I didnt intiate this dialogue about corruption. I posted about stem cells
thanks Jay, I am going to look into this further Problem is that this is for my wife suffering from dementia. I can see where she may not ingest the fluid quickly enough to bypass the “bluing” affect. I may fall back to putting it in a capsule, but problem is THERE she chews ALL of her supplements before ingesting…kinda funny habit, but its ok with me. there is research that indicates that “chewing” something actually is better for the efficacy of digestion anyway (although chewing up the fish oil pills cant be pleasant—but she’s atrooper). sooooo I thought by totally diluting the “blue” in 12 oz of trying to figure it out.
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BajaBrent, Try it yourself to see what you think. An ounce or two goes down fast and methylene blue has no taste. I did it before coffee. Then, I had breakfast and brushed my teeth. I didn’t notice any mouth blueing after that. One more note is that my reading indicated to start with one or two drops for a few days, then 3 or 4 drops for a few days and so on until you get to 20 drops (10 mg). The point seems to be to look for any type of effect. As I said, I noticed nothing, but plan to try again in a few weeks. This appears to be a safe low-dose amount and may have a gradual impact on improving mitochondrial function, especially in the brain. I believe this is what Dr. Gonzalez-Lima is seeking in his clinical trial (last link below).
The information I’ve read connects methylene blue with possible improvements in Alzheimer’s