What is a low dose of rosuvastatin?
I’m starting 5 mg/day right now, will test my apoB and check for any side effects.
What side effects should I look for?
For people with hypercholestoremia, 5 mg rosuvastatin should decrease apoB by -38% and LDL by -45%,
“It is essential to point out that studies had heterogeneous designs and scientific quality of studies was quite limited”
Maybe, I am just a non-responder.
Consider trying a higher dose for longer time.
There is no cognitive side effects there.
Most serious seems to be rhabdo. Something that’s possible to get by exercising a lot too.
Other then that… muscle pains?
I already tried Lipitor and Atorvastatin - same side effects. I can try to take Rosuvastatin 2-3 times a week vs daily and see if it helps.
I shifted rosuvastatin 5mg/day to 10mg every other day to avoid feeling hard fatigue after my weight lifting. My apob increased a couple points (65-67), so it was a good trade.
Vince G. is absolutely right in his crusade against chronic inflammation and it’s link to all things aging and age related diseases.
Chronic inflammation and the hallmarks of aging - ScienceDirect
We should investigate all things anti-inflammatory that are both safe and effective and come up with the top 10.
I think this would be a useful list and discussion. Of course all the normal lifestyle interventions would have the biggest impacts but I assume the question is “what else?”
If chronic inflammation is an immune system issue, then the biggest impacts would come from improving the gut? Solving leaky gut, increasing SCFA, building a more resilient gut microbiome, avoiding antibiotics, phytonutrient targets? Am I wrong?
I already added turmeric, ashwagandha, Boswellia and ginger to my supplements. Also mixed boswellia oil with my body lotion for joint support. Turmeric root is delicious with cooked barley or rice. Shredded ginger is great with lemon tea or lemonade.
Curcumin (in Turmeric) and Gingerone (in Ginger) are both HDAC inhibitors. Helps with gene expression.
Would be taking 10mg rosuvastatin and 10mg ezetimibe daily be sufficient to keep your cholesterol levels down on a moderate dose of rapamycin (3-4mg with fat per week)?
Yeah, tweaking lifestyle for you and I would probably have minor effects at this point. For someone at baseline unhealthy, minor adjustments can have major effects.
The gut of course is important and fiber seems key. Gut diversity appears more important than any single organism. Fiber would be on the list for the gut effects.
It’s difficult to find high levels of the gingerol component. It was interesting that a study showed reduction of ovarian cancer with ginger, but only the powdered form.
Check out palmitoylethanolamide. Cloves are very potent.
I find HDACi an interesting area. I am trying to do some exhaustive reading up to find as many of the natural HDACi molecules that have been found. There are quite a few papers that look at this, but often they have different subsets.
That’s a solid dose but I only know one way to find out for certain.
As many forum member do not know;
These tend to concentrate on HDACi that operate in the nanomolar range. I tend to look at the natural molecules which tend to be more in the micromolar range (and some in the millimolar range).
My fab four are Curcumin, Berberine, Pterostilbene and Quercetin.
However, I am working on identifying a further set which I can add to.
What I like about these sorts of molecules is that they have been around for a long time and used for medicinal purposes. Hence we know if there are any issues with chronic usage or even large volume usage.
This is why I think they matter
Interesting. Do you have links to any studies that indicate that low LDL may be associated with problems with immunity or that it leads to suboptimal activation of TLRs? I have researched low LDL quite a bit and didn’t find any evidence of it being harmful for immunity or really for anything else.