Yep… 65 years… pubs and arm pit hairs are brown… not grey.
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I use M. S. Traders. The most recent shipment arrived in 10 days. Prices have always seemed lower than the average reported on this site. I’ve ordered twice with them with no problems. Here’s their information.
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@RapAdmin, my order of 250-1mg biocon rapacan pills from Apple Pharmaceuticals via India Mart arrived today without incident. It ended up being 15 days from the day I made my payment. I’m very pleased with their service.
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Hi, I’d like to update this thread with this data: Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin - PMC
It’s about two case reports of people using topical metformin (10%!) for hair growth.
I think @Agetron should increase the potency.
A 30% topical formulation has been tested for the treatment of melasma see link below: Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman's formula) in treating melasma: A randomized controlled study - PubMed
Time to add a good dose of metformin to the rapamycin skin cream?
I genuinely find this stuff so cool, wtf.
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I think you are right… I have a bottle of Metformin pills that I don’t use… having switched to Acarbose.
Time to up the Metformin percentage.
Thanks.
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A couple studies for my fellow balding comrades.
Topical tretinoin 0.025% has been shown to increase hair growth.
Topical tretinoin 0.1% increases the efficacy of 5% minoxidil.
Topical cetirizine 1% (10mg/mL)
Topical spironolactone 1% (10mg/mL) and 5% (50mg/mL)
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I’ve come across a few interesting grey hair reversal links that I thought I’d share.
The 1st is a redditor who posted before and after pics of his beard regaining colour. He claims to use a red light face mask in addition to a bunch of longevity supplements and protocols yet rapamycin doesn’t appear on the list: Reddit - Dive into anything
The 2nd is a recent study that supports the theory that melanocytes don’t die off but rather stop functioning: Aging melanocyte stem cells and gray hair | National Institutes of Health (NIH)
"The team discovered that McSC differentiation was triggered in the hair germ by molecular signals from nearby cells. But in the bulge region, these signals were suppressed… The researchers observed that as the hair follicles aged in older mice, more and more McSCs stayed put in the region between bulge and hair germ. These could not become either new mature melanocytes for pigmentation or functional McSCs for later rounds of hair pigmentation.
The authors postulate that these ‘stuck’ cells may help explain hair graying in older individuals. “It is the loss of chameleon-like function in melanocyte stem cells that may be responsible for graying and loss of hair color,” Ito says.
The findings also suggest that if this McSC movement could be restored, it might prevent or reverse hair graying."
The 3rd Bryan Johnson’s Blueprint longevity experiment where he claims he has experienced significant reversal using his own concoctions that he plans to release to the public:. He takes a myriad of supps and I couldn’t see rapa there either: Monthly Notes — blueprint
@RapAdmin aware that these links don’t involve rapa, so feel free to delete if considered irrelevant.
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They used 10% metformin.
Have been on it two weeks, combined with AKG.
The paper below says it is the autophagy that regrows hair. They have tried AKG and oligomycin, applied topically, on aged mice.
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I believe this is relevant due to the fact that Rapamycin mimics fasting and turning off Mtor. This is exactly what dhannyboyd may be talking about since they are doing one meal a day or intermitent fasting which is what Bryan Johnson is doing. So taking Rapamycin can reverse grey hair but anything that turns off Mtor does the same thing.
Your thoughts?
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It is because the cells are more efficient that this happens. Rapamycin in inhibiting mTOR encourages autophagy. When cells recycle the mitochondria they become more efficient.
In 2 years of rapamycin use, I’ve seen no reversal of my grey hair.
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He seems to only update changes to his protocol in the monthly notes section. He has rapamycin on his list of supplements in the supplements/diet section - see here (right side of image) 13mg once every two weeks:
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Just to note - this is topical metformin they are describing, not the more typical oral consumption of metformin.
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Interesting I have the Platinum LED red lights. My experience is the opposite the make me happy!
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Looks like fisetin may also be a viable intervention.
Must give credit where it is due. I discovered that from a post at age reversal forum.
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Andrew Huberman did a deep dive on this subject in his podcast from 10th April. Well worth a listen.
Interesting was the point about topical Finasteride showing much higher blood stream concentration than oral. Makes me wonder if those using a Rapa cream on the scalp are also achieving higher levels in the blood so daily use might result in much higher trough levels than expected.
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FWIW
I have stated this in another thread.
Dissolve rapamycin in DMSO, paint your wrist area{the radial artery area] with this solution, You will absorb the rapamycin systemically.
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It’s possible, but I don’t think there’s a big risk. It would likely depend on the concentration of rapamycin cream that one would use, as well as what the rapa is dissolved in, ie. DMSO or Transcutol, which have different efficiencies of getting the drug into the bloodstream.
For example, the Drexel study used a 0.001% solution. This would be approximately 0.6 mg dissolved in 60 g of lotion. I seem to use around 1.5 g of rapa lotion per day, applying once at night before bed. This would correspond to 0.01 mg/day of additional rapamycin using the Drexel study concentration.
For my latest batch of face cream, I dissolved 16 mg in 60 grams of lotion (with Transcutol) for a 0.027% concentration. At 1.5 g, this corresponds to about 0.4 mg applied to the skin each day. Transcutol supposedly doesn’t allow the drug to be absorbed into the skin as well as DMSO, so the risk is low that it would increase trough levels. Even if you used DMSO, it’s tough to say if it would absorb the same amount into the bloodstream as taking it orally.
For my own N=1 experiment, I had my trough level tested a couple of weeks ago and had used the 0.027% cream the two previous nights. My trough level was 0.7 ng/mL, right within the normal range.
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We’ll done for testing for the benefit of everyone else here who uses a Rapa cream ( I don’t).
Back to the main topic heading, I thoroughly recommend anyone with a receding hairline who wants to do something about it to listen to that Huberman podcast.
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I am Rituparn
New to the forum. Is this red light a low flicker light emitting diode ,or otherwise
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