Rapamycin reduces benefits of exercise in new study?

[JPKellysr]

I got this in an email yesterday from Donotage.org.

"So they took 40 people that did not exercise, aged 65-85, and gave half the drug and a placebo, and made them do exercise.

Both groups improved (expected when exercising) but the placebo group improved more.

6 minute walking test, grip strength and chair-stand reps - all 3 physical tests showed better performance in the placebo group.
Also, the rapamycin group had around 100 side effect events, compared to only 63 in placebo group."

Link to study
Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA‐EX‐01 Randomised, Double‐Blind, Placebo‐Controlled Trial - Stanfield - 2026 - Journal of Cachexia, Sarcopenia and Muscle - Wiley Online Library

[qBx123Yk]

Full discussion here: Update on Brad Stanfield's Rapamycin Clinical Study in NZ - #68 by RapAdmin

[Cole]

I posted a completely unbiased analysis. It takes a lot of courage to post negative feedback on a biohacking forum, you should go take a look.

Update on Brad Stanfield's Rapamycin Clinical Study in NZ

1. Primary and Secondary Efficacy Data: Functional Performance The hard data indicates that over the 13-week period, administering weekly rapamycin did not enhance exercise adaptations; instead, it actively attenuated the functional gains derived from the exercise program. Primary Outcome (30-Second Chair-Stand Test): * Intention-to-Treat (ITT) Analysis: Both groups improved, but the rapamycin group completed an average of 2.13 fewer repetitions compared to the placebo group at 13 weeks (p=0.089). Per-Protocol (PP) Analysis: Among participants who strictly adhered to the exercise and dosing schedule, the negative impact was statistically significant, with the rapamycin group completing 3.44 fewer repetitions than the placebo group (p=0.007). Objective Takeaway: The data demonstrates a clear, negative dose-response relationship: strictly adhering to the rapamycin regimen resulted in significantly worse lower-body functional improvements compared to exercise alone. Secondary Fu…