Okay - so I have the extra Rapamycin from my prescription to make a hair tonic and I am shopping through Walgreens for pure oil free face cream and Transcutol. And then it hits me. Generic Rogain - Walmart 5% minoxidil. It is a clear liquid solution for the scalp (unlike a cream) - ingredients made to last a few months. Why wouldn’t a person powder up the Rapamycin and mix with this solution to dissolve and spread it evenly and cleanly on the scalp. You get the benefit of blood flow increase at the follicle root with the minoxidil and that can provide a path for the Rapamycin to do it’s magic within the roots. Kinda makes sense to me. I have my hair, but it can always be a bit thicker. For those with exposed - bald heads - the face cream approach might make more sense. I have a prescription for the Sirolimus .2% cream for my neck and face. Lasts a few months. I get it a CareFirst in New Jersey. One year of use and it is amazing. Turkey neck gone - face tighten - brow lines gone. I tried the cream on my hair at night - a mess and probably loss more hair than I gained. LOL So, I am going to try my idea out. Powder the Rapamycin and add to the Equate 5% Minoxidil. Will take scalp pics before and pics again in 3 months. Let’s see how my personal trial goes.
Full Paper:
Update.
Just got back from a haircut. My regular hair dresser past 3 years. . point blank asked me… "Are you using a supplement on your hair? I asked a supplement… what do you mean?
She said Rogain… or something.
She told me the back of my crown has new growth and it’s curly growth.
I laughed and said yep for the past 10 days or so.
Hmmm… lets keep going with that!
Just took this… will do a 3 month before and after pic.
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I’ve been doing the same thing for a month or two. Can’t tell if any new growth, but my front hair seems to be growing thicker and better than ever. I’ll have to get more serious and methodical about quantifying somehow, but anecdotally, it seems to be doing something positive.
Update! Well it has been 3 weeks since my last hair cut and time for a hair cut again. My stylist said you definitley have new hair coming in on the crown and in the front. She called over 2 other co-workers who confirmed. Then asked, Please tell me what you are doing, so I can tell it to my husband. LOL.
Using 5% equate (Walmart brand) minoxidol liquid with 4mg rapamycin (2 pills) crushed in it. Use at bed time and in morning after shower religiously. When I started… it seemed a lot of hair was falling out from the treatment. I was warned this happens for the first few weeks… then stablizes. So fair warning… it gets worse… then better. Hahaha.
Great news - thanks for sharing! I’ll need to try this.
I also wonder if perhaps adding 17-alpha estradiol to the mix might be beneficial - as per this patent on the use of it on skin (and its already sold for hair growth in Europe).
Sounds worth trying. Easy enough to add.
Based on user experiences being reported on this site, what concentration of rapa topical are yielding the best results?
Thank you!
@Agetron are you using the rapa topical to face and neck daily?
I also have a script for Carefirst pharmacy. They told me it is shelf stable for only 1 month in the standard base they use (because it contains water). They do tho have a water free that lasts 6 months but may go on more like aquafor. Which do you get?
Thanks!!
I have success with .2 percent compounded at pharmacy with a prescription. Great on neck and forehead…criws feet wrinkles.
So this intervention was BOTH Minoxidil AND Rapamycin?
If so, how do you tease out Rapamycin only?
Minoxidil REALLY works…I have some balding on my crown, my hair doc put me on a solution of Minoxidil combined with Bimatoprost and topical Finasteride, applied nightly.
Astounding hair regrowth in only 2 months.
If anyone is doing a methodical Rapamycin only intervention please share.
Mine is a white lotion cream… lasts about a month … I use at night and after shower in the morning.
FWIW…
Add some retinol{Vitamin A
The additive effects of minoxidil and retinol on human hair growth in vitro
Sinclair mentions adding retinol to minoxidil in one of his podcast series he did at the beginning of this year {2022]
Indeed, my cocktail also includes Retinol (omitted).
MAC wrote: So this intervention was BOTH Minoxidil AND Rapamycin?
If so, how do you tease out Rapamycin only?
I don’t tease it out… it’s a combo treatment. Would it do the same with no Rapamycin? I don’t know. Just decided to use both…
I take 2 - 3 2mg tablets… crush them with neeedle nose pliers in a folded zip lock sandwich bag (so as to not cause powder to leak out)… pour it into the minoxidil and shake bottle good before use with dropper… just use on my front and crown. Brush it in with a good few strokes to stimulate scalp.
Right, so we don’t know in your n=1 experiment if it was Rapamycin.
Whereas it’s clinically proven Minoxidil does work.
Next go around, do Rapamycin only.
Add some DMSO as the carrier, rapamycin will dissolve very well and transport through the skin
I have the extra pharmaceutical Rapamycin to use… so I did… my prescription is for 1 pill daily… I dont do the that… I do 5 pills weekly… so always extra.
Dimethyl sulfoxide thanks for the tip!
On another thread, I upload a PDF copy of a medical book on DMSO titled;
“Dimethyl Sulfoxide (DMSO) in Trauma and Disease” by Stanley Jacobs