@Nebil, I have psoriasis and ‘maybe’ psoriatic arthritis. I say maybe because of other health complications, and lazy rheumatologists. I was on Methotrexate for 8 years and experienced diminishing returns; pain, flares, dry, fragile skin, fatigue, etc.; I had a bad reaction to prednisone and grew frustrated by doctor’s lack of interest in alternatives. More methotrexate, more prednisone!
I was on Rapa Nui in April, literally looking into the crater where it was discovered, and had a light-bulb moment (cue the woo-woo music) regarding trying rapamycin on my own, as an immune modulator, trial of one. Reign in my auto-immune condition and maybe add in some positives as well?
I slowly worked up to 4mg a week and felt pretty bad, just too many side effects for someone who was already sick. I’m now taking 1 mg daily; am going to try @desertshores protocol: 7 days on 7 days off… already on the 1 mg a day dose I feel much better.
I have a stack of supplements I’ve been fiddling with for years, and will continue to do so with the goal being refining them to the most useful. No one like taking 30 pills a day…
There’s a lot of fear on the forum about rapa’s immune suppression; but what is methotrexate but an immune suppressor? Not to mention prednisone! People are put on these powerful drugs for life and accept it like sheep. Baaaaa, humbug.
I live in Africa, surrounded (kind of, I live on an isolated ranch) by poor people with active TB and gawd knows what… It’s a middle-income country, so good docs, just not enough of them, and I’ve survived Africa, COVID, vaccines and boosters, lots of travel. I drink untreated water from a (deep) borehole and get regular minor injuries based on lifestyle (conservation, wild animals). I recently attended the annual Kasanka, Zambia fruit bat migration (10 million bats converge on a small forest) and people said - Oh, bats! Aren’t you concerned about viruses - ??? Yeah, no, it was one of the most amazing experiences of my life. Definitely worth dying for. Highly recommended.
Frankly I was more concerned for my health risks last March in Bolivia… So poor, lots of malnutrition, cholera, etc.
I don’t see why rapamycin would have more infectious risks than standard immune suppressants. My docs like to say that methotrexate is a safe drug because we’ve been using it for 50 years and we know what to expect. Except for those pesky diminishing returns. What good is a ‘safe’ drug that doesn’t really work?