Therapeutic dose starts at 4mg. 8mg is one of the doses that had major weight loss. 12mg was better, but not by much. Some people think glucagon only kicks in at higher doses, but pre clinical data shows that you get glucagon activation at low doses.
Over time, you’ll find that your appetite returns, but that you keep losing weight.
Does the appetite always return under all doses?
Does the body get used to all doses?
One of the reasons I titrated up to 6, in addition to wanting to get to the 8-12 range that saw the most dramatic results in weight change and I’m guessing metabolic/anti inflmmatory change (aren’t a lot of the changes dose dependent?), is that I felt my appetite was back after a month of 4mg… Now after a month of 6mg still waiting for some equilibrium in terms of side effects…
If it continues I will just retreat to 4mg
Appetite returns, yes. If you browse GLP1 related forums, you’ll see posts about people panicking/complaining about lack of appetite surpression after being on a dose for awhile (mostly tirzepatide, semaglutide but this applies to all GLP1a) . They’re often worried about gaining the weight back since they’re eating more, but what ends up happening is that although they may not be losing more weight, they’re maintaining their weight loss.
I would increase the dose only on a weight loss plateau (4 weeks of no weight loss), not on loss of appetite suppression.
Your body gets used to a dose over time, if you’re talking about side effects . I’ve been on the same high dose for 4 months, and I’ve had 0 side effects on that dose, while slowly losing more weight. My appetite has been pretty normal during that period.
You can always monitor some changes via a metabolic panel. I saw my markers improve early when I was on only 4mg: decrease on A1c, Triglycerides, and better egfr.
I haven’t been losing weight slowly… I’ve been on the med for a little over 3 months and went from ~198 to ~162…
This might be part of the issue…
I increased the dose even while running through the weight, having dizziness etc
I may need to take a step back and think its working too well for me… and need to be more selective with titrating up…
I’m seeing the trials and they are talking about 12mg for mass weight loss when it was heading that way for me on low dosage…
I suspect that I take a lot of glycine is at issue… it has glp affects which can be additive I’m thinking and folks often take glycine with these meds
Thats good, having this conversation made it obvious to me what my next move should be, lol.
I just though I saw some dose dependent reports that made me want to shoot for the stars.
3 years ago, the obesity drug market was basically Ozempic. Today, it’s 9 drugs deep in late-stage. Here’s what each one actually adds:
Foundayo: latest oral GLP-1. approved April 1, 2026. Injections become optional.
Retatrutide: 24% weight loss at 48 weeks (Phase 2). Triple agonist.
CagriSema: less nausea than semaglutide. NDA filed December 2025.
Survodutide: GLP-1 + glucagon. Cuts liver fat alongside weight.
Amycretin: oral weekly. GLP-1 + amylin. Phase 2.
Petrelintide: amylin only. Phase 2 posted March 2026.
Mazdutide: China approved 2026. US Phase 3 ongoing.
Pemvidutide: obesity + MASH dual indication.
Monlunabant: CB1 inverse agonist. Phase 2.
The next pharma cycle may not be Novo vs Lilly. It’s shaping up as mechanism vs mechanism.
Source: https://x.com/agingroy/status/2045551011612500182?s=20
Hi
For the people on retatrutide here, do you have the skin burning sensation/itching? It’s so annoying when you try to sleep. It’s really a weird sensation. I’m week 1 on 8mg a week.
It’s not a histamine problem I’m already take 5mg of desloratadine daily.
Thanks
Reta ‘can cause skin-related discomfort known as allodynia or dysesthesia, which is described as heightened sensitivity, burning, tingling, or pain from light touch. Roughly 7–21% of users in high-dose studies reported this, often described as a sunburn-like sensation, which is typically temporary and dose-dependent.’
I’ve never had it but some suggest a zinc supplement helps. I suspect the zinc doesn’t do much and it’s just people having the effect diminish because some time has gone by as it’s often temporary.
I have dealt with this one for several years and have a cost effective fix…
Have a snack… appetite goes away in 10 - 15 minutes due to the satiety effect from GLP1’s
Or I tell them to grow up and use some self control LoL!
satiety effect from glp1 (1).pdf (304.5 KB)
Just don’t take too much of that Reta (or other GLP)…
And, the full case-study paper write-up on the event 
40mg in 2 days. Not smart. There will be more of those overdoses, some people get very confused about reconstitution math.
I think diarrhea or gastro symptoms are a sign that you’re on too much.
Aside from still not being able to have an appetite after 6-7 weeks of 6 mg, I was getting IBS-D symptoms that I thought were a bacterial bug, in addition to light headed, near hypotension blood pressure
I wanted to get up to the 8-12 range but that isn’t made for everyone. Maybe being naturally an ectomorph or the other things in my stack, dietary and prescription that can enhance the glp process as well
Why were you pushing such high doses of reta if you’re an ectomorph?
All GLP1s can cause it. I’ve experienced it with doses of tirzepatide higher than 10mg. It is transient and not that annoying. Sort of feels like sunburn.
Thanks for the video! I asked my PCP a second time and she said yes. So I can get the prescription version of tirzepatide in vials and self inject. I start this week.
Weird theory, but I wonder if what you’re feeling is accelerated burning of junk and fat cells in your skin.
To my knowledge it’s pretty encompassing in its health effects besides the weight issue, in terms of metabolic improvements, protection of organs, against cognitive decline, cancer etc.
I should also say, I wasn’t blessed with the best metabolism as a ecotomorph. While it’s true I’m a 6’3 160 stick now, I was the definition of skinny fat and had the frame of a lot of visceral fat at 6’3/200 while starting (admittedly, not the best diet/lifestyle). Despite weight lifting program, never could gain much muscle
For any of you that have used both Tirzepatide and Retatrutide, did you notice a different in resting heart rate between the two?
I think this has been beaten to death previously but for me not much of difference, went up about 10-15 and stayed there no matter which I did. I stopped them cold (all peps) including GLp1’s and HR is trending down again, albeit slowly, down about 5-6 in last 6-7 months.
Having said that I’ve read people saying that they had more increases from reta than tirze, and some people claiming very little increases from either (i.e. 3-4 points). As it has been noted GLP1’s seem to have big differences from person to person (the weight loss, and side effects), more so than with other meds.
