Flare up of HPV in numerous places on the bod(much more severe than just skin tags) , enlarged lymph nodes, depressed mood, anxiety. It did improve after 6 months but not disappeared completely.
I am a relatively young (36) healthy person and it made me feel worse not better
What dose did you use at the highest point?
What is new study showing best to take metformin in morning?
8mg once a week… built up slowly over 2 months and I persisted with it
Are you still taking rapamycin, or are you taking a break now? Will you take it again?
@Sfcomms & @nym Very interesting regarding the improved oral health. What dose regime are you currently on? Curious also what brand and manufacture of rapamycin you use if that can have any impact.
i’m on 5mg weekly now but started at 1mg for a couple of weeks, then 2mg for a couple of weeks, then 3, you get the idea. i take sirolimus pills. i noticed dental improvement by the time i got to 4mg so around 2 months. i don’t have periodontal disease but deep pockets and my gums bleed when i floss, which i do daily. it’s genetic. i noticed it and then my dentist confirmed. we are giving it a couple more months and will take for,al measurements and x-rays to compare.
my 1h levels were 4.5 and 2.2 at 48h (with 4mg). i would invest in testing twice to see where you are and make sure you are washing out (or have anything to start with). keep in mind that there seems to be gender difference in bioavailability levels. i’m female
cheers
I have noticed the last two times that I’ve taken Sirolimus (every other Saturday) the first week following I feel run down and achy, around 8 days later I feel very good and strong.
Last dose taken; 5mg with grapefruit juice 1 hr before.
Anyone else?
I think you should include something like brain fog. I just couldn’t remember my nouns. People’s names or the names of things I want to talk about. Really embarrassing and inconvenient and Rapa knocked it right out.
-I’d like to know the diet of users here, like low carb, keto, SAD, low fat, low glycemic / slow carb (me).
-age ranges
-taking Rapa on weight training days vs rest days.
I’m also wondering about any correlation of dosing levels to side effects and severity of side effects. Maybe in the next survey I split the respondents up into dosing tiers - e.g. 1 to 5mg/week, 5 to 10mg/week, 10 to 20mg/week, 20mg to 30mg… etc. - then ask about side effects for each group. We should see a dose/response relationship in the side effects.
Sounds like a good question - you seem to know something about these diets, can you draft a question I can use, and provide rough guidelines so people can self-identify with a specific group. If we just say “low carb”, people’s interpretations on what “low carb” means may really muddy the data.
6mg once per week, using Sirokem from Kalchela Medex - generic from India. Not sure of the quality, but it’s having some effect, judging from the improved oral health alone.
I would like to see the frequency and dosage results corelated. I’ve been doing 6mg/wk for a year. Just switched to 8mg/10d. Looking for any changes.
Somewhat like… me I did 6MG for one and a 1/2 years… then started 8MG to 10MG for 2 months and then started the 6MG with grapefruit juice to date… yesterday. Gives me 30ng /mL in my blood.
Me too! I feel great after a week off but I am fatigued for about 5 days.
There is a connection between rapamycin, “brain fog”, Covid, aging, cardiac fibrosis and something called the NLRP3 inflammasome.
Severe Covid or aging can overactivate NLRP3. Conversely, inhibition or knockout of NLRP3 can result in reduced cardiac fibrosis, an increase in autophagy and NAD+ levels.
So, if we look at things that block or inhibit NLRP3 we might find things that reduce the severity of Covid, counter aging and brain fog (closely allied to Chronic Fatigue Syndrome) and reduce cardiac fibrosis.
The list of NLRP3 inhibitors includes (but is not limited to):
Glucosamine
Metformin
Salvianolate
Triptolide
Beta-Hydroxybutyrate
Rapamycin
Hydrogen
This is an amazing explanation. I’ve been trying to read about it all morning. My dad had this problem as well. His brain was working just fine but he couldn’t find the words he wanted. We must have gotten the overactive NLRP3 gene.
