Siroboon Lab Blood Test Results

Valsko writes:
A primary reason for taking periodic high doses is to get better penetration across the BBB. However, there’s also something called the blood-labyrinth barrier which protects the sensory epithelia of the inner ear.

Matt, in his latest interview on the Drive with Attia and Sabatini - says getting across the BBB may be easier for older adults as the immune defense weakens… he also says peripherally and on the outer area of the brain, the benefits may be enough without crossing completely through or in.

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I don’t know if this has already been brought up, but I lab tested Siroboon 1mg 12 months ago, and each tablet had 1.65mg.

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Can you please post the actual lab test results… a PDF uploaded if you have those, or details on the test, etc.

Sure. Actually, it’s closer to 1.65mg per tablet.

I’ve attached it.
sirolimus-siroboon.pdf (228.9 KB)

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On the one hand, thats good value for the money, in this one tablet or batch of tablets.

On the other hand, a quality control system that allows that wide a variance from the mean (.i.e. +/- .69 of a mg, or in other words about +/- 70% of target dose), suggests that some significant part of the time you may be getting something like .3mg or .4mg instead of 1mg. I find that disconcerting and problematic as you would never really know what dose you’re taking.

And, if they have that wide a standard deviation in the dosing, how much can you trust them on the possible contaminants?

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This was posted last year:

Original post:

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Kachhela also sells Siroboon 2 and Siroboon 3.
Siroboon 3 is 3mg pills. Last I knew, price was around 36¢ per mg.

Has anyone tested blood levels to see if they correspond to the dose they think they are taking of Siroboon tablets? I’m curious both as to the accuracy of the tablet amount but also if their are any differences in absorption (per brand) due to different enteric coatings.

There were results posted. But one problem is that people were possibly having their blood drawn too soon, trying to catch a peak that only applies to rapamycin liquid preparations on an empty stomach.

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yes, probably would need a direct comparison of 1mg zydus brand and 1 mg Siroboon brand. I guess another reason that it is worthwhile to test your own blood level on the dose you are taking to determine if your in your own personal target range.

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I’ve been taking the Biocon Rapacan 1mg pills for almost six months. I take 8mg every Friday morning. Three times I’ve tested my rapamycin blood level, all of them two hours post consumption. Test 1 result was 17.1 ng/ml, Test 2 was 12.9 and test 3 was 31.9 (with GFJ). And, I’m getting good results (check out my hair picture on the Anti-Aging Benefits thread).

Two months ago I tried the Siroboon 2mg pills (fewer pills seemed easier and cheaper). I took four 2mg pills and my blood test came back at a paltry 3.1 (also after two hours and posted results on this thread). Quite disappointing.

Yesterday (Friday), I tried the Siroboon again, taking four 2mg pills (maybe the first time it was something with my digestive system or a bad test?). I then had my blood tested twice- once after two hours post consumption and again after six hours.

Two hours: 3.8 ng/ml
Six hours: 3.2 ng/ml

My take: Siroboon = SiroCrap

I’ve bought everything from Maulik at Vallabh Enterprise/Shreeji Impex and I’m certain that he is sending me unadalterated Siroboon. I’ve bought a bunch of stuff from him and all of my tests show that they have worked as advertised. Maybe I just got a bad batch? I couldn’t excuse that either.

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I bought my Siroboon directly from Kachhela and got similar results (posted up-thread) where two 10mg Rapacan tests showed values of 40+ and Siroboon came in at 8.9. (I weigh 120lbs.) All at nearly the same time, and with same food intake. I never tried the rest of my Siroboon after this, stuck with Rapacan.

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Yes - I think that there is likely a significant difference in quality control in these companies. I would stick with leaders in the market in India. In this case, we’re talking Zydus and Biocon for sirolimus.

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QC or there are differences in the enteric coatings between the different manufacturers. I wonder has anyone compared Biocon to Zydus in their blood levels post ingestion?

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Ugh, I would have tested, but labcorp in MA may refuse to process siroboon testing, ugh

and I loaded myself up on A LOT of siroboon

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Hey Dan,

I am curious on zydus too. I dId a blood draw last week. Took 4 mg zydus and 5 oz. fresh Red GFJ… drew blood 2 hours after for a labcorp test.

I will have results in a few days and I will post.

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Unfortunately, it seems that 2 mg of Siroboon is equivalent to 0.2 mg of a normal Sirolimus.

Maybe they forgot the ‘.’?

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Can someone test this for heavy metals. Also can someone blood test this AFTER putting the pills through a pill grinder? It’s been shown that they do contain sirolimus - but the issue is one of absorbability

https://www.amazon.com/COOL-KNIGHT-Electric-Suitable-Medicines/dp/B0C4SJN8M7/

Mortar and pestle is the standard, I think.

I’m not sure why you’d want to grind the pills. You lose the enteric coating, if there is any.

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You know, someone once asked me (at vibecamp) are you concerned with the purity of the drugs you’re taking? (this made me go into a fugue [later in life] where I later obsessed over purity/air pollution/microplastics)

At the time, this tangent made me then obsess over Putin’s obsession with purity (both COVID purity and having people taste things for him before he eats them) AND his seemingly slow aging rate AND racial purity too…

He was not thinking about rapamycin at the time, but rapamycin… really… was the most important of them all (that, and dapagliflozin…) and anything from kachhela or indian pharmacies. I really ought to be better than this…

At some point in time (AGI timelines and infinite amounts of change from one small change in inputs/outputs will literally cause some people to do the same thing [wrt extreme levels of microplastic/chemical testing for ALL food they eat, and it’s probably SUPER-WORTH it for people who already have wealth, especially given the nanoplastics crisis [we cannot afford to take risks on stupid things] ]. At the very least, universal semaglutide reduces all total compute loss from microplastics)

[a small amount of impurity in some drugs can cause DRASTIC changes to people’s cognition]

Most people don’t appreciate this thesis enough, and are dismissive. We were dismissive of air pollution for many decades, and only now do we really see how terrible it is for us. We cannot afford the same risk for nanoplastics/microplastics. Sure, don’t raise your cortisol levels stressing over it, but like, at the very least, take semaglutide and do things on the margin to reduce plastic consumption

I know one person in longevity who ONLY drinks soylent (and avoids all impurities). He’s pretty strange, but he also is creative in strange ways.

I actually did get a small grant b/c I convinced some people that the microplastics thing is really important (on top of some other things), though the recent nanoplastics paper now shows that I’m not sure if testing microplastics is useful/helpful unless we can find nanoplastics (given that ALL historical estimates of microplastics were now gross uncertainties)…

And this is ALL important for global alignment because we cannot take stupid chances on human compute loss from lack of alignment, and yes, microplastics pollute our chances at alignment. Even davidad views microplastics/nanoplastics as significant enough to be of concern.

Sam Altman said that AIs will become capable of super-human persuasion before superhuman anything else. Perhaps AIs will be what finally convince humanity to really finally cut down on “dumb microplastics” (if AGI generates A LOT of near-wealth, the plastic alternatives/degraders will be even more fundable).

[pollution is also mimetic, can come from back pain, can come from wasted time, can come from trauma]…

Someone actually told me “think clean thoughts”, which was SOUND ADVICE. Too bad this is not ALL in my control yet, because I still historically had a lot of distracting thoughts that were irrelevant (tFUS, tFUS…)

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