whats your sleep schedule like already?
First 3 times I took rapamycin ( 2, 4 and 4mg) I took it in the morning because I had read that rapamycin could cause insomnia but it made me very tired and sleepy for the first half of the day but today I took 6mg and hardly notice anything…
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I’ve read through your post of various supplements for sleep, including the current 3 mg melatonin + 2 mg tryptophan. It’s very interesting. Are you not plagued with BPH symptoms that wake you up to go to the bathroom? Or, is it that you may have had symptoms at one time, but they have gone away?
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I have been taking Flomax for years. About 20 years ago I had laser prostate surgery and have been good ever since. Whatever I have been doing, because I have taken a lot of different supplements over the years, none prostate-specific, has slowed age-related BPH and my flow is near normal.
Before taking rapamycin I was struggling to get a good night’s sleep, but I don’t think it had anything to do with BPH, but with old age.
I have to say it took almost eight months of rapamycin to produce results. Now I sleep 7+ hours without waking to go to the bathroom. I wasn’t taking rapamycin for this, but I am pleasantly surprised by this result.
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Please tell me the brand of tryptophan you use. Thanks.
NOW Supplements, L-Tryptophan 1,000 mg from Amazon.
How are you doing? After about 7 months of relatively high dosing my sleep starting improving rapidly by the end of 8 months I was sleeping like I did in my 20’s. Now I only take 3 mg of melatonin for other reasons than sleep and I am getting a solid 7 -8 hours of good sleep at night. And even better than in my 20’s, I don’t wake up groggy and feel the need to have that first cup of coffee right away. Now if I get even slightly distracted I won’t have that first cup of coffee until two or three hours after I get up. And, I love coffee.
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I just took my first 1 mg dose (in a early morning fasted state with oil in bulletproof coffee) and it definity had a negative effect on sleep, cutting down on total hours as measured by FitBit, as well as “sleep score” and also how I felt.
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Could be just in your mind. 1 mg dose can hardly contribute to that.
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Agreed. Unlikely that 1 dose of 1mg has any discernible effect.
I take 6mg weekly or 2g/wk if I eat a whole grapefruit with the dose. Either way, my sleep is very poor and fragmented for 2-3 days after the rapamune.
Despite the low dose you took, I think it possible the rapamycin impacted your sleep. I had similar sleep quality issues to yours when starting with 3 mg of compounded rapamycin. Given that it was compounded rapamycin, it is possible it was equivalent to 1 mg of the enteric coated tablets.
I personally find sleep disturbance and psychotropic impact to be the main symptoms from taking rapamycin. I find myself at 67 to be in good physical health by most metrics. I would say though my sleep in general has declined more than my general health which has remained stable. I think that could be because of the aging related decline in circadian rhythm. I would also factor seasonal daylight changes for those of us living in the northern hemispheres.
A search in PubMed or PsycInfo or Google Scholar comes up with a number of articles on mtor inhibition and circadian rhythm etc. I suppose whether 1mg is enough to impact mtor inhibition is the crux here. But in my case I think even the low dose of rapa impacted my sleep.
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For people who experience sleep disruption from rapamycin, it would be interesting to all of us if you could post about the experience over time.
- Does it happen at a certain dose level?
- Does it happen even if you take the rapamycin in the morning?
- Does it’s impact change over time - does your body adjust and does it stop interrupting your sleep after a certain amount of time?
- Are your sleep disruptions associated with rapamycin confirmed with data from a sleep monitor, or are you just providing a subjective measure?
I have taken rapamycin the afternoon or evening once or twice and could not sleep at all during the night - just was not tired. When I take it in the morning, I’ve never had any issues (at any dosing level). After one or two experiences of sleeplessness, I’ve stayed on the morning dosing schedule so have not run into it again.
Generally I find now my sleep is much deeper and better since taking rapamycin. At least subjectively. I don’t have a good sleep monitor to validate with data.
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I take 6mg weekly with Metformin in the morning and my sleep is much better than usual. No wake ups and works perfectly when I am traveling overseas too.
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As I have posted before: After several months of taking rapamycin at levels of 5 - 20 mg weekly and bi-weekly, my uninterrupted sleep time greatly improved and I have eliminated most things from my sleep stack. I always take rapamycin before noon and haven’t noticed any effect on my sleep on the days I take rapamycin.
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It very well could be the bag of peanuts conundrum. Have everyone in the world eat a bag of peanuts and you get very different results based on their biology.
For one person, Rapamycin may help sleep and for another, it may disrupt it.
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Could be, Fitbit sleep score went from 83 to 74. Back up to 82 two days later.
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Vitamin D definitely helps for sleep.
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Welcome to the forum, Elea. It’s good to see that Rapamycin is providing you with positive effects! Here’s to your good health!!!
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Melatonin and Glycine 1 h before bed helps me much. I fall asleep almost immediately. If I wake up at night, I take another Glycine and fall back to sleep. Also sauna is worth trying.
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