I’m taking glucosamine daily and Rapa every 2 weeks. I’ve been putting off asking my doc about a low dose of Metformin. My sugars are so normal that he will drag his feet I think.
Keto works great for me but I eat enough of veg. and berries and they have so many carbs that I don’t spend any time in true optimal ketosis. Even when I was very strict I really couldn’t do it. I did just order Juvenescence to see how I like it. I used to use a lot of exogenous keto salts and thought they worked, but I don’t know how well. They helped me stay alert when keto on hard work days. So maybe the beta-hydroxybuterate from the Juvenescence will keep my brain working this fall.
This could help with heart disease too!
Thanks, Doc
I like this idea - but I’m unsure on how to implement this in a survey like this (given the software limitations… very simple polls (no branching, conditional questions, etc.). Any suggestions greatly appreciated.
Here is my updated idea list for questions/response options in a future rapamycin user poll / survey (perhaps in a month or so).
Please review and make suggestions for improvement or additions. All input appreciated:
How Long Have You Used Rapamycin?
Under 1 year
1 to 2 years
2 to 3 years
3 to 4 years
4 to 5 years
Over 5 years
How old were you when you started rapamycin?
20 to 24 years
25 to 29 years
30 to 34 years
35 to 39 years
40 to 44 years
45 to 49 years
50 to 54 years
55 to 59 years
60 to 69 years
70 to 79 years
80+ Years
What Benefits do you think Rapamycin use has given you?
More Energy / Reduced Fatigue
Better Sleep
Reduced “brain fog”, Improved Cognition
Improved Skin look/texture/tone
Feel Younger
Improved Weight Management, Weight Loss or Fat Loss
Improved Blood Test Results
Better /More Frequent Erections
Fewer Aches and Pains
Better Mood / Emotional Resilience
Improved /More consistent Menstrual Cycle
Reversed Perimenopause/Menopause
Improved Oral Health
No Cold / Flu / Covid while other family members got it
Lower biological age measurement
improving hearing, less tinnitus
Lower Blood Pressure
Reduced Phlegm Buildup in Throat at Night
Elimination of Toenail Fungus
Reduced Eye Discharge (sleep) During Night
Reduced Arthritis / Osteoarthritis
Less Need to Urinate at Night
Improved IBS symptoms
Reduced Joint Pain
Improved Athletic Endurance
Improved Resilience to Sleep Deprivation
Reduced Swelling
No Perceived Benefits
What Side Effects do you think Rapamycin has caused for you?
Mouth or tongue Sore
Skin Rash / Acne
Blood Cholesterol Increase
Blood Glucose Increase
Skin Tags (small skin growths)
Increased Bacterial Infections
Runny Nose
Insomnia
Hot Flashes / Night Sweats
Cough
Increased Aches and/or Pains
Headache
Fatigue
Diarrhea
Dry Mouth
Oral Pain
Itchy Skin (pruritus) or Tingling or prickling of skin
Metallic taste in mouth
Pink eye (conjunctivitis) or Bloodshot eye
Neutropenia (abnormally low count of a type of white blood cell)
Dispepsia / Indigestion
Urinary Tract Infection
Shingles Breakout
No Noticeable Side Effects
How Often Have You Experienced Rapamycin-related Side Effects?
Once
A few times
Many times
Every Dose
How bothersome / troublesome / painful / upsetting are the Rapamycin-related side effects?
1 to 5, minor to very significant
Overall, How would you rate your experience with Rapamycin so far?
0 to 5, Not Positive at all, to Extremely Positive
Overall, Given your experience with rapamycin so far, would you recommend Rapamycin use to a friend?
0 to 5, Highly Unlikely, to Highly Likely
How long did it take before you started noticing benefits and side effects (2 separate polls)
1 month
3 months
6 months
9 Months
1 Year
2 Years
3 Years
What other common health-condition medications do you take?
