I’ve also been wondering: What causes an enteric-coated pill to actually dissolve or release its contents in the intestines? Is it just that its there for so much longer than the stomach, and this eventually causes dissolution even at PHs closer to neutral, or is it some other property of the environment of the intestines?
" Turns out, pretty much all drug absorption occurs in the small intestine. This is because:
- Drugs spend longer in the small intestine
- The small intestine has a larger surface area"
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The idea is to get the drug quickly out of the stomach. The drug biaxin gives considerable GI gastric side effects and this isn’t alleviated by food. However, it’s very well tolerated when taken immediately with 8 oz. of water. I do the same with rapamycin to increase its transit.
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The enteric capsules (if they work properly) are pH-dependent. They resist breaking down in low-pH (acidic) conditions (stomach) and then open up in a higher-pH setting (small intestine). Taking w/small amount of water and no food would keep the stomach pH low and allow for rapid transit to the small intestine.
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If Rapamycin tablets are enteric coated and that delays absorption so it’s not affected by stomach acid, why is the suggested time for a blood test to see peak amount 30 to 60 minutes after ingestion? The peak is supposed to be very sharp and drop off rapidly. Seems that wouldn’t be the case if it was slowly absorbed in the intestine.
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If you have not seen, review this paper;
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Empty Acid Armor capsules are apparently not available to consumers. So I purchased a product, Syntol AMD(R), manufactured by Arthur Andrew Medical, that comes in Acid Armor capsules. I took a capsule apart and emptied it, and put a smaller capsule of 3 mg pure rapamycin plus cellulose into the Acid Armor capsule. I got the rapamycin from a compounding pharmacy; my physician was willing to prescribe it for me. This rapamycin product contains no dyes, no titanium dioxide, etc. I had my blood drawn by LabCorp about 2 hrs and 45 mins after consuming it on an empty stomach and had it analyzed for rapamycin content for about $65 from Marek Health. The results: the lab report says < 0.5 ng/mL, which I take it means no measurable rapamycin.
Does anybody know if rapamycin would be absorbed if taken via suppository?
Google is your friend… FYI: and perhaps this would at least make your prostate live a long time 
Preparation and quality evaluation of rapamycin suppository
Objective: To prepare rapamycin suppository, and to evaluate its quality. Methods: Rapamycin was used as active ingredient, polyethylene glycol 2000 and polyethylene glycol 4000 were used as main substrates. The suppositories were made using hot melt process method, and the drug content, weight difference, melting time, drug release with time were evaluated. Results: Polyethylene glycol suppository with rapamycin appeared white and translucent. Good hardness could be maintained at room temperature. The drug content, weight variation and melting time limit matched the requirements for the suppository. More than 75% of the loaded drug in the suppositories was released at about 25 min in the medium. Conclusion: This preparation of rapamycin polyethylene glycol (PEG) suppository can reach the quality requirements of Chinese pharmacopoeia, and may be developed as a new formulation of rapamycin.
https://xb.wmu.edu.cn/EN/abstract/abstract91.shtml
and a patent on a rapamycin suppository:
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Thanks for posting what Mr. Google found! I wonder if it would work to not use PEG 2000 or PEG 4000 and just insert the cellulose capsule containing the rapamycin.
You might also use Transcutol to increase absorption… its great for that; I use it for rapamycin skin cream and toothpaste. You want something like PEG or Transcutol to improve absorption.
Transcutol has a number of different chemical names/identifiers. Here is a list:
- 2-(2-Ethoxyethoxy)ethanol: Ethoxydiglycol, 3,6-dioxa-1-octanol,
- DEGEE, diethylene glycol monoethyl ether,
- Carbitol,
- Carbitol Cellosolve,
- Transcutol,
- Dioxitol,
- Polysolv DE,
- Dowanal DE
Chemical Identifier: CAS Number 111-90-0
Examples of Where you can order / buy Transcutol from in the USA:
LotionCrafters: Transcutol / Ethoxydiglycol
Laballey.com : Transcutol / Diethylene Glycol Monoethyl Ether
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I tried the Purecaps product and got the same result that I got with Acid Armor: a blood test result of < 0.5 ng/mL Sirolimus (rapamycin). However, at that time I was taking a turmeric product (Meriva, turmeric phytosome), which might have skewed the result. Elsewhere on this site, I believe RapAdmin posted a paper showing that turmeric in the system causes the liver to detoxify or break down everolimus, which is similar to rapamycin. But I would have taken the Meriva at least 24 hours prior to taking rapamycin in a Purecaps capsule. The half-life of Meriva in the blood is reported on some websites as 7.5 hours. So I would have taken the rapamycin about 3.2 half-lives after taking Meriva, so the Meriva concentrations should have been only 11% as much as the peak concentration.
Can siroboon fit inside any of these?
David, welcome to the forums. Is this delivery method (rectum) something you have personal experience with, regarding rapamycin? Did you do any testing to see how well it worked?
I am aware from posts in this forum that siraboon does have good purity and presence of Rapamycin . However it seems from blood tests that oral doses do not give the desired results due to a sub standard enteric coating I can only assume . So given this , I think that PR may work . I don’t have access to rap blood tests , so is anyone able to do the honours with PR SIRABOON ? I have no special expertise or experience by the way apart from what was in the link I posted previously .
I already documented all my blood test with Siroboon 2mg tablets in another thread. Look for Siroboon Lab Blood Test Results
Yes many thanks for that thread Adrian , I was wondering if anyone could just administer siriboon PR and do some tests , as it might be way ahead with a crappy coating so to speak !
PR admin WIKIPEDIA article : any medicine can be given this way and bioavailability is always higher and quicker ::
lol, i do not want to that way lol. I use a separate enteric capsule to protect the pills. Cost like $15 for 200. I can easily put up to 3 pills into one.
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Fair enough . But from what I’ve read , bioavailability is possibly many fold more than even the enteric capsule route . So was just wondering if someone had done the blood work PR , so if people do want to use that route , they can optimise dose