Yes, the PDF posted, all images relate to the WHP sample.
From the mass spec lab:
“The top panel shows an overview of what is ionizing in negative mode, the middle shows the overview of ionization in positive mode, and the bottom panel indicates the presence of the ion corresponding to Rapamycin. I am currently awaiting the results from the un-targeted search for potential contaminants, however, it does look as though there will be some potential degradation products from the Rapamycin in this sample"
Ok, so rapa is unstable under strong ionizing conditions; not surprising given the molecular complexity.
It would be best to compare the Aldrich sample to the same analyses to confirm that the (+) and (–) traces do not represent contaminants with unknown metabolic effects.
Broadly speaking, rapamycin has poor bioavailability when taken orally and only a small percentage of the drug is absorbed in the best of situations. Powder seems to be the least bioavailable, and all the drug companies that manufacture the tablets seem to have incorporated some sort of coating or nanocrystal technology to increase the bioavailability.
There seem to be problems with the other approach of taking rapamycin which is via rapamycin powder in capsules (typically provided by compounding pharmacies) which seems to also have problems, from a limited number of reports.
Since you have taken both tabs and powder did you notice one to out perform the other? Did you just increase your dose since the powder doesnt have the benefit of an enteric coating like tablets have?
I have not taken powder or capsules - only Tablets (Zydus and Biocon). And I’ve not done any blood sirolimus tests, so I don’t know how the doses of these two different tablets translate into blood levels.
I’ve purchased from his same supplier (some powder) - its about $60/gram. The product seems fine… I use it for toothpaste and skin cream. Mac used it for injection (and he’s still alive and kicking). I wouldn’t use it to consume orally just because I’m concerned about possible contaminants, but everyone has their own risk/reward profile.
You mix it in with a good skin cream (e.g. Cerave, Cetaphil, Aquaphor, etc.) then spread it on your face, or part of your body you want to help your skin.
I thought if you use it for injection the contaminants are more harmful than ingested orally (meaning bioavailability of anything taken orally will decrease in varying degrees)?
I would expect what you say to be true… obviously I’m more concerned about contaminants that Mac was. But to be honest my real concern is the contaminants over a longer period of time (think many years). The main issue are nitrosamines - these are cancer causing contaminants that can be found with some regularity in the drugs we buy unless screened for. They specifically look for these types of nitrosamines:
Nitrosamines
NDMA: not detected
NDEA: not detected
DMF: not detected
NEIPA: not detected
NDIPA: not detected
When I search this site http://www.hhdpharm.cn/en-us/ for either sirolimus or rapamycin I don’t get any hits? Do they no longer sell rapamycin powder or am I missing something?