@mike666 Yes, my approach to preventing and treating ED definitely involves “all the things.”
I have two clinics, which is confusing, but in the stem cell/regenerative medicine clinic we’re doing procedures mostly. That’s the clinic I spend most of my time (Docere clinic).
In my other office (Biorestoration), we focus on everything else - lifestyle, hormones, nutritional supplements, low intensity shockwave therapy. I have excellent practitioners who see patients there, but I’m mostly an owner/advisor at this point. I’ve recommended the providers there consider adding Rapamycin to the offerings. We’re still in discussions.
Your vegitarian diet should contain enough nitrates, but watch his videos.
There’s anti-aging reasons to be taking PDE blockers daily anyway, IE cialias, 2.5mg to 5mg / daily
Its under appreciated the health benefits of boosting NOx.
@AmyK, please please don’t underestimate the negatives and many (many) side effects of oxalate poisoning. Oxalates are in most of what you are eating being vegan. Theres alot of disinfornation or willful ignorance of the anti-nutrients in plants. Not swaying anyone just our study of N=2, but our 20yr journey has us both being carnivore due to our problems with the anti-nutrients in plants including oxalates but including the many many others.
The gut microbes that denature oxalates come and go and with gut-dis-health you may be storing alot of oxalates.
@curt504 Thank you. I’m friends with Nathan Bryan - we have spoken on many of the same events over the years and I talk a lot about nitric oxide in all of my presentations about ED. And, yes, I’m a big fan of PDE5i’s for ED but also for keeping the cells in the penis healthy (as well as many other tissues in the body). Rapamycin is much newer in the sexual health space though and I’m excited to see what, if any, benefits it offers over the other therapies I use in my office.
@Amyk, WOW impressive reply. Amazing who posts here. Comparing google results from
rapa + ed vs spermadine + ed vs shockwave + ed, actually decent search results from rapa and shockwave (no surprise) and some for spermadine.
BUT per my own experience with both, rapa+spermadine (high dose, 10mg maybe hhigher, via Hansen the swedish/norwegin quality supplier of many nutricals) do not compare in efficacy to PDE5 blockers, 10:1 or higher (N=1), where what ever the effect of rapa, senolytics, spermadine must be very low level (for me).
If I where a practicioner offer help to patients, given the costs and logistics of taking rapa and costs of spermadine, I’d not (if I where a practicioner) reco either for ED. My enlightened personal practitioner but not anti-aging gives me a 2.5mg cialias prescription. I find I need to augment with 5mg or more now and then throjgh the week. Just IMHO nothing is removing the 10mg cialis pills from the std ED protocol. I would add though, Bryans NOx protocol of avoiding antiseptic mouthwash/tooth pastes and take an exogenious source of Nitrate. Forget food sources due to the many anti nutrients in plants that the aging body can’t denature as we age.
Side comment; and jjust N=2, as we age we need to trend toward lower anti nutrient foods, which for us is buying grass fed meats driect from quality (Albrecht soil science) farmers (1000 hills in MN, a few PA amish). Also mentioning; as we age our protein needs go up to prevent sarcopenia (with or without excersize). My ability to eat volumn has gone down forcing me to use quality protein shake in AM and carnivor for rest of protein needs + a bucket of nutricals for the rest (probably mainly expensive pee but … tbd).
Please folks I would NOT reduce food/calorie intake on the basis of life extention at the expense of nutrition.
I just got my first prescription of Tadalafil. 2.5 mg daily. Oddly, I think my interest was piqued by an MB post in an AmyK thread on Twitter. No ED issues so far but I’m certainly of an age. It does seem like a nice counter to rapamycin.
Have you tried pine bark extract as a NO booster. I’ve had success in patients trying this, especially in those who experience side effects from the meds.
The difficulty is that it’s not one size( dose) fits all. The effective dose can range from 100mg to 600 mg per day depending on the patient. Some also benefit from adding L arginine.
The other benefit from boosting NO with the combination of pine bark with gotu kola is arresting the development of atherosclerosis.
Adding a bit of NO info on this thread; I found this NO researcher Dr Nathan Bryan, has lots of youtubes. Summarizing from Bryan;
Increasing NO via the arginine pathway slightly works
Better pathway is via consuming nitrates; conventional leafy greens (organic has very little nitrates LOL). Including beets, beet juice.
BUT food based nitrate sources brings an unwanted anti-nutrient; oxalates (very bad).
So take a synthytic nitrate source to avoid oxalates. Many on amazon and Dr Bryans website.
BUT a KEY; you can’t be killing the bacteria in your mouth that makes NO from nitrates in your saliva. Stop anticeptic mouth washes and flouride tooth pastes (do this also to reduce flouride intake).
I also take 2.5mg tadafile/day. Bryan offered case studies of tadafile non-responders getting fixed with stopping mouth washes and upping nitrates… Not mentioned here is over arching health issues of; metabolic health, weight etc.
Its worth watching a few Dr Bryan’s youtubes to understand the range of benefits of having sufficient NO. Theres a saliva test strips on Amazon. Benefits range from; O2 update, immune function, aiding keeping the arteries free of plaque, managing blood pressure…
Yes! I’m a big fan of Nathans and I recommend his NO2U lozenges to my patients. Medications like Viagra don’t work if you don’t make your own nitric oxide (and is one of the reasons those meds stop working for some men) so making sure to get/make enough NO is important for sexual health (and general health!).
Thanks Amy - Never realized I needed this boost. Just orderd Neo40 by humann.com A bit pricey at $78 for 60 pills ( 2 a day for first month, 1 a day after). Medical Doctor recommended for Nitric Oxide improvement - 5 star rating. Good for blood pressure and sexual function. Nice!