Curious if you’re following some idiosyncratic strategies? On my end, I used to microdose semaglutide and now I microdose trizepatide (up to 2.5mg). When traveling I use rybelsus. But reconsidering how to go about this lately – perhaps retatrutide for cutting and trizepatide for maintaining.
But what are y’all doing? I did wonder if there’s a role for using the different GLP-1 agonists for different purposes.
My LLM-based “research” suggests here’s what each of them are best in-class for:
Retatrutide:
- weight loss,
- reductions in visceral fat/ liver fat
- reduction in inflammation in the liver
- overall inflammation
- also increases energy expenditure (due to Glucagon mechanism)
- increase in brown fat
NOTE: increases resting heart rate the most, due to sympathetic nervous system activation (also more side effects at the highest dose – sensitive skin, nausea
Trizepatide:
- best improvements in HbA1C / Glucose metabolism
- reduction in adipose tissue inflammation (GIP is abundant in fat cells)
- slight increase in metabolism compared to semaglutide (increased fat oxidation)
Semaglutide:
(mainly because trials are still ongoing for other GLP-1s)
- Renal & Cardiovascular protection,
- reduction in knee arhritis pain,
- cartilage growth
- reducing alcohol consumption
NOTE: fatigue is a more common side effect here.
Exenatide
- in Parkinson’s (slowing motor decline)
- crosses the BBB
Liraglutide
- crosses the BBB
- promising for cognitive aspects
- promise for Parkinson’s