I would like to see L-Carnosine tested by ITP. Well known anti aging supplement, Mtor inhibitor and it seems like it works much like Rapamycin in anti tumor effects.
If it can be proven to me as effective as Rapamycin or slightly less, it would be a great alternative as it is a supplement and widely available. Rapamycin can be hard to get depending on where you live.
This is a paper from 2014 which I find very interesting.
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Selegeline
White Willow Bark (cleaner, safer version of aspirin that could end up being the top anti aging supplement The Most Potent Life Extension Substance Ever - Rogue Health and Fitness | P.D. Mangan )
DHEA
Pregnenolone
Thank you. Back to citrulline dosing for me.
From your citation above.
L-citrulline is a natural amino acid that is simply available in watermelon juice and rind (Rimando & Perkins-Veazie, 2005). The benefits of L-citrulline in diabetes are through supporting the cardiovascular system by enhancing NO and by inhibiting excessive arginase activation, further augmenting production of NO through providing more L-arginine for the NOS pathway. Others have reported that L-citrulline possesses an inhibitory effect on arginase and have beneficial effects on enhancing organ perfusion and arginine availability under conditions with enhanced arginase activity (Romero et al., 2006).
Like always, it is a question of finding the correct dose. 2000 mg did a good job on diabetic patients. I stay below that
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Oh, by the way - these IGF-1 Blocking drugs should be tested by the ITP program (apologies if its already been mentioned - though its injection, so they probably won’t do it):
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FOXO4-DRI is an obvious one for me. It’s a selective senolytic which has had some biohacker interest for some time now: Experiences with FOXO4-DRI | FOXO4-DRI
It’s strange how I could find no mention of it on this site.
I had ChatGPT help me out with this write-up on 2-DG but the facts are solid:
Recently, while exploring the topic of potential life-extension substances, the AI ChatGPT mentioned 2-DG (2-Deoxy-D-glucose). This piqued my interest and led me to dig a little deeper into this compound. However, I discovered that despite its potential, it possesses cardiotoxic properties which make it a less viable option for life extension.
It’s been approved as an emergency adjunct therapy for COVID-19 in India, despite its known cardiotoxicity. This highlights its unique properties and potential therapeutic applications.
Functionally, 2-DG is a glycolysis inhibitor. For reasons not entirely understood, it appears to inhibit cell growth, acting as a caloric restriction mimetic. This intriguing property slows the heart rate and increases resistance to stress and toxins. Consequently, it has gained attention for potential applications in treating tumors.
The topic of anti-aging is a rapidly evolving field. To put things into perspective, a 2006 article in Scientific American referred to 2-DG as the most promising anti-aging drug. This was at a time when resveratrol and growth hormones were the talk of the town.
While 2-DG is indeed intriguing, its cardiotoxicity presents a significant hurdle for its use in life-extension studies. Interestingly, although it didn’t extend the maximum lifespan of mice in experiments, it reduced mortality in the first half of their lifespan without shortening their overall lifespan.
In conclusion, while 2-DG may not be the key to life extension we might hope for due to its cardiotoxicity, its unique properties and potential therapeutic uses continue to make it a topic of interest in scientific circles.
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Looked into this– sadly not in oral form.
I don’t think Bryan Johnson agrees with these drugs lol
https://twitter.com/bryan_johnson/status/1662146481846120448?s=20
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My understanding is just that he wants it to go up temporarily to regenerate his thymus.
The thymus regeneration approach that Greg Fahey is doing (that Bryan is following i think) is only using growth hormone in a pulsed, short term approach i believe, so its not a lifespan issue.
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I think he has them using it for I want to say two years? In the latest TRIIM X trial I believe. I don’t recall him saying he thinks people should come off.
The brand linked from the blueprint is low molecular weight.
I have been taking high molecular weight from donotage. Very difficult to say if it’s had any effect on my joints. I think rapa had more of an immediate effect in that regards.
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Another candidate - HMB, a bodybuilding supplement, has been found to protect against cognitive decline in mice.
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I’ve just started taking taurine. I take it in small doses throughout the day. By mixing it into my family jar of Kool aid. That way it’s a small consistent dosage. Maybe it will accumulate in the system better. It also ensures that hubby gets it. He has issues with pills and is kinda picky. I also have magnesium, vitamin c and niacinamide in it as well. I’m taking Rapa for fertility help. During the first few days of my monthly cycle.
