“Eventually” is a vague term. Mine did not disappear after 13 years on Rapamycin. Should I wait for 13 more years maybe?
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There is something to it. I had a terrible lab test as I was slowly increasing dosage and my Doc threw a fit and put me on a statin for awhile. I didn’t get along with it very well and quit on my own and went with Niacin and no stink Garlic extract. Next time around my lipids were fine and he couldn’t believe it. I couldn’t either to tell you the truth. I think they came back down on their own. I also cut back on the Rapa some, but my feeling is that the lipids pretty much resolved themselves.
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Why could you "not believe it "?
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With Rapamycin one year ago, I had an LDL-C uptick as high as 179
Without changing anything it dropped 30 points in 3 months.
Now it has dropped again and is at 120 . My Coronary Calcium score is zero. Heart under age of 35 years. So a spike is not a big deal. Definitely not taking a statin. LOL
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What did you do to bring it to 141 from 179? I would love to stop taking statin at one point.
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But you’ve also reduced your dose from 6 to 2mg/week recently?
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I did nothing at all – no changes in diet, exercise or routine. At the time I was on weekly 6mg rapamycin with one Red Grapefurit juice. As you can see all my numbers dropped. I think my body finally got use to the rapamycin in my system - or it ran out of adipose tissue to convert. so less LDL-C in my blood?
Starting in December I changed to just 2mg rapamycin with one Red Grapefruit Juice.
I think the higher dose of 6mg with GFJ was not good. I had edema in my legs and a puffy face.
Been on the 2mg rapamycin with GFJ for 4 months. All good. Will retake my blood tests in a few weeks and see where my LDL-C is at.
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Wondering why it doesn’t work in me the same way. I have to take a statin.
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genetic predisposition?
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Possibly that’s it. Genetics I can have high LDL-C and no calcium or plaque.
My family is already long-lived with no heart disease or dementia.
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@LaraPo You raise a good point!
As someone who has taken Rapamycin for a long time, could you share which side effects or benefits have you found to be transitory that may have existed at the beginning but gradually faded over time?
Sorry if you have addressed this somewhere else.
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@Bicep Everyone has their own individual biology. I have found that with Rapamycin, it’s almost a ‘Wheel of Fortune’ spin to see what happens to you. Do you get canker sores? Fatigue? Too much energy? Lower inflammation? High lipids that may be transitory or not? Nothing at all?
It’s an amazing drug, and I would guess the results are based on how old/damaged (or good/young) our bodies are before taking Rapa.
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Exactly… I agree 100% with your statement.
As unique as each person’s aging journey… so is the unique recovery process.
My biggest gains… improved strength…maintaining muscle, loss of fat, improved memory, reversal of arthritis (inflammation) and repair of nerves causing dysphagia. Other benefits… but these are my biggest.
Started my fitness at age 58 years… did a lot of work pre-rapamycin…started rapamycin age 62 years, but had a great head start.
Perhaps why I think my health gains seem more extraordinary and fast.
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Do you also measure APoB?
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In the end these are all just surrogate markers which are associated with certain diseases but we have no idea how the diseases are caused. In animal models these markers move in the “wrong” direction too, yet rapamycin extends their health- and lifespan
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102 mg/dL?… So it looks high?
“Peter views the “ceiling” to be ~60 milligrams per deciliter”
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At the cusp of Boardline Line and Low High. My physician said it is reasonable.
He actually skips this test. I asked for it because those on here are very focused on it.
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I would recommend you read Chapter 7 of Attia’s new book and re-evaluate.
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Definitely more of an issue with those in 20’s to 30’s for intervention. Maybe not so much for 60’s up.
Link: Age and Cardiovascular Risk Attributable to Apolipoprotein B, Low‐Density Lipoprotein Cholesterol or Non‐High‐Density Lipoprotein Cholesterol - PMC
Depends on what the particles look like too - small, dart shape - not so good. Fluffy cloud -like that floats through blood - better. I am suppose to have large cloud shaped particles. Again, Coronary scan says all looks great - nothing to worry about.
Could do a hunt for soft plaque… and screenings… but not likely to be any different. Could do a CT Coronary angiogram Link: CT Coronary angiogram: a Simpler Way to Detect Heart Disease - Desert Medical Imaging.
No heart disease (or cancer) in my older siblings, parents, grandparents and relations.
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