"Nanomedicine approaches for sirolimus delivery: a review of pharmaceutical properties and preclinical studies"
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Damn…I found this article VERY interesting. I had no idea so many different types of nanoparticle technologies had been developed. However, if I interpret the article correctly, these nanoparticle formulations are not yet being utilized in generic sirolimus drugs from various generic drug companies…
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@RapAdmin curious, which Indian brand did you choose to use? Also, are you concerned with non- nanoparticlization, as mentioned in the comments?
Thanks
So - based on the results of the small lab test on a few batches of Indian generics - I’ve been buying Zydus and Biocon. Again - small sample size, so my confidence level in these providers is moderately high, but not extremely high. But, given that the Indian generics are $1/mg or so, vs. the typical price of $4 to $6/mg retail/street price of Pfizer name brand Rapamune, for me I feel the best choice are the Indian generics for price/performance.
The nanocrystal technology that Pfizer uses in the rapamune / sirolimus product provides about a 30% increase in bioavalabilty according to the research we have at the below link. You can get about the same increase in bioavailability (we believe) simply by taking the generic sirolimus with a fatty meal - as outlined in the Rapamycin Bioavailability discussion in this post. So - that is what I do:
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The results are pretty impressive and I like the idea of just taking it with a fatty meal.
Any particular company that you prefer for price,delivery, ease of communication, etc?
I have zero allegiance to any of the rapamycin online stores, in fact if anything I have a bias towards trying new ones just to test out the purchasing experience from the different vendors. I’ve purchased from about 6 of the vendors listed on our “reliable online pharmacies for rapamycin” and they’ve all come through, no hassles, with deliveries between 2 and 4 weeks from order date. Every time I order, I get price quotes from numerous vendors, and then make my decision. Prices can vary a lot over time even from the same vendor.
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Okay, good to know. I’ll take a look.
Looks like Biocon is in trouble for bribery.
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I have been taking for almost a year love my supplier! He takes care of my tribe! This is excellent news!
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Just curious how much lab tests cost using valisure?
It used to be a few hundred dollars, but now they’ve stopped doing lab tests for individuals, so as to focus on their own in-house pharmacy (that tests all the batches of drugs before shipping them out).
Any suggestions for alternatives in the US?
No, but I’ve searched… Its easy enough to search on “analytical lab” in your city, but they are typically expensive ($700+) for a compound analysis. I think that @Mac found a good one in Toronto, Canada that he used for some rapamycin powder he purchased - perhaps he can share the details (you can private message him in this forum). The more data we can get the better! Please post any results you might get.
Has the non-Sirolimus peak in the Biocon been identified? I am interested in ordering the Biocon because its cheaper but that other ingredient concerns me. It seems like many of you all are using Biocon and must not be very concerned about this, so i’m wondering if i’m missing something that everyone else is aware of? is there a reason I should not worry much about this?
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Not to my knowledge. I don’t think anyone else has done any testing (or at least reported any testing). Definitely an area were it would be nice to have more data, but its expensive for the analytical lab analyses.
I’m wondering how people came to the conclusion that it’s safe enough to take, considering how many use it on this forum.
I think the general test results were pretty good for most people, with the one question mark around the filler / extra spike.
I don’t know, but Biocon 1mg tablets have a little more filler material than the 1mg Zydus brand tablets and are slightly larger than the Zydus brand. Both of the white 1mg tablets contain titanium dioxide, a commonly used food, and medicine whitener.
I have used both effectively.
So it could be filler, which may be innocuous? Thank you, I didn’t realize that. I was assuming the test results pick up active ingredients and therefore potentially dangerous and / or toxic. I listened to an interview with the author of Bottle of Lies and there was at least one antidote of a generic that had a toxic agent and that is what came to mind.
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I have been getting multiple quotes for sirolimus 1mg tablets from many sources on IndiaMart. Lowest is consistently Siroboon1 (was Sirokem) by Kachhela, then Rapacan by Biocon, and highest is Siromus by Zydus at about twice the price.
I was favoring the Biocon or Zydus due to the above posted positive lab test quality reports, then decided to ask about lab reports for the Kacchela Siroboon1. I was surprised to be sent a quite recent lab report by Iosis Remedies PVT Ltd, which indicated very positive analysis with an Assay result of 1.0089 mg.
I shall be ordering 300 Siroboon1 tablets tomorrow for the family direct from Kacchela Medex.
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