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me as well. of all the (great) suggestions here i am probably going to write one up about this one since it’s such a low hanging fruit
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The current list of drugs & supplements the ITP is testing:
| Compound | Cohort | Concentration in Food | Age at Treatment Initiation | Increase in Median (Med) and Maximum (Max) Lifespan |
|---|---|---|---|---|
| Hydrogen Sulfide prodrug SG1002 | 2019 | 240 ppm | 6 mo | In Progress |
| — | — | — | — | — |
| 16 alpha-hydroxyestradiol | 2020 | 5 ppm | 12 mo | In Progress |
| 2,4-Dinitrophenol (DNP) | 2020 | 3 ppm | 6 mo | In Progress |
| Hydralazine | 2020 | 30 ppm | 6 mo | In Progress |
| Hydralazine | 2020 | 30 ppm | 16 mo | In Progress |
| Nebivolol | 2020 | 60 ppm | 6 mo | In Progress |
| Sodium Thiosulfate (STS) | 2020 | 10,000 ppm | 6 mo | In Progress |
| Canagliflozin (Cana) - Stage II | 2020 | 180 ppm | 16 mo | In Progress |
| alpha-ketoglutarate (AKG) | 2020 | 20,000 ppm | 18 mo | In Progress |
| 2BAct (2BA) | 2021 | 30 ppm | 7 mo | In Progress |
| Dichloroacetate (DCA) | 2021 | 30 ppm | 7 mo | In Progress |
| Epicatechin (Epi) | 2021 | 60 ppm | 7 mo | In Progress |
| Forskolin (For) | 2021 | 5 ppm | 7 mo | In Progress |
| Halofuginone (Hal) | 2021 | 0.6 ppm | 7 mo | In Progress |
| MSDC-160 (M160) | 2021 | 300 ppm | 7 mo | In Progress |
| alpha-ketoglutarate (AKG) | 2022 | 20,000 ppm | 7 mo | In Progress |
| Atorvastatin + Telmisartan (AtorTel) | 2022 | Ator: 120 ppm; Tel:30 ppm | 7 mo | In Progress |
| Metformin + Nicotinamide Riboside (Met + NR) | 2022 | Met: 1000 ppm; NR: 2400 ppm | 20 mo | In Progress |
| Methotrexate | 2022 | 0.2 ppm | 14 mo | In Progress |
| Mifepristone (Mife) | 2022 | 30 ppm | 7 mo | In Progress |
| Pioglitazone (Pio) | 2022 | 100 ppm | 7 mo | In Progress |
| Captopril (Capt) | 2022 | TBD | TBD | In Progress |
| Meclizine (Mec) | 2022 | 2400 ppm | 16 mo | In Progress |
| Meclizine (Mec) - Males only | 2022 | 800 ppm | 16 mo | In Progress |
| Astaxanthin (Asta) | 2022 | 800 ppm | 11 mo | In Progress |
| Astaxanthin (Asta) - Males only | 2022 | 800 ppm | 16 mo | In Progress |
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When will this batch be reported?
Curious about Pioglitazone.
Haven’t they done Astaxanthin?
I forget the exact timeline - and of course it partly depends on how long the mice live… but I think its 3 to 4 years typically (from start date). But results trickle out after the mid-way point, at academic conferences and in press interviews before the papers are finally published.
Yes - they have done / are doing Astazanthin at 4000 ppm (12% median lifespan improvement for males, not sure on females off the top of my head), but I don’t believe the paper is out yet.
They are doing more Astazanthin tests to see if a lower dosing (more likely to be achievable by humans, given cost and dosing standards of astazanthin in humans), at 800ppm.
https://www.nia.nih.gov/research/dab/interventions-testing-program-itp/supported-interventions
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One thing I find interesting is that the AKG dose (which they typically arrive at by discussing with the leading researchers on that compound (ie. likely Brian Kennedy for AKG), is 20,000ppm, which is something around 15 grams a day in human terms. A very high dose. Also - I wonder what version of AKG they are using - is it Ca-AKG or something else?
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