I know more than a few people taking either Tirz or Reta and none have reported any seriously concerning psychological issues. Most people do not experience psychological effects out side the “flatness” in how they feel about food and other things that drive impulsive behavior. I guess that could be classed as an anhedonia response but it doesn’t seem to bother any of the people I know. In fact most are quite happy not having uncorralled urges.
Personally I still have my urges
But I have seen a few issues that are atypical, one was insomnia. A rare side effect. Was resolved with timing related to food and alcohol consumption, nothing to eat after 6:00pm and no alcohol after 6:00pm. That resolved this side effect resolved in a week. 2 months later the individual was able to eat and drink as was their previous normal lifestyle without experiencing insomnia.
It seems most side effects from GLP1 resolve over time but a few do not.
Bowel movements are one that seems to vary for many, often switching back and forth from constipation to diarrhea. This sided effect is probably related to an inconsistent diet.
Some experience transient nausea every time they increase the dose for the few days and later in the week it goes away. This sometimes happens for the first 2 week with a dose increase and then resolves completely, until the next dose increase.
And then there is the vast majority who sail through with minimal sides that all go away and never return.
I think coaching from an experienced person is one of the keys to successful use of GLP1’s and I don’t mean following the pharma guide lines on dosing. Low and slow, like good BBQ, is the best way to handle this for non-T2D healthy adults. Patience and consistency, not changing dose willy nilly and letting the scale be your best source of data.
Association of Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review 2026: “Our findings indicate liraglutide (reported odds ratio [ROR] = 3.26, 95% CI = 2.53, 4.22) and semaglutide (ROR = 1.73; 95% CI = 0.30, 0.80) are significantly associated with a greater odds ratio of reported suicidal ideation. Similarly, tirzepatide was associated with greater odds of reported suicidal ideation; however, this was nonsignificant (ROR = 1.49; 95% CI = −0.41, 1.21). Similarly, semaglutide (ROR = 8.81; 95% CI = 3.69, 21.04) and liraglutide (ROR = 3.74; 95% CI = 1.23, 11.38) are also associated with a greater odds ratio of reported suicidal depression. No significant association between other GLP-1 RAs and suicidality was observed.”
The effect of glucagon-like Peptide-1 receptor agonists on measures of suicidality: A systematic review 2025: “suicide ideation (SI) […] Pharmacovigilance studies indicate that semaglutide and liraglutide are associated with disproportionate reporting of SI. Results from cohort studies indicate that GLP-1 RAs are not consistently associated with an increase in any aspect of suicidality; instead, some agents are associated with decreased SI and SA.”
So the suicide ideation risk exists but might be limited to semaglutide (and potentially tirzepatide). Hopefully retatrutide is better.
How are you taking such a low dose? I had assumed that Reta like Tirzepatide would be in a dose controlled injector and dose would not be adjustable. I have been looking for a way to try a micro dose of tirzepatide because some doctors have reported success using it to reduce long covid food sensitivities. But they only had easy access to microdoses when there was a tirzeptide shortage and compounders were then allowed to fill prescriptions. Reta when it becomes generally available might be another option for me to try if I could microdose.
Vials of all the GLPs are available online from both Chinese and domestic sources. Chinese vendors are cheaper by an order of magnitude. You’ll need to do a lot of reading, a lot of independent research, to get yourself safely up to speed. This site is a good place to start, but there are several others that are equally informative.
