May I ask: If you went to the bank why didn’t you get an ACH transfer? It’s usually free or minimal cost, though it does take from 2-5 business days. I am surprised your bank didn’t recommend this as an alternative to the much more expensive wire transfer.
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They instructed me to do a swift transfer so I did so to avoid any issues. I may inquire about that the next time. Thank you for the pointer. I’m pretty new to all this beyond ordering various medications from ADC and in-house chemist for the last 8 years.
@desertshores
@blsm
I use Swift transfers via Wise with no problems so far. BTW, I order from IndiaMart/Well Easy Healthcare. Decent pricing, been reliable for me.
Two orders in the last 9 months including several meds in each. I have them split the shipment into packages around 150-180 pills to avoid attention. Costs me extra, but I get my orders.
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I do not dare to ensure that it is due to some supplement, but today I have cut this pubic hair, according to my calculations it has been around 35 days since it darkened again.
rapamycin 3 mg with grapefruit
5 mg lithium carbonate
3g glycine
2.7 g of aakg
150 mg of hyaluronic acid
1000mg glucosamine
and the most recent addition is 25 mg of captopril.
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Only one hair is getting darker or are many?
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What I have generally found is that although you can get new hairs growing that are pigmented normally strong white hairs remain strong white hairs. However, if I have a fine frail white hair that can turn pigmented.
This is a photo of my facial hair that I took just now. You can see how new follicles are working producing pigmented hair (in fact where I have not previously had hair), but the older ones continue producing white hair.
I have practically no gray hair, and this has been the only one.
Yep… 65 years… pubs and arm pit hairs are brown… not grey.
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I use M. S. Traders. The most recent shipment arrived in 10 days. Prices have always seemed lower than the average reported on this site. I’ve ordered twice with them with no problems. Here’s their information.
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@RapAdmin, my order of 250-1mg biocon rapacan pills from Apple Pharmaceuticals via India Mart arrived today without incident. It ended up being 15 days from the day I made my payment. I’m very pleased with their service.
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Hi, I’d like to update this thread with this data: Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin - PMC
It’s about two case reports of people using topical metformin (10%!) for hair growth.
I think @Agetron should increase the potency.
A 30% topical formulation has been tested for the treatment of melasma see link below: Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman's formula) in treating melasma: A randomized controlled study - PubMed
Time to add a good dose of metformin to the rapamycin skin cream?
I genuinely find this stuff so cool, wtf.
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I think you are right… I have a bottle of Metformin pills that I don’t use… having switched to Acarbose.
Time to up the Metformin percentage.
Thanks.
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A couple studies for my fellow balding comrades.
Topical tretinoin 0.025% has been shown to increase hair growth.
Topical tretinoin 0.1% increases the efficacy of 5% minoxidil.
Topical cetirizine 1% (10mg/mL)
Topical spironolactone 1% (10mg/mL) and 5% (50mg/mL)
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I’ve come across a few interesting grey hair reversal links that I thought I’d share.
The 1st is a redditor who posted before and after pics of his beard regaining colour. He claims to use a red light face mask in addition to a bunch of longevity supplements and protocols yet rapamycin doesn’t appear on the list: Reddit - Dive into anything
The 2nd is a recent study that supports the theory that melanocytes don’t die off but rather stop functioning: Aging melanocyte stem cells and gray hair | National Institutes of Health (NIH)
"The team discovered that McSC differentiation was triggered in the hair germ by molecular signals from nearby cells. But in the bulge region, these signals were suppressed… The researchers observed that as the hair follicles aged in older mice, more and more McSCs stayed put in the region between bulge and hair germ. These could not become either new mature melanocytes for pigmentation or functional McSCs for later rounds of hair pigmentation.
The authors postulate that these ‘stuck’ cells may help explain hair graying in older individuals. “It is the loss of chameleon-like function in melanocyte stem cells that may be responsible for graying and loss of hair color,” Ito says.
The findings also suggest that if this McSC movement could be restored, it might prevent or reverse hair graying."
The 3rd Bryan Johnson’s Blueprint longevity experiment where he claims he has experienced significant reversal using his own concoctions that he plans to release to the public:. He takes a myriad of supps and I couldn’t see rapa there either: Monthly Notes — blueprint
@RapAdmin aware that these links don’t involve rapa, so feel free to delete if considered irrelevant.
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They used 10% metformin.
Have been on it two weeks, combined with AKG.
The paper below says it is the autophagy that regrows hair. They have tried AKG and oligomycin, applied topically, on aged mice.
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I believe this is relevant due to the fact that Rapamycin mimics fasting and turning off Mtor. This is exactly what dhannyboyd may be talking about since they are doing one meal a day or intermitent fasting which is what Bryan Johnson is doing. So taking Rapamycin can reverse grey hair but anything that turns off Mtor does the same thing.
Your thoughts?
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It is because the cells are more efficient that this happens. Rapamycin in inhibiting mTOR encourages autophagy. When cells recycle the mitochondria they become more efficient.
In 2 years of rapamycin use, I’ve seen no reversal of my grey hair.
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He seems to only update changes to his protocol in the monthly notes section. He has rapamycin on his list of supplements in the supplements/diet section - see here (right side of image) 13mg once every two weeks:
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Just to note - this is topical metformin they are describing, not the more typical oral consumption of metformin.
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