Second week at 12mg of reta!
Appetite supression is really mild I can still eat 2000kcal (on a 3000kcal maintenance).
HR is almost the same. Skin sensations are really down but it weirdly depends on the day.
Here a 1 month difference. A few kilos of fat to lose and I’ll be good. I don’t plan to lower the dose, I want to downsize a bit (I was up to 92kg for 1m72, cardio was getting harder and moving was difficult for some movements like putting my socks…
How is the sleep apnea going?
The CPAP is a game changer, I no longer fall asleep everywhere and I feel rested when I wake up.
I average 9h of sleep.
Last time the technician was here the count of sleep apnea has been divided by 65, I was doing 2 events an hour instead of 128.
BP and HR and down.
Nice. Better to have it under control but hopefully you can get rid of the sleep apnea entirely and not need the machine. Machine drove me crazy.
My whole X feed is discussing the Retatrutide phase 3 results. Seems to be what everyone is talking about right now.
I wonder if the other metabolic/anti inflammation etc health affects are just as dose dependent… thats why I was aiming to get up there in dosage
Apparently there are tests to measure glp-1 in plasma which I may need. Aside from being an ectomorph, I think a possible reason I’m responding so well in terms of weight loss/side effects to a lower dosage is because of the other supplements I’m taking that either are additive or synergistic to the process. Not only the copies glycine I take, but apparently Telmisartan (and I take 80 mg) acts synergistic with it and who knows what else in a persons lengthy stack could influence the process
I suspect not, if someone responds very well to the drug. But metabolic benefits are things you can easily measure with blood tests to validate your hypothesis in your specific case.
Both increased RHR but not in a concerning way:
Tirz at 14mg/week - RHR up 4-5 from base
Reta at 12mg/week - RHR up 6-8 from base.
Base: 61 - Tirz: 65 - Reta: 69
I believe these tests for specific blood serum GLP or similar are proprietary to EL and Novo.
But the end goals are different and include biomarkers you can test:
Metabolic Health & Inflammation Panel
| Marker Category | Common Name | Exact Labcorp Test Name | Labcorp Test Code |
|---|---|---|---|
| Blood Sugar & Insulin | Fasting Glucose | Glucose, Serum (or as part of a Comprehensive Metabolic Panel) | 001032 (or 001400) |
| Blood Sugar & Insulin | Hemoglobin A1c | Hemoglobin (Hb) A1c | 001453 |
| Blood Sugar & Insulin | Fasting Insulin | Insulin | 004333 |
| Lipids & Cardiovascular | Standard Lipids | Lipid Panel | 303756 |
| Lipids & Cardiovascular | Apolipoprotein B | Lipid Panel with Apolipoprotein B (ApoB) | 123544 |
| Inflammation | hs-CRP | C-Reactive Protein (CRP), High Sensitivity (Cardiac Risk Assessment) | 120766 |
| Inflammation | Homocysteine | Homocyst(e)ine | 706994 |
And if bothering to test those, consider also testing common markers with valuable info:
Core Companion Panel Additions
| Marker Category | Common Name | Exact Labcorp Test Name | Labcorp Test Code |
|---|---|---|---|
| Foundational Health | CBC with Diff | CBC With Differential/Platelet | 005009 |
| Foundational Health | CMP | Comprehensive Metabolic Panel (14) | 001400 |
| Metabolic Control | TSH (Thyroid) | Thyroid-stimulating Hormone (TSH) | 004259 |
| Inflammation / Storage | Ferritin | Ferritin | 004598 |
| Metabolic / Gout Risk | Uric Acid | Uric Acid | 001057 |
| Hormone / Immune | Vitamin D | Vitamin D, 25-Hydroxy | 081950 |
New triple agonist GLP1 hitting the same things but likely different ratio of what it is hitting. I suspect more glucagon.
Novo Nordisk’s CEO believes its triple agonist UBT251 could ultimately outperform Eli Lilly’s retatrutide, though the evidence is still early. Retatrutide is already in late-stage trials and has shown about 28–30% weight loss over 1.5–2 years, which analysts describe as “unprecedented,” but with some tolerability concerns. UBT251 is still in phase II with about 20% weight loss at 24 weeks in early data. At present, retatrutide has much stronger clinical backing, while UBT251 is a promising but unproven challenger.
Have someone here tried 15mg once weekly for more glucagon activation? First week for me at that dose, I feel great, no side effects.
Max dose is 12mg. You get glucagon effects at every dose; the magnitude is dose-dependent
I kwow, that’s the point for me taking 15mg.
A few brave(ish) folks have reported using more than 12mg, some experience more sides but I don’t remember anyone reporting significantly more weight loss nor other lab results showing improvements.
Reta is some remarkably powerful medicine, 15mg Tirz is likely equal to 4-8mg Reta (corrected). More than 12mg not recommended though I’m sure folks are curious about results (scale and lab) if you try.
This all sounds crazy to me. I was on 2.5 / mg of Tirzapetide since around December - January and lost over 15 lb (rather often I’d skip a week though). In the beginning I had a period of a few weeks of higher RHR and tanked HRV that slowly both rebounded. Now that I switched to 2 mg Reta I was hoping my body would skip that phase from it being familiar since tirzapetide. Nope! I feel completely hung over the day after injection. Makes me wish I hadn’t switched horses as it took so long for my body to get used to tirzapetide. Now I have to suck it up all over again. But with such sharp sympathetic activation at 2 mg I get dizzy imagining jabbing myself with 12 or 15 mg. Would probably send me to the ER. Then again I’m pretty lean (120lb, 5 foot 3) and very insulin sensitive to begin with. I wonder if the side effects are more pronounced with people who “need” it the least.
You have it upside down bud. Reta 7-8mg is about equal to Tirze 10-12mg.
I would say 4mg retatrutide is closer to 10-15mg tirzepatide, judging by the very recent data. Powerful stuff.
