I know Chris Masterjohn compiled a master list lately on their effects on mitochondria, and from everything I’ve seen so far, Prozac seems least risky (doesn’t seem to activate dementia like other SSRIs), and is mildly activating. On longevity, it could go any direction, but [from everything I’ve read] Prozac seems very very mildly pro-longevity, more than any of the other SSRis
I’ve had bad experiences with two SSRIs in the past but don’t know why i asked for those two SSRIs when I could have asked for Prozac instead.
I’ve heard good reviews of zoloft too (esp b/c my life is a constant struggle with energy), but it was recently implicated in a dementia study