I think that he’s just going by the animal studies - the best lifespan improvements have been achieved in early adult age mice and high (highest) doses of rapamycin.
The risk of negative reproduction effects seem low to me (given that organ transplant recipients have been using rapamycin for decades while also having children) - but it would be wise to try to track this in your own case. If I were you, I’d read all the studies related to this - and see if there are some good tests that you can take that would help you track your fertility and identify any impacts. Most of us here have already had children - so are much less concerned about this possible issue.
It would be great if you could do some research on this and identify possible tests that could be done (I wonder if places that take sperm donor submissions do any sperm motility tests, etc. - that may be valuable in identifying any possible negative effects of rapamycin. Perhaps do the testing while taking rapamycin, and also during the pauses … to see (as we would expect) if any negative impact then reverses when you pause rapamycin.
Each candidate provides a semen sample for analysis.
We assess sperm count, volume, motility, and additional factors to determine the quality of the donation.
Perhaps get this done regularly while taking rapamycin to see if there is any impact?
Personally, I liked how starting at 1mg / week, and then slowly increasing by 1mg per week until I got up to 5mg… then stayed their for a month, then increased to 6mg.
I hear some people report negative side effects and it seems to correlate a bit to ramping up faster. This is just all anecdotal of course. We don’t have good data really on this area.
SO I am thinking of participating in this study to get biomarkers done but also to see how my body responds to challenges.
Would be interested to see if rapamycin impacts any of these responses
Also in terms of rapamycin taking, should I wait until I am in a cardiovascular block of training to take it, or is it okay to take when I am in a muscle building phase?
Yes - I love clinical trials like these were we can get extensive test information on our body - great find!
Regarding exercise cardio / vs. muscle and rapamycin - the research is unclear. Here is what one of the top rapamycin researchers had to say on the general topic (not specifically to your question but close):
Another thing I need to figure out is how long I want to be on rapamycin before being off of it since I just am curious in the event it improves my biomarkers, how long those effects last. I also need to reach the rapamycin dosage that most see benefits without any side effects.
Yes - those issues are what we all face - and even harder I think for you because at your age everything is functioning extremely well (I would hope ;-). I think regular blood tests (monthly or very few months) would help you get a good handle on these issues.
Another cool thing about the trial is that they are doing a DEXA scan before hand and will give me the results that day. The unfortunate part is that the blood biomarkers wont be viewable until the study is published.
I am with Blagosklonny on this. I have NO IDEA if Rapamycin will extend my healthspan/lifespan, but I’m not soley banking on it. The only proven lifestyle intervention that categorically increases human lifespan is cardiorespiratory fitness. Being in the very highest percentile of V02 max easily adds 5-7 yrs to lifespan. I do daily intense cardio/resistance training 7 days/week, including Rapamycin dosing days. I have not noticed any impact on my exercise during/post. Being super fit, lean (adipose tissue is inflammatory), muscular, with superior cardio respiratory fitness is my #1 lifestyle intervention. Rapamycin, strict keto (plant fat based), one meal day time restricted feeding, exogenous testosterone, basket of supplements, every 8 week phlebotomy (Iron dumping, huge longevity basket opportunity IMHO) these are all add-ons. Having elevated ketones area under the curve (inversely lowest glucose/insulin) is its own huge longevity signal…ancestrally preserved (a thread unto itself). I have never looked or felt better in my life (57 yo male).
So I just did my blood work, and I was wondering
I have high Cholesterol , LDL and non HDL cholesterol,
Do you have any advice on lowering these values? and does rapamycin help with them?
My understanding is that atorvastatin is the best statin out there - and I’ve taken it in the past, and may again in the near future - but I’m not a medical professional, so take that with a grain of salt.
I’m new to PKS9 inhibitors - still doing research, can’t help you on those.
Okay, is there any other advice you would have for lowering these levels. I mean they were really high , which is weird because I eat relatively healthy and fast/exercise a lot.
Any good diet recommendations or anything else I should try to look into?
You could also consider Ezetimibe, I take 10 mg rosuvastatine / 10 mg ezetimibe 2 times per week and my total cholesterol dropped with 40%. This is good info;
How does rapamycin impact those values at low to moderate doses? I noticed a lot of the literature showed some increase at high doses. Have you had your values tested before when you were on low doses?
I found this article which was interesting