I take (based on, but not identical with, I think, what @DrFraser suggested in the past) 8oz (~256cc) GFJ 3 hrs prior to taking rapa, then 4 oz (~118cc) at the time of taking it. I also have an EVOO chaser (~2T). I dose every fortnight.
I have a ‘stash’ of about one yr left, ergo the GFJ. I keep them in the refrigerator.
How long does rapamycin as Sirolimus in pill form last? Is it unchanged and usable if 2 years old, 3 etc. Just want to know how much to try to stockpile if I can.
Hello Powe.
As long as kept cool and dry in a dark place - rapamycin seems to have a very, very long shelf-life. I am using zydus that is 3-years old, full potency when I check it through a LABCORP blood test. I am getting 3 ng/mL per 1 mg pill. Top effectiveness.
It’s long effectiveness was proven decades ago by Surendra Nath Sehgal - his rapamycin was at full potency after 5-years in a freezer.
Why Ketoconazole as opposed to simply using grapefruit juice, which should be safer and probably just as effective?
Yes it absolutely does matter. While 200 ml will increase bioavailability quite a lot in many people, to be more certain of getting a strong effect it’s advisable to take 300-400 ml. For some people, 200 ml will only have a small effect or even no effect at all! Note that taking more is very safe because there is only so much that you can inhibit the CYP3A4 enzyme. Once you reach close to maximal inhibition, more juice won’t increase the bioavailability any further.