After 3 weeks my Oura ring scores for deep sleep and HRV have plummeted (lowest HRV scores in 4 years) , although the first week , I took 2 mg , and my deep sleep doubled. Then I went to 4 mg the 2nd and third week. One week was a 6 day week. That might have caused some trouble. This 4th dose will be after 9 days and I will take 6 mg. Hoping to get better HRV results then this past week. Hoping deep sleep improves. It it does not improve in the next two weeks I will go back to 2 mg. Also my sleep efficiency score has plummeted. Seems to be effecting my lungs and breathing. I now have mucus in my nose and in back of throat and I have not had any of that for over a year.
5 Likes
this is a great thread.
I came on here today to research Rapa and sleep. I’ve been sleep hacking for the last 10-12 years and have found that TCM is the only thing that keeps me asleep for more than an hour. Needless to say, I was nervous starting Rapa after reading this thread however I started a few weeks ago and have already a difference in my sleep pattern.
My normal sleep pattern has typically been getting a full 90 minute cycle and then waking every 2 hours, staying in bed for a full 9 hours every night.
First week I started with 1mg and sleep well the first night and by the 3rd or 4th night I was getting well over 3 hours each night thereafter. my next dosing, I increased to 2mg and after the 5th day, I woke up once and then slept for an additional 6 FULL hours straight. That literally hasn’t happened in 10 years.
Sleep has been my only health concern so I’m thrilled at my results so far!
7 Likes
Congratulations. I wonder when, during the day you take rapamycin?
Most people take it in the morning. But I have read that some in the community have experimented with taking it before going to bed.
4 Likes
Sounds like a mitochondria thing. The thing to understand about sleep is that we have sleep cycles which are the ultradian HPA cycles. If those are in parasympathetic state we can sleep. If in sympathetic state we are awake and that will last until the next cycle. (about 90 mins)
1 Like
I just shifted to before bed rapa dosing. I slept like a baby the first time. That’s my plan until it doesn’t work.
6 Likes
I have been dosing first thing in the morning on an empty stomach with krill oil.
1 Like
I actually prefer taking rapa at night as well. Someone here suggested not swallowing the pills until you are literally about to nod off so that’s what I’ve been doing and it works great for me even as a person with major sleep issues from decades of shift work.
9 Likes
Hey, know the last response was almost two years ago, but want to weight in. Seem to be the minority where rapamycin seems to improve my sleep the night I would take it.
I never have a problem falling asleep. I basically have the opposite problem - which is a family trait - sit still too long, and fall asleep. And with age, fall asleep “accidentally” on the couch most nights, before waking up, watching a time-shifted talk show, and going to bed for real.
I find that when I was taking rapa (branded Rapamune tablets) at night - 1 or 2 mg, but always with two glasses of fresh-squeezed grapefruit (so presume I was effectively taking 3 to 6 mg) - when I fell asleep it would invariably feel like a deeper sleep - much more likely to sleep though the night on couch, or if I did wake up to haul myself to bed, would always feel groggier, like waking up from a deeper sleep than normal.
I don’t think I ever noticed this effect past the first night. But then again, my overall dosage is low compared to many commenting on this topic (and in this forum in general).
1 Like
I am very foggy in the head the morning I wake after rapamycin at night… by noon I am firing on all pistons again.
Afterall, you did just convince every cell in your body you are in starvation mood.
Always need to warn staff first thing … it was my rapamycin night… just 
heads up.
3 Likes
Also on 6 mg/week with no noticeable effect on sleep.
I noted my sleep to improve when off Rapa
2 Likes
Mine is good with Rapa, score between 80 and 90. Deep sleep is 1 hour or more. Cannot complain.
1 Like
I take 7 mg rapamycin in a fasted state in the morning. My HRv drops the night after rapa and sleep qualty is lower.