Rapamycin for Hair Growth and Hair Pigmentation

My Finasteride/Proscar routine is take one 5mg pill every other day. It is built up in my system so can take it less often. Initially did one 5 mg pill a day . Since in my early 30’s… so for at least 30 years.

Great prostate gland size and health according to my urologist… small prostate.

Also, no issues with ED… or any side effects.

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Thank you. Great news for you!

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Wow. I didn’t realize that you were actually taking the Proscar dose (5mg) vs the finasteride (1mg)- you’re taking 1/2 the proscar dose, but, still, that’s a LOT. I don’t know if you have any potential downside at that dose for decades, but your dosing is certainly overkill if you’re only taking it for your hair. Because it doesn’t inhibit both receptors (like dutasteride does), you already max out on DHT inhibition around 65% on a much lower dose.

There’s research to suggest that even 1mg/day isn’t needed after the initial build up period. Many take just 1mg 3x/week.

I get the 5mg and use a pill splitter to cut it in 4ths for ~1.25/dose (I started doing this long ago when there was no generic propecia and 5mg proscar pills sold for much less per pill than 1mg propercia).

Anyways, like you, I’ve been taking this for like 25 years with ~7 of those years being 1.25mg 3x/week. My prostate is small as well.

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Yes. Why I skip the finasteride every few days…

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Age. Prior to the magic tonic you are compounding. What “hair loss” drugs were you taking? Seems like- Propecia + dose, we’re you on any oral or topical Minoxidil? Just trying to back into if Rapa had much of an isolated effect. The results since May clearly say that point forward something changed.

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To clarify.
I started finasteride at age of 33 because I noticed hair thinning on front and top… that stabilized my hair and some regrowth occurred. I would use Minoxidol 2% off and on for a few months over the years. Minoxidol made my hair dry and straw like and scalp dry too.

Prior to May 2022 was not doing anything for hair… except finasteride every other day. Had been on Rapamycin for 1 year 8 months at this point. Noticed arm and leg hair was already thickening… regrowing… due to Rapamycin.

My hair reached the point of noticeable thinning… like when I was 33 years. I decided to go on 5% Minoxidol now available… and kick it up a bit with rapamycin… added some DMSO to dissolve rapamycin and make it permeate the skin. Then added in finasteride and Metformin. This tonic… made my scalp itchy dry and flaky and my hair like straw.

Added EGCG and Resveratrol which was soothing to my scalp… and enriched my hair. I also started orally 5 mg Minoxidol in mid June. so about 2 months oral Minoxidol. Cut back to 2.5 mg when ankles swelled… after a month… Now back on 5mg. All good.

A staff member of 8 years… asked a few minutes ago if I was coloring my hair… he wasn’t sure as all my streaks were there… but the grey was blonde.

He said he really noticed because I was sitting next to a younger colleague with solid silver and white hair. He said the contrast in looking at us side by side made him realize how much younger and healthier my hair was… compared to the colleague. But my hair didn’t look dyed… all natural. Lol I explained my hair had a glaze from my tonic. He added… your bald spot on top is gone… yep!

I do think the topical tonic is helping with both the oral 5 mg minoxidol and 2mg finasteride - but even if the topical tonic is not adding hair - it is making my scalp feel better and I have this amazing rich colored, healthy hair - that looks 100% natural (streaks and all).Definitely going to keep using it.

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Awesome!! Rapa and oral Minoxidil seem to be change agents vs Propecia baseline you had used. Super results!!

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This is fascinating. I never knew I could take less finasteride. I have been doing 1 MG for a long time. I’m sure my hair has thinned since, but I started early and nothing is noticeable. Maybe I will switch to three times a week.

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Awesome!! Rapa and oral Minoxidil seem to be change agents…

It is really getting thick now.
I like the scalp benefits of the tonic. And, that natural shine and glow is like a young man’s hair.

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That’s awesome. The interesting part is it really appears to have regrowth with thickening, rather than just thickening.

I have started a Rapa headshot with the dmso. I’ll look to add some minoxidil.

Thanks for all your sharing. Great stuff. I’ll chime in after a month…

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Nice. Hoping you get the same success. I don’t want to be an N=1… be a 2!

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What is remarkable to me about your results is how quickly you have gotten good hair growth. Most of what I read says it takes 6-12 months to see results.

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When you finish your shower but before you put on the tonic (ie: freshly shampooed hair with nothing added), it the texture of your hair better than before you started the tonic, or is the change only when the tonic is in your hair? Also, is there any change in the color, or is the color enhancement 100% from the tonic being in it, and then washes back out?

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Indeed the results are great… I tend to respond well to most medications… like Rapamycin, finasteride, and such. No real side effects.

Today…top down on my sportscar… hair blows around and is thick, blonde… tousled… not balding.

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DyingSucks – When you finish your shower but before you put on the tonic (ie: freshly shampooed hair with nothing added), it the texture of your hair better than before you started the tonic, or is the change only when the tonic is in your hair? Also, is there any change in the color, or is the color enhancement 100% from the tonic being in it, and then washes back out?

Just went upstairs to take a pic of my shampoo. Nioxin. This cleanses super deep… gets all the scalp sebum out. After shampooing twice… my scalp and hair is squeaky clean. I do not put any conditioner on my hair… just shampooed… rinsed thoroughly with water.

I then towel dry…all over… and my hair feels great and the tinted color is still there… kinda stained in. I notice it seems to be cumulative with each application my hair is less grey and more blonde. Actually, I have no grey.

Tonight I caught my wife several times just staring at my hair…ummm… I think she’s confounded… she knows I won’t color my hair (she does)… and my silver is all blonde.

Certainly after applying the tonic… my hair is wet and slick…I let it sit a few minutes while lotioning my skin… bo juice and such…but after toweling the tonic in… my hair dries non-greasy, not oily… fluffy and very manageable when combed. My hair is definitely softer… like detangler because after towel drying… it combs with no snarls.

Unlike when I towel it dry after my shower and pre,-tonic… the front does tangle some… so I use a brush carefully.


Super soft right now bedtime… used tonic this am.

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May 1, 2022 OMG! Not only is my hair now thicker, healthier…but the residual material on my forehead skin has it less wrinkled and healthier too. An unexpected extra.

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another new up-and-coming hair therapy?

and for graying…

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FDA approves another drug for hair loss. Watch this youtube.

https://www.goodrx.com/conditions/alopecia/alopecia-areata-treatment-trials

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Looks like Bret King needs to use some of his own product. :smile:

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Both this paper and this one independently show that topical rapamycin of 2 μM concentration applied every other day promotes hair regeneration, While 16μM-20 μM actually prevents hair regeneration presumably due to excessive mTOR inhibition making the HFSC (hair follicle stem cell) unable to activate.

Based on the info in this page (in the ‘preparing stock solutions’ section) a 2 μM concentration is equivalent to 0.0002% rapamycin concentration, And the 20 μM which impeded hair regeneration is equivalent to 0.002%!

What this indicates is that 0.002% or even a 0.001% is counterproductive and is negatively impacting hair regeneration. The optimal dose is 0.0002% every other day like the study (Or 0.0001% every day), Maybe 0.0002% every day as a max.

In addition, These mice were not taking systemic rapamycin. So someone that taking weekly rapamycin might need even fewer concentrations or less frequent topical dosing (0.0001% every other day perhaps?, Or even less). Or maybe they don’t even need any topical therapy given how such a tiny topical concentration is needed for hair regeneration or even impedes it. So many questions.

However even those taking large doses of weekly rapa or even daily dosing still grow their normal hair. It’s not like it stops growing, So I’m not sure what’s going on. The whole thing is confusing.

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