Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model

#1

I missed this paper last year … more good news about Rapamycin’s impact on the brain:

These results indicate that rapamycin may play an important therapeutic role in inhibiting neuroinflammation by normalizing brain vascularity, BBB, and some brain metabolites, and has a high translational capability.

Abstract

Full Paper Here:

Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model

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Why Take Rapamycin? (part 2)
Rapamycin as a preventive intervention for Alzheimer’s disease in APOE4 carriers: targeting brain metabolic and vascular restoration
#2

Posting here this recently published study about rapamycin for dementias. The more I follow the research, the more I have the feeling that rapa can be very functional in medicine, but only if individualized with monitoring of biomarkers established at the baseline… For the brain, data is still very confusing for me.

Rapamycin treatment for Alzheimer’s disease and related dementias: a pilot phase 1 clinical trial

https://www.nature.com/articles/s43856-025-00904-9

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#3

This new paper is being discussed in the following thread:

  1. Rapamycin and Alzheimer Disease: a Hypothesis for the Effective use of Rapamycin - #6 by RapAdmin
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