I know more than a few people taking either Tirz or Reta and none have reported any seriously concerning psychological issues. Most people do not experience psychological effects out side the “flatness” in how they feel about food and other things that drive impulsive behavior. I guess that could be classed as an anhedonia response but it doesn’t seem to bother any of the people I know. In fact most are quite happy not having uncorralled urges.
Personally I still have my urges
But I have seen a few issues that are atypical, one was insomnia. A rare side effect. Was resolved with timing related to food and alcohol consumption, nothing to eat after 6:00pm and no alcohol after 6:00pm. That resolved this side effect in a week. 2 months later the individual was able to eat and drink as was their previous normal lifestyle without experiencing insomnia.
It seems most side effects from GLP1 resolve over time but a few do not.
Bowel movements are one that seems to vary for many, often switching back and forth from constipation to diarrhea. This side effect is probably related to an inconsistent diet.
Some experience transient nausea every time they increase the dose for the few days and later in the week it goes away. This sometimes happens for the first 2 week with a dose increase and then resolves completely, until the next dose increase.
And then there is the vast majority who sail through with minimal sides that all go away and never return.
I think coaching from an experienced person is one of the keys to successful use of GLP1’s and I don’t mean following the pharma guide lines on dosing. Low and slow, like good BBQ, is the best way to handle this for non-T2D healthy adults. Patience and consistency, not changing dose willy nilly and letting the scale be your best source of data.
Association of Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review 2026: “Our findings indicate liraglutide (reported odds ratio [ROR] = 3.26, 95% CI = 2.53, 4.22) and semaglutide (ROR = 1.73; 95% CI = 0.30, 0.80) are significantly associated with a greater odds ratio of reported suicidal ideation. Similarly, tirzepatide was associated with greater odds of reported suicidal ideation; however, this was nonsignificant (ROR = 1.49; 95% CI = −0.41, 1.21). Similarly, semaglutide (ROR = 8.81; 95% CI = 3.69, 21.04) and liraglutide (ROR = 3.74; 95% CI = 1.23, 11.38) are also associated with a greater odds ratio of reported suicidal depression. No significant association between other GLP-1 RAs and suicidality was observed.”
The effect of glucagon-like Peptide-1 receptor agonists on measures of suicidality: A systematic review 2025: “suicide ideation (SI) […] Pharmacovigilance studies indicate that semaglutide and liraglutide are associated with disproportionate reporting of SI. Results from cohort studies indicate that GLP-1 RAs are not consistently associated with an increase in any aspect of suicidality; instead, some agents are associated with decreased SI and SA.”
So the suicide ideation risk exists but might be limited to semaglutide (and potentially tirzepatide). Hopefully retatrutide is better.
How are you taking such a low dose? I had assumed that Reta like Tirzepatide would be in a dose controlled injector and dose would not be adjustable. I have been looking for a way to try a micro dose of tirzepatide because some doctors have reported success using it to reduce long covid food sensitivities. But they only had easy access to microdoses when there was a tirzeptide shortage and compounders were then allowed to fill prescriptions. Reta when it becomes generally available might be another option for me to try if I could microdose.
Vials of all the GLPs are available online from both Chinese and domestic sources. Chinese vendors are cheaper by an order of magnitude. You’ll need to do a lot of reading, a lot of independent research, to get yourself safely up to speed. This site is a good place to start, but there are several others that are equally informative.
Is anyone pairing imeglimin with retatrutide? Curious to hear about experiences.
(pls excuse the duplicate posting in the imeglimin thread)
Claude seems to think these would be synergestic, and in my opinion, Reta + SGLT-2 + imeglimin is probably a much more beneficial stack than whatever crazy & expensive things other biohackers are carrying out (e.g. reta + tesamorelin — which is probably the safest among the other crazy stuff going on in that space).
Excerpt of chat with Claude:
" Here’s the reasoning for why imeglimin (the “glimin” class oral antidiabetic, approved in Japan) could complement retatrutide (Lilly’s GIP/GLP-1/glucagon triple agonist):
Complementary mechanisms
Retatrutide acts at the receptor level — it agonizes GLP-1R, GIPR, and GcgR to drive weight loss, improve incretin signaling, and increase energy expenditure. Imeglimin works at the cellular/mitochondrial level, amplifying glucose-stimulated insulin secretion and preserving β-cell mass, while also enhancing insulin action in the liver and skeletal muscle PubMed Central. These are largely non-overlapping targets.
