Make sure they are providing enteric coated pills.
Otherwise, you are guessing the dose.
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Enteric coating doesn’t matter. It’s suspension in nanoparticles or similar for improved solubility.
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Yeah… get that!!!
Hahaha.
Beware… compounded just doesn’t seem to work it seems.
I have had the whole lot.
Hard triangle shelled red lettered RD 54 Sirolimus…
Rapamune
and now Zydus round pill 21.
They all work because every 4 months or so, I get a trough blood draw. Typically under .6 or so.
Then, take a dose … then another blood draw at 2.5 hours. Get approx 3ng/mL per 1 mg of rapamycin.
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Appointment of Joan Mannick as CMO is a sign that company’s cellular rejuvenation programs may be nearing readiness for human studies.
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Zydus round pill 21.
Is it not coated? Helped a friend buy Rapamycin from India, paid up for Zydus ($1 a pill for 1mg).
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Hey Jonas,
The Zydus 21 pills… have suspension in nanoparticles.
Unlike the yellow triangle hard coated rapamycin/siriolimus/rapamune pills.
Zydus is totally potent in its design as my Labcorp test shows this week.
Pure rapamycin at 1 mg delivers 3 ng/mL in the body.
So last week my 8 mg dose should yield about 24 ng/mL and it does… plus! See below.
Zydus khaki colored pill delivers full potency.
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Thanks Agetron, relieved to know!
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Imagine if an OTC supplement that has been available for years turns out to be the cure for Alzheimer’s
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Hi Agetron, how many hours after ingestion did you draw blood for analysis ?
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Taking a blood sample 2 and a 1/2 hours post dose will give you the c or t-max. No sooner than 2 hours… and up to 3 hours post dose is fine.
That has been consistent with most people including Matt Kaeberlein. If your rapamycin is good you can multiply your dose by 3. That should be close to your ng/mL number. For example, 6 mg rapamycin should be 18 ng/mL on your Labcorp test… 2 1/2 hours post dosing.
Post rapamycin dosing at night, when not measuring it… I feel a bit off and slow til noon the following day. FYI.
Hope the rapamycin is helping. Also, Creatine Monohydrate (a couple spoons full) is suppose to give you a bit more energy, and clear mind. I find this to be true.
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This will stop any tooth infection immediately. The syringe has soft bristles that go under gum (approximately 1 mm deep). Inject only a few drops. Don’t swallow. Instead of bristle applicator a thin bent cannula can be used.
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I’ll keep that in mind. I actually went pretty good reintroducing rapamycin. I feel great, and no side effects.
Here is a writeup I did on all the changes I made to fix the issue:
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Hello,
I’m not sure if this is the right place to ask this question, but I am thinking about buying some tablets that are not enteric coated. I have heard that there is less benefit, but was wondering if I can put them into an empty enteric capsule and that might help. Does anyone have any experience with this?
Thank you,
Sydney
Enteric coating does not matter for bioavailability, it’s solubility with e.g suspension in nanocrystals. So enteric capsules don’t work.
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The 2.5 hrs checks very well with me, but I get a lot more than 3ng/l from 1 mg. This was taken at 14 mg of standard Rapamune solution from Pfizer, no GF or other inhibitor
Pik 3 Curves 14 mg Feb March 2025.pdf (90.1 KB)
If you are interested in more Details : People pushing the upper limits of Rapamycin Doses - Any One Else? - #171 by Maxi
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Rapamycin is being researched more extensively in China these days, as the country has fewer bureaucratic hurdles for new experimental treatments. I expect China will have more medical breakthroughs than we simply because they have much less hesitation in all sorts of experimentation. And AI certainly will aid them in that, too.
There is a database from China that I occasionally browse through. Some of you may be interested in mining your own info here. Search-CNKI
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The problem is that many Chinese studies are falsified. The rate is 50%. So you can never take a Chinese study at face value. You need multiple sources to confirm results.
With a 50% rate of falsified studies, how can you trust any scientific results out of China without confirmation from a Western or other reliable source.
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I think Chinese biotech and drug discovery have improved, based on recent deals: US pharma bets big on China to snap up potential blockbuster drugs | Reuters
I think it’s a judgment call for some of their research. Always follow the motives. Some of the research done on rapamycin is not driven by publication and research grants, but by the desire to cure.
In the longevity space, China is also quite prolific.
Alphabet’s Calico stitches $596M deal for Mabwell’s anti-aging asset
By Gabrielle Masson Jun 26, 2025 4:52pm
Calico Life Sciences, an Alphabet (Google) longevity biotech, signed an exclusive licensing agreement with Shanghai-based Mabwell Bioscience. The deal, valued up to $596 million, gives Calico global rights (except Greater China) to develop and commercialize Mabwell’s investigational IL-11-targeting monoclonal antibody for age-related diseases. Calico paid a $25 million upfront fee, with potential milestones of $571 million tied to development, regulatory, and commercial outcomes. Mabwell’s drug candidate targets interleukin-11, implicated in aging and fibrotic diseases, and has completed Phase 1 trials in China and Australia.
https://www.fiercebiotech.com/biotech/alphabets-calico-stitches-571m-deal-mabwells-anti-aging-asset
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The hard part is finding which studies to believe or not. Not all research out of China is bad, but the bad research makes it hard to find the good research. I’ve been burned a couple of times buying supplements (ex. grape seed extract) that was based on fraudulent research before I learned about how bad Chinese papers are.
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