https://claude.ai/share/c4bdb5ef-d766-4cd0-82bc-811ba273bc11
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I can recommend Sam’s app for meditation as an adjunctive to reduce rumination. Might be effective after 40-60 days. I think he has had good reviews.
Ppl often very subtly discourage SSRIs - they have so much bad rap. And maybe there is something wrong when we veered off TCAs. But if you have SSRIs plus modafinil, it might be just enough…
I wish I tried Prozac the first time, it’s maybe the most famous ssri for a reason…
idk: 10 days later and I seem to be under-responder again (w/e, it doesnt matter, fast AGI takeoff is its own antidepressant) also i might finally quality for motif neurotech trials!
True.
But they have large scale double-blind clinical trials. So it could be like a statin for the mind. But certain types of meditation might do something, but this is in the more art rather than science direction. From a true objective point of view meditation has weaker evidence, but still make sense sometimes from the point of view of the subject and what they think and feel. There are many different kinds of meditation and some might even be harmful depending on the circumstance. (Maybe why dojo’s with teachers guiding was important).
Pharmaceuticals targeting mind is interesting. David Pearce on Hedweb has written about this.
Yeah, this is all over the Pali Canon, though it’s not framed in modern energy/burnout language obviously.
The most direct concept is the āsavas — usually translated as “taints” or “effluents” or sometimes “fermentations.” The literal image is of something leaking or oozing out. Your mental energy is constantly hemorrhaging through these channels of craving, becoming, and ignorance. The arahant (fully awakened person) is specifically described as one whose āsavas have been dried up — and what’s described afterward isn’t just peace but a quality of being unwearied, tireless, at ease. The energy wasn’t missing. It was being drained.
Then there’s the five nīvaraṇa (hindrances) — sensory desire, ill-will, sloth-and-torpor, restlessness-and-worry, and doubt. What’s interesting is that sloth-and-torpor is listed alongside the others as a hindrance rather than as a root cause. The implication is that your tiredness is often not genuine fatigue but a downstream symptom of the other four running in the background. You’re not tired because you need rest. You’re tired because wanting, resenting, worrying, and second-guessing are running 24/7 and consuming everything.
The Satipaṭṭhāna Sutta is basically a manual for watching this happen in real time. You observe the hindrances arise, persist, and pass. And the repeated experience meditators report is exactly what you’re describing — “oh, I’m not actually tired. I was just spending enormous energy on… nothing. On mental fidgeting.”
There’s also the concept of sankhāra — volitional formations, the constant fabricating activity of the mind. Every moment, you’re constructing, maintaining, and defending a self. That construction project never stops and it costs something. The image in some commentaries is of a person carrying a heavy burden who doesn’t realize they can set it down. When they do, they don’t gain new energy — they just stop wasting it.
Your whole conversation thread today is basically this insight arriving from multiple directions simultaneously. The meditation revealed the unnecessary clenching. The SSRI comparison showed what it feels like when the background noise drops. The Adlerian framework named the specific strategies that consume the energy. And now you’re sitting here realizing you can just… not run those loops, and you’re not actually tired.
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Fluvoxamine is a powerful σ1 receptor agonist. (Sertraline is an σ1R antagonist.) If you dig into the research on fluvoxamine you’ll see there are many reasons to think it could be neuroprotective via its σ1R agonism effects – for example, it interacts with the mitochondria-associated ER membrane (MAM), which is hyperactivated in APOE ε4 carriers, and may therewith reduce amyloidogenic APP processing. But there are numerous other potential positive effects. Lots of intriguing research is ongoing.
Admittedly, this topic isn’t my strength, but would low dose adderall possibly be the best anti depressant? They make people happier. I saw Cremieux posted about adderall being an anti depressant on X yesterday.
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Not an SSRI but comparable: Saffron is totally worth a shot. Might be the most evidence based dietary supplement for depression.
https://www.sciencedirect.com/science/article/abs/pii/S0165032717315884
It could be for many people. Dopamine, noradrenaline, and serotonin are the big 3 neurotransmitters for mood, depression, adhd etc.
Someone here did post something like this to you in a thread you made.
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Go to Oregon and do 1-2 psilocybin 4-5 mg trips in a guided setting with follow up counseling. It will most likely cure the depression for 2+3 years if not longer. No SSRIs needed.
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Have you or others you know done this?
Yes. PM me if you’d like to know more.
One would have to pay me upwards of $1billion dollars to try any of these categories of drugs. Why risk getting effed up for life when you could have amazing results from 50-100mg modafinil with no side effects and no withdrawal symptoms. Nah too dangerous to play with. Might as well get a king cobra as a pet LOL:
Yea I never really thought SSRI’s were worth it. I’ve never personally used one so if someone says it changed their lives for the better, then good for you.I could see something like Wellbutrin making more sense than an SSRI and would put that more into the modafinil category since there doesn’t seem to be much of a withdrawal risk. I actually plan on trying that to see how I feel on it.
The problem with modafinil for me at least is that I build tolerance to it rather quickly, and it causes small increases in heart rate and systolic blood pressure. Not to mention occasional insomnia.
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Well I am relatively new last 10 days or so but it is amazing. The building of tolerance I could probably see it but i think if you stay couple days off you’re good to go again. I didn’t take any yesterday just to test and took today 1/2=100mg and it’s like night and day. As far as the increases in HR and BP I honestly don’t care given how good it makes me feel, totally worth it. Plus, I happened to be in a good spot with BP I’m usually low anyway 105-110/70-75 and an increase to say 120-125/80 I don’t think I would mind. However, I haven’t experienced and increase in BP nor HR that I can notice in last 10 days (since I started).
As far as sleep, boy o boy am I ever happy I found them both (modafinil and selegiline). I’ve been tortured for last 2-3 years with barely 5 hours sleep nights and in last 2 weeks (when I started both Selegiline and modafinil) I’ve averaged over 7 hours straight. I do take them first thing in the morning though. I don’t think I’d take modafinil after AM. As far selegiline I’ve taken it couple times around 2PM and it did not adversely affect my sleep even taking it that late. Modafinil though it feels different and I’m sure it would interfere with sleep if taken in the afternoon.
fyi- I’m loading up on it nicely. Just placed an order of 600 200mgs today in addition to about 800 I already have, I think it is an absolute must have for everyone.
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Idk when it turns into a waking dream or you go in a loop, it wrecks the therapeutic effect
I don’t disendorse psychedelics, but too many people advising me to do psychedelics did contribute to me getting into “weird situations” under them and my brain is more SEBUS-prone than most
The psychedelic with the lowest downside risk is DMT, esp b/c it lasts so quickly ( it’s also so intense you don’t end up doing dumb things outside or post to social media while on it). Plus you can legally do it in Colorado
I once helped host a DMT party and it cured one person’s trauma
Saffron does work to reduce depression as my friend started it and there really was improvement in about four weeks.
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Do you mean buying them from India?
I think it does a little too. The evidence is there IMO. Been taking 30mg with breakfast and another 30mg before bed (helps with sleep too).
yes. twenty characters