Rapamycin + Metformin + Rosuvastatin + Dihydromyricetin stack

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#1

As several others on this forum, I’m aiming to take advantage of potential benefits of rapamycin, while minimizing the potential impacts on glucose and lipid parameters. Please share your thoughts on my current conservative protocol below (which is aimed at general health and longevity)

  • Once-weekly Rapamycin (Sirolimus 5mg)
  • Once-weekly Rosuvastatin 5mg + Bempedoic Acid 180mg + Ezetimibe 10mg
  • Twice-weekly Metformin 500mg
  • Dihydromyricetin (DHM) each time I take any medication

Notes:

  1. In the past, I used to take (Rosuvastatin 5mg + Bempedoic Acid 180mg + Ezetimibe 10mg) on a daily basis, which did a phenomenal job of keeping my LDL-C under 50 mg/dL. However, my HBA1C and liver enzymes were going in the wrong direction. Also, I feel like my immune supression/impairment is compounded along with the effects of rapamycin (I’m not sure about this, but just noticing my general susceptability to catching a cold flu, but this doesn’t occur very frequently). For these two reasons, I’m now considering reducing the frequency of these lipid lowering medications (to once weekly). I’m yet to measure my LDL-C (or ApoB) levels on this reduced frequency dose, but my guess it that it will be around 80 mg/dL (considering that I follow a high fibre diet, add psyllium husk, ocasionally take berberine and follow a high activity lifestyle). 80 mg/dL is a level I would be comfortable with. If I don’t take lipid lowering medications, my normal LDL-C would be around 120-130 mg/dL.

  2. The reason for adding metformin 500mg (which I take along with rapamycin) is to mitigate any potential glucose disregulation. And I’m only taking this on the day of taking rapamycin + the next day (with the idea that half life of circulating sirolimus levels is matched with half life of circulating metformin levels). My current HbA1c level is quite stable around 5.5% (I’m aiming to bring it down to 5.2% or less). I’ve been using a CGM lately, and my glucose regulation has much improved compared to the past (mostly due to better dietary and exercise habits). I would like to hear your thoughts on whether metformin 500mg twice a week is sufficient to mitigate any potential downsides of rapamycin.

  3. I started taking Dihydromyricetin (DHM) after listening to a podcast with Sandra Kaufmann. My idea of using this is to mitigate any liver toxicity from taking these medications. I’m yet to re-test my liver enzymes. So, at this point, I’m not sure if DHM is making any difference for me.

  4. FYI. I’m a 46 year old male, quite lean (about 15% body fat), following a good diet (high fibre, high protein, low-GI), 14-hour fasting window, sleep, exercise & Infrared sauna routine.

Your comments and personal experience / findings / research citings will be appreciated.

Thanks,
San

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#2

Raisin Tree (DHM) is an HDAC inhibitor that is also helpful in reducing the harm from ethanol.

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#3

I take Rapamycin bi- weekly on Wednesday 5 mg - I do not take Metformin (500) for 2 days then start back with Metformin on Friday. I Cycle Amino Acids on off week of Rapamycin. DHM daily in the morning. Allows to still maintain/build muscle but incorporates the anti aging benefits- this was based on a consultation with Dr Kaufmann. Not to mention the other some 30 supplements.

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#4

Thanks John. Any reason for skipping Metformin on Wed & Thu? (I assume you take it on all days, expect for 2 days around taking rapamycin)

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#5

Thanks, San.
I have somewhat similar and free style protocol. Was suspicious of statin benefits for years. Now I will take them for a year and then reevaluate. I am retiring cardiovascular physician, did a lot of clinical trials.

Rapa once a month, 3mg with grapefruit.
Crestor 10 and Ezetimibe 10, 2-3 times per week, usually with heavier food.
Metformin 500 3x per week, when not exercising or taking Crestor. Taurine when exercising.
NAD+, Quercetin, Resveratrol, Lithium 2x times per week.

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#6

Why not an SGLT2i on daily basis instead of metformin for the same effect and cleaner targeting and i would say metformin is good for the down regulations of IGF-1 conversion in the liver not the suger properties ( expressing my cause won’t change the effects but just to be more precise lol)

#7

Why not take Milk Thistle instead as it has many more studies have done on the supplements? In Germany, doctors prescribe Milk Thistle for liver protection.

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#8

for me SGLT2i did not sit well with me. weakness/tired in general and a bit of muscle pain. Metformin I handle just fine with no side effects.

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#9

Thank you. I’ll explore this

#10

Any reason for skipping Metformin on Wed & Thu? (I assume you take it on all days, expect for 2 days around taking rapamycin). Thanks

#11

i’d have to go back and see if I can find my specific notes. I think it had to do with the fact that I was doing things that are anti-aging while at the same time I was doing things where I was trying to build muscle. she said that it was working against each other and impacting my ability to build muscle. Which metformin can have an impact to some degree.

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