The inhibition of CYP3A4 from GFJ can last up to 1-3 days even though from my self administration 2-3 hours after is the best. As for Ritonavir it is stated that it could last up to 5-7 days…
No side effects from Ritonavir as far as I can discern (from that one dose a day before rapa). Recall that it is not uncommon to use Ritonavir as a booster with various medications, such as in Paxlovid against SARS-CoV-2, i.e., quite a common medication. And yes, because Ritonavir irreversibly inhibits CYP3A, its effect on raising Rapa levels may be prolonged, another reason to consider longer dosing intervals.
i think I’ll go back to 2 weeks interval. easier to manage.