolol in order to lower my resting heart rate. Despite doing regular cardio since I was a teenager (I’m now 65) and following a routine of Zone 2 cardio for 45 min x 3 times a week and Zone 5 HIIT for 10 min x 3 times a week, my resting heart rate was high at 70 to 80 BPM. My Oura ring showed a low sleeping heart rate in the high 60s. When I meditate with deep breathing, my heart rate goes up typically 10 BPM. The propranolol has lowered my RHR to about 10 BPM. I have a mild essential tremor in my left hand and propranolol is on-label treatment for that so I could get a prescription. I haven’t noticed a decrease in exercise performance since taking it. My HIIT workout involves sprinting up stairs and my heart rate goes to 160 BPM when I do that. Propranolol is used as part of desensitization therapy for phobias and a PED for athletes involved in sports that require a steady hand such as archery. Although Nebivolol than propranolol sounds like it might be a better options. Any thoughts?
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What is your propranolol dose?