was there a specific reason to add GJ and EVOO to your regimen? You are quite young, why did you want to increase the dose to that level? that fast?
I was really contemplating for more than a month what dose to choose, how to dose it optimally, how to increase bioavailability etc. but at the end realized that dosing is really very individual and should not make you feel worse and should not produce unwanted side effects. If they are present you are taking too much is my guide atm. One observation that that I made and metrics confirm is that I sleep much better since rapamycin. Even if I sleep less than usual I feel well rested and my deep sleep score on apple watch increased gradually from around 30 minutes of deep sleep (over the last years) to 57 minutes since I am taking rapamycin. I also read many experiences here on this forum that some changes are gradual, that side effect are less pronounced or resolved with timeā¦ I am taking rapamycin for a month so below observations might change in time.
I also noticed that my RHR goes up on the day I take rapamycin and stays elevated for a day or two. My average since started rapamycin actually dropped (my average was 60, since starting rapamycin it is 56).
I noticed changes in HRV too but in opposite direction. My HRV goes up on the day I take rapamycin and stays up for few days and is dose dependent, the more I take the more HRV increases (my average is 44, but since taking rapamycin it increased to 57).
I also notice this anxious feeling, it is similar to having to much caffeine in my case, but if it lasted for two/three days with my first dose (1mg) it is now resolved in hours after taking rapamycin (4mg).
Usually I donāt work out on the day I take rapamycin (started that first time I took it I was to jittery/anxious to do anything, so I skipped, I skipped also on subsequent dosing days), but I noticed that it is a harder for me to do resistance training, especially eccentric and isometric muscle contractions (working with resistance and holding positions) but not in the way that it worries me, just an observation I made. Not that I canāt do it, just that it feels harder, that I need to mobilize more power and will somehowā¦ Last Friday I also was training on my bike and I described it here in a different post that I had to rest, sit down and that I think I passed out for few seconds. I thought it is acarbose but it might be rapamycin as well (it is know that rapamycin can induce insulin sensitivity, but may also induce insulin resistance or glucose intolerance without insulin resistanceā¦) and will keep an eye on that.
I havenāt yet tested lipids since on rapamycin, but I have my pre rapamycin profile (day before my first dose) and it will be easy to compare if any changes happened as I did not change my diet or daily routine much and will take a lipid panel in two months again.
Iāve really been struggling with acne in recent months despite dropping my dose to 5mg/wk. Iām getting two or three puss filled spots per week. Perhaps doesnāt sound like a lot but theyāre barely healing before my next dose.
We do hear from users here that they suddenly start getting acne when they start using rapamycin. So there does seem to be a reasonably likelihood that the rapamycin, in some people, is triggering the acne (given that they had not had acne since they were teens).
The evaluation as to whether this means the ādose is too highā is a separate issue, and will vary depending upon the personās tolerance of the acne, and the level of acne. Certainly, a lower dose is likely to lower the incidence and severity of the acne.
Of course, there are a lot of animal study data that suggests that a higher dose is likely to result in a greater lifespan increase, so it seems to be a balancing act.
She refuses all supplementsā¦ rapamycin included. So as she gets olderā¦ weaker, with back and joint painā¦ weight gainā¦ and has me lifting and carrying things she once handled, she gets more pissed off at my boyish antics, carefree attitudeā¦ and excellent health.
So maybe I am a spotty teen again. My waist size is back to thatā¦ from 34 inchesā¦ 4 years ago to my youthful 30 inches once more. Waist size is a predictor of longevityā¦ among other things.
Also, I have less tolerance of old people 60ās upā¦ not considering myself at 65 in their category. Lol.
Getting acne is typical for transplant patients on rapamycin. It happens when immune system gets overly suppressed. I did get them before, when my trough measured higher than 5 (while taking 1mg/day without breaks), until I learned that it could be regulated with dose. I havenāt had a single pimple for years now after I changed the dose and time in between. Imo having pimples is a negative side effect which shows that immune system is malfunctioning. I try to avoid such situations.
Iām in my mid 40s and I feel that way about most people in my age group as well. Itās like everyone just gives up and decides to be old. And itās not just the physical part, itās also like they decide to start thinking like old people, too.
āChange is bad,ā refusing to try new technology, refusing to change their minds, only associating with people who think like they do, etc
I doubt Iāll be hanging out with many people my age in twenty years.
I would love to hang out with younger people because they have that optimistic naivete. But then I donāt want to be that creepy old guy. Damn. I agree that many people my age have just accepted āagingā and do not wish to rage against the machine.
I think it may be that the cost of supplements are prohibitive to most. If I look at how much I spend on my stack in one bill, it is eye-popping. Most cannot afford this.
Also, everyone has been inundated with exercise and healthy diet advice and so few people choose to follow the advice everyone agrees on because it takes too much effort. At least for me, the diet seems super easy and I now love my fruit and veggies with a little bit of meat. My problem is making time for the gym. Thatāll come in retirement. I am forced to retire at 60. Great time to start hitting the gym.
You all are great. We may be older chronologically, but weāre young at heart.
I read some studies and articles that dyslipidemia is transientā¦ why stopping immediately? Why not sticking with 4mg for a while and retest? Just asking what is the rationale, dyslipidemia for a couple of months wouldnāt mater that much if there is the possibility that it would resolve on its ownā¦
This benevolent dyslipidemia is caused by lipolysis and inhibition of lipoproteins uptake by the tissues (see Figure 2 in [94]). Dyslipidemia is reversible by itself [64].
Hyperlipidemia (or dyslipidemia) is a biomarker of the treatment with high doses of rapamycin and evirolimus.9 Rapalog-induced dyslipidemia is a benevolent sign of therapeutic effects. In fact, rapamycin prevents atherosclerosis.18, 19, 20
Hyperlipidemia is rapidly reversible.21 Eventually, hyperlipidemia disappears despite chronic use of rapamycin.22
Thank you for this as I was unaware. I love how this forum shares more than just opinions. I am curious if anyone here experienced an increase followed by a decrease while continuing to take rapa
I am in the UK and I take Rapamycin quite infrequently, but do a lot of other things. I have a blood test done almost every week. The threshold for concern about LDL-C in the UK is 3 mmol/L.
These are my results (one figure from 2021, then lots from 2022 and 2023).
What I notice is that
a) The lab I use seems to have an effect of about 0.5 mmol/L (as in some are consistently higher)
b) Delay in testing the sample reduces LDL-C
c) I think, however, my LDL-C has gone down even taking those things into account.
d) The results vary a lot from week to week. However, I vary what I do quite a bit although my diet is relatively consistent (save varying alcohol intakes)
I must admit, however, that seeing the variation would make me unwilling to rely on a single test on an infrequent basis.