This is arguably the most compelling rationale. Retatrutide’s glucagon receptor agonism is intended to increase energy expenditure and lipolysis, but glucagon also stimulates hepatic gluconeogenesis — a potential glycemic liability. Imeglimin directly targets excess hepatic gluconeogenesis as one of its three core mechanisms PubMed Central, which could offset this side effect of glucagon agonism.
β-cell protection
Retatrutide drives sustained metabolic stress (weight loss, altered fuel partitioning). Imeglimin’s mitochondrial mechanism — rebalancing respiratory chain activity and reducing reactive oxygen species — preserves β-cell mass and function PubMed Central, which could support long-term durability of glycemic benefit.
Additive glucose-dependent insulin secretion with low hypoglycemia risk
Like GLP-1 receptor agonists, imeglimin enhances insulin secretion in an exclusively glucose-dependent manner, but their mechanism of action at the cellular level diverges PubMed — imeglimin works through NAD⁺/ATP amplification rather than receptor signaling. So combining them adds two independent glucose-dependent insulin-secretion pathways without substantially increasing hypoglycemia risk.
Residual insulin resistance
Retatrutide’s primary benefit is weight-mediated metabolic improvement. But imeglimin targets multiple mechanisms — increasing insulin sensitivity, decreasing gluconeogenesis, increasing β-cell function, and improving mitochondrial function PubMed Central — potentially addressing insulin resistance that persists beyond what weight loss alone corrects."
Yes, contaminants could be a real problem but it seems to me that everybody must synthesize peptides in a similar if not identical way. And, peptides are macro-molecules so purifying them by dialysis or by exclusion columns would seem to be cheap, easy, and routine. All this to say that I wonder if contaminants are as big of a problem as people think?
It would be nice to see a study of random grey market peptides from various sources to determine what the contaminants are and how prevalent the problem. Peptide identity and degradation or partial synthesis products would seem to be a more likely variable.
Weight and Fat Reduction : retatrutide specifically reduced the mass of epididymal, inguinal, and interscapular brown adipose depots.
weight loss was driven by enhanced energy expenditure rather than chronic appetite suppression, as food intake did not significantly differ between the HFD and Retatrutide-treated groups during the intervention.
Multi-omic analysis of epididymal WAT (eWAT) revealed that Retatrutide transforms “sick” fat into a metabolically active organ through several coordinated processes:
– shifted the transcriptional landscape from lipid storage to lipid oxidation
– suppressed pro-fibrotic signaling pathways (TGF-β, focal adhesion) and reduced collagen-derived metabolites. It also attenuated broad-spectrum pro-inflammatory genes and pathways (NF-κB, Toll-like receptor signaling) while restoring anti-inflammatory immunoregulatory genes.
– promoted tissue repair by upregulating pro-homeostatic and angiogenic markers
– restored mitochondrial membrane integrity and peroxisomal activity, both of which are typically compromised in obesity.
I have NEVER heard someone getting sick from buying/using grey market peptide, NEVER. I have bought and used about 30 peptides (all useless btw) from probably 10 different gray/black market suppliers, and I have never gotten sick from using these peps. Having said that there was a case in LV where couple people were injected with supposedly some kind of peptide and ended up in the hospital, but who knows what they were injected with, plus that doesn’t count as gray since they were literally administered the injection while taking part in some sort of peptide convention or something similar. To each their own but I have little sympathy for those that show up at a hotel somewhere and let a stranger inject stuff into their bodies. So, I don’t think this counts as gray market stuff.
That’s interesting, as I’ve heard Reta doesn’t have to suppress appetitie, while it’s annihilating mine currently. Maybe that’s the signal that it’s too high a dose
The dosages for non diabetic/non obese longevity users might be different than the doses used for those who are sick - I’m learning
I pushed it to 6mg, probably stupidly, and after a month still can’t look at food when I was already losing strongly at 4mg and my blood pressure and glucose were already down
I had that 8mg in my mind as what some consider “therapeutic dose”
