Should every drug go through mouse lifespan studies?

“Imagine that every time you were doing IND-enabling studies, you could also run a lifespan study in mice,” said the paper’s lead author, Insilico CEO Alex Zhavaronkov. “Every pharma program hits the 12-month IND-enabling window. Why not use that same year to run a parallel mouse lifespan study?”

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The only problem is cost.

However, I love the idea.

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Wouldn’t be that expensive compared to what companies spend. It would also be very good data.

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Having for decades observed how frequently studies on mice fail to generalize to humans, I’m on the other side of this issue. ITP, for example, is a worthwhile but overinterpreted initiative.

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1) What

image
https://x.com/alexkesin/status/1938658389934137587#m

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Ok so it’s basically happening. Even better. Slight alterations to these types of tests can make them suitable for lifespan analysis.