Admittedly, this topic isn’t my strength, but would low dose adderall possibly be the best anti depressant? They make people happier. I saw Cremieux posted about adderall being an anti depressant on X yesterday.
1 Like
Not an SSRI but comparable: Saffron is totally worth a shot. Might be the most evidence based dietary supplement for depression.
https://www.sciencedirect.com/science/article/abs/pii/S0165032717315884
It could be for many people. Dopamine, noradrenaline, and serotonin are the big 3 neurotransmitters for mood, depression, adhd etc.
Someone here did post something like this to you in a thread you made.
1 Like
Go to Oregon and do 1-2 psilocybin 4-5 mg trips in a guided setting with follow up counseling. It will most likely cure the depression for 2+3 years if not longer. No SSRIs needed.
2 Likes
Have you or others you know done this?
Yes. PM me if you’d like to know more.
One would have to pay me upwards of $1billion dollars to try any of these categories of drugs. Why risk getting effed up for life when you could have amazing results from 50-100mg modafinil with no side effects and no withdrawal symptoms. Nah too dangerous to play with. Might as well get a king cobra as a pet LOL:
Yea I never really thought SSRI’s were worth it. I’ve never personally used one so if someone says it changed their lives for the better, then good for you.I could see something like Wellbutrin making more sense than an SSRI and would put that more into the modafinil category since there doesn’t seem to be much of a withdrawal risk. I actually plan on trying that to see how I feel on it.
The problem with modafinil for me at least is that I build tolerance to it rather quickly, and it causes small increases in heart rate and systolic blood pressure. Not to mention occasional insomnia.
2 Likes
Well I am relatively new last 10 days or so but it is amazing. The building of tolerance I could probably see it but i think if you stay couple days off you’re good to go again. I didn’t take any yesterday just to test and took today 1/2=100mg and it’s like night and day. As far as the increases in HR and BP I honestly don’t care given how good it makes me feel, totally worth it. Plus, I happened to be in a good spot with BP I’m usually low anyway 105-110/70-75 and an increase to say 120-125/80 I don’t think I would mind. However, I haven’t experienced and increase in BP nor HR that I can notice in last 10 days (since I started).
As far as sleep, boy o boy am I ever happy I found them both (modafinil and selegiline). I’ve been tortured for last 2-3 years with barely 5 hours sleep nights and in last 2 weeks (when I started both Selegiline and modafinil) I’ve averaged over 7 hours straight. I do take them first thing in the morning though. I don’t think I’d take modafinil after AM. As far selegiline I’ve taken it couple times around 2PM and it did not adversely affect my sleep even taking it that late. Modafinil though it feels different and I’m sure it would interfere with sleep if taken in the afternoon.
fyi- I’m loading up on it nicely. Just placed an order of 600 200mgs today in addition to about 800 I already have, I think it is an absolute must have for everyone.
2 Likes
Idk when it turns into a waking dream or you go in a loop, it wrecks the therapeutic effect
I don’t disendorse psychedelics, but too many people advising me to do psychedelics did contribute to me getting into “weird situations” under them and my brain is more SEBUS-prone than most
The psychedelic with the lowest downside risk is DMT, esp b/c it lasts so quickly ( it’s also so intense you don’t end up doing dumb things outside or post to social media while on it). Plus you can legally do it in Colorado
I once helped host a DMT party and it cured one person’s trauma
==
I think SSRis have a bad rap because they “dull your sense-making apparatus”/constrain the brain’s dynamic repertoire and it’s overall healthier to see it all and be completely unmoved/untriggered by it which is what advanced meditation/jhana tries to do, but not everyone can meditate/jhana so the biggest ROI move is often 5-MeO-DMT (which is also short enough that people don’t do dumb/antisocial things on it like they might with psychedelics)
Saffron does work to reduce depression as my friend started it and there really was improvement in about four weeks.
1 Like
Do you mean buying them from India?
I think it does a little too. The evidence is there IMO. Been taking 30mg with breakfast and another 30mg before bed (helps with sleep too).
yes. twenty characters
It’s interesting you should mention buproprion. I am trying that now (75 mg SR - low dose) to see if it could replace or benefit modafinil. Yes, tolerance to Modafinil builds rapidly and periodic breaks for me seem to be very important. So, maybe buproprion will be beneficial? Unfortunately, from my research it could take a few weeks to see an effect, very much unlike Modafinil.
1 Like
I have had the same thought process as you and managed to get a prescription today for 150mg so I will probably start it in the next few days once I get a hold of it.
One issue is it’s contraindicated with Selegiline even thought I only take 2.5mg so I might have to stop taking that unfortunately
LukeMV, I hope you find good results with buproprion. After only one week I’ve decided to stop it. It seems to bring my mood down in the afternoons consistently and that seems contradictory to what it should do.
1 Like
Ouch, i’m hoping that doesn’t happen to me. Were you taking the XR version? What dose?
75 mg SR - low dose. Who knows why it didn’t quite work? Maybe it should have been a higher dose XL version for extended release to avoid peaks and dips. Whatever the case it’s easy to stop this low dose.
I was given 150mg XR to try