I will concur that when I sleep on my left side…my stomach is calm, however, when I sleep on the right side. I belch big and deep easily. Literally as soon as I flip…belch.
The difference is pretty dramatic.
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Could it be that it is because your liver and gallbladder is on your right side?
Lower esophageal sphincter is pressured ( by acid )when sleeping on the right side and acid tends to go “up” if you have low acid and lower esophageal sphincter is not fully closed.
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I have mild heart failure and I can’t sleep on my left side (I literally choke).
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Does anyone have a clue on whether carnosine supplementation jacks down serum taurine? And whether it can offset a low beta alanine level?
As mentioned by Curious, beta-alanine competes with taurine, sharing the same transporter. And vice-versa. My beta-alanine, already low before, suffered when I started taurine supplementation.
It is carnosine, not its amino-acid precursor beta-alanine, that directly provides possible large benefits. Carnosine has a different transporter so no competition with taurine. But how much carnosine from supplementation is absorbed directly vs broken down to its amino-acids - thus competing with taurine - before getting reconverted to carnisine? Hard to find data on.
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A starting point.
“Carnosine and taurine treatments diminished brain oxidative stress and apoptosis in D-galactose aging model”
“L-Carnosine and Taurine Supplementation Attenuates the Intensity of Diabetes in Alloxan-Induced Diabetic Male Albino Rats”
The link below is a seller/supplier of carnosine, has some good information.
I do no have any interest in carnosn.
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The answer to my question whether carnosine supplementation is absorbed or broken down into its amino acids is indicated in the following LEF statement on carnosine, linked by Joseph:
“Carnosine** is an amino acid compound found primarily in red meat. A typical red meat meal may provide 250 mg of carnosine, but this is quickly degraded in the body by the carnosinase enzyme. What this means is that even if a person relied on red meat for their carnosine, it would not last long enough in the body to provide sustained protective effects. Supplementation with 1,000 mg a day of carnosine overwhelms the carnosinase enzyme, thus enabling one to maintain consistent blood levels of this critical nutrient”.
I will try to find the evidence for the last sentence in a scientific article, but in the meantime. I will presume it is correct. That it is, is indicated by various research articles showing beneficial effects of high-dose carnosine supplementation, albeit mainly in lab and animal studies. It seems that if the dose is high enough, carnosine will be absorbed by the cells without break-down.
I will continue with taurine supplementation, search for the best carnosine supp, and not worry about my low beta-analine number.
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Take a minimum of 1,000mg a day of carnosine if you want a consistent blood level.
And review;
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Joseph: Whilst carnosine is most impressive in lab studies, sadly this does not seem to be the case for humans, at least for the brain. The abstracts for a bunch of clinical studies relating to neurology appear most promising. But a dive into the tables on the changes in the individuals after carnosine supplementation show weak or inconclusive data in each case. Maybe it´s a fault of the studies not being long enough to create the sought improvements.
Anyway, I will go for carnosine. My serum beta-alanine is close to the lowest point of the reference range. Which should mean that carnosine is low as well and bumping it up can only be a good thing.
Maybe the overwhelming of the carnosinase enzyme that I brought up isn´t crucial. If not directly absorbed, carnosine is quickly cleaved by carnosinase inte beta-alanine and histadine, and then formed back into carnosine through carnosine synthetase. If the latter is effective a high dose is not necessary for absorption. I will start with a 500 g dose.
Shamelessly plagiarizing from a Blagosklonny paper.
“If you wait until you are ready, it is almost certainly too late.”
~Seth Godin
I am not the waiting type.
The same is said of “rapamycin” extending " human lifespan.
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