Rapamycin breaks?

I’ve noticed that Matt Kaeberlein mentioning that he takes periodic rapamycin vacations / breaks as part of his regimen. Do you have regular breaks in your regimen? If so have you noticed anything about starting or stopping those breaks in terms of how it affects you?

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I’ve wondered if periodic breaks would be a good idea for testicular function.


How does Rapamycin affect the testes?

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See here for info on possible impact of rapamycin on testes Possible Rapamycin Risks for Healthy Humans (Part 2)

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Has there been any link between Rapamycin and cataracts in humans?

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From 2009

Sirolimus in the Treatment of Retinal Diseases


No, not reported as of now.