My comment;
Was this the possible reason/thinking of the company overseas that was selling 4mg capsules of rapamycin with the only filler/dilution material was taurine?
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Fortunately it’s pretty easy to get as much as they got in the study (1500 mg/day) from whole foods, especially sea food and when following a carnivore diet…
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Another paper on Taurine… A good itp candidate?
Taurine deficiency as a driver of aging
Aging is associated with physiological changes that range in scale from organelles to organ systems, but we are still working to understand the molecular basis for these changes. Studying various animals, Singh et al . found that the amount of the semi-essential amino acid taurine in circulation decreased with age (see the Perspective by McGaunn and Baur). Supplementation with taurine slowed key markers of aging such as increased DNA damage, telomerase deficiency, impaired mitochondrial function, and cellular senescence. Loss of taurine in humans was associated with aging-related diseases, and concentrations of taurine and its metabolites increased in response to exercise. Taurine supplementation improved life span in mice and health span in monkeys. —L. Bryan Ray
Taurine-fed mice of both sexes survived longer than the control mice. The median life span of taurine-treated mice increased by 10 to 12%, and life expectancy at 28 months increased by about 18 to 25%. A meaningful antiaging therapy should not only improve life span but also health span, the period of healthy living. We, therefore, investigated the health of taurine-fed middle-aged mice and found an improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, indicating an overall increase in health span.
Paper:
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Pretty amazing. Wonder what kind of dose it would take.
Here is the dosing in the paper:
Taurine supplementation increases the life span of mice
To determine whether the observed drop in taurine concentration contributes to aging, we orally administered control solution or taurine at 1000 mg per kg body weight (T1000), once daily at 10:00 am, to 14-month-old (middle-aged) C57Bl/6J WT female and male mice until the end of life. The dose and frequency of taurine administration was selected based on a pilot study, which showed that when given once daily to middle-aged WT mice, this regimen increased the peak blood taurine concentrations to baseline concentrations in young (4-week-old) mice (see materials and methods and fig. S1, A to D, for a description of these studies). Regardless of their sex, taurine-fed mice survived longer than control mice (Fig. 1, D and E). The median life-span increase was 10 to 12%, and life expectancy at 28 months increased by 18 to 25% (Fig. 1, D and E). Median life-span estimates for control female and male mice were consistent in two independent cohorts (females: 871 to 885 days; males: 785 to 815 days). In these experiments, both control and taurine-fed mice had ad libitum access to the same chow (Teklad Irradiated 18% protein and 6% fat diet-2918). Thus, the improved survival of taurine-fed mice was not a consequence of low survival of control animals or differences in diet. Collectively, these results indicate that taurine deficiency is a driver of aging in mice because its reversal increases life span.
Full Paper: https://www.science.org/doi/10.1126/science.abn9257
One person’s estimate and a comment by Pankaj Kapahi who’s postdoc at the Buck Institute was one of the authors…
If I did the arithmetic right, the human equivalent dose of taurine used in the study is about 2.8-5.7g for a 70kg human:
Study used 500-1000mg/kg in mice. Divide by 12.3 to allometrically scale to get 40.7-81.3mg/kg. Multiply by 70kg to get 2.8-5.7g.
This 2.8-5.7g dose range is in line with safe dose ranges used in previous human studies. And in the range of what people actually take (e.g. athletes) when they supplement taurine (maybe on the high end).
Pankaj Kapahi
I have been taking about 2-3 g/ day since I learnt about it from him
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N -1 George Eby wrote about his own experience treating his afib with taurine.
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The results are very impressive. Reminds me some of gly/ nac.
I think that the equivalent dose in humans would be about 5 grams per day.
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