Antidiabetic agents
Analgesics (pain relief)
ACE inhibitors (high blood pressure)
Lipid-lowering drugs (high cholesterol)
Antidepressants/Anti-anxiety Medications
Proton pump inhibitors (reduce stomach acid)
Beta blockers (high blood pressure, heart disease)
Sleeping aids
Estradiol (Estrogen Replacement)
Other
What other prescription longevity medications and treatments for longevity/health to you take or do?
Metformin
Acarbose
SGLT2 inhibitors (canagliflozin, empagliflozin…)
Viagra / Cialis / Tadalafil, Sildenafil
17-Alpha Estradiol
GLP-1 agonists (Rybelsus/Semaglutide, Wegovy, etc.)
Low Dose Naltrexone (LDN)
Senolytics (Dasatinib)
NAD+ injections
Peptides (MOTC, SS31, etc.)
Testosterone Replacement Therapy (TRT)
Blood Donations / Plasma Donations
Plasmapheresis
Other
What other Longevity Supplements (capsules, tablets, powders, etc.) do you take regularly?
Alpha-Keto Glutarate (AKG)
Astaxanthin
ECGC
Curcumin
NMN (nicotinamide mononucliotide)
NR (nicotinamide ribosome)
Trimethylglycine (TMG)
Quercetin,
Fisetin
Collagen Protein
Coenzyme Q10 (CoQ10)
vitamin C
Ergothionine
Apigenin
Vitamins A-D-K
Acetyl-L-carnitine
Lipoic acid
Lithium (micro dose)
Glycine
N-acetylcysteine
Pterostilbene
Malate or malic acid
Magnesium
Trehalose
Glucosamine
Plasmalogens
Hyaluronic acid
Ginger
Ashwagandha
Resveratrol
Sulforaphane
Moringa Powder
Theanine (L-theanine)
Bacopa monnieri
Tumeric
Piperine
PQQ (Pyrroloquinoline quinone)
Exogenous Ketones (Juvenescence, etc.)
Rhodiola
ribose, D-ribose
Inulin
Fucoidan
Combination Longevity Supplement Products (e.g. NOVOS, Protandim, etc.)
How Frequently do you do blood testing to see changes in key blood markers (LDL, HDL, CRP, etc.)
Every 3 months
Every 6 months
Every 9 Months
Every Year
One Year +
What is your typical dosing - in terms of mg/kg/wk:
(include some tables for typical dosing range and weights to make this easy for people to estimate)
< 0.05mg/kg/wk
0.05 to 0.1mg/kg/wk
0.1 to 0.15mg/kg/wk
0.15 to 0.2mg/kg/wk
0.2 to 0.3mg/kg/wk
Over 0.3mg/kg/wk
What version of rapamycin / rapalog do you typically use?
Pfizer Rapamune
Glenmark Pharmaceuticals Sirolimus
Zydus Siromus
Biocon Rapacan
Rocas Sirolimus
Panacea Biotec - Siropan sirolimus
Actiza Sirolimus
Dr. Reddy’s Sirolimus
Sirolimus from a compounding pharmacy
Everolimus
Temsirolimus
How much (total cost) are you paying for your rapamycin per 1 mg tablet (or equivalent) approximately?
$0.50
$1.00
$1.50
$2.00
$2.50
$3.00
$3.50
$4.00
$4.50
How do you typically take your rapamycin / rapalog?
With grapefruit juice
Olive oil, or other fatty meal?
Empty stomach,
Morning
Evening
Do you follow any specific strategy to increase the bioavailability / dosing response of rapamycin?
Take it with…
Olive oil, or other fatty meal?
With grapefruit juice
Ketoconazole
other CYP3A inhibitor (e.g. parsley, etc.)
How would you describe your diet on most days:
Vegetarian
Vegetarian/Pescetarian (vegetables & fish)
Mediterranean
Ketogenic
Low Carb
Paleo
Carnivore
Vegan
Typical American Diet
Other
Do you follow a specific time restricted feeding strategy?
No , I don’t follow a food timing strategy
One Meal A Day
Fasting (1 day or more per month)
Time Restricted Eating / Feeding
Fasting Mimicking Diet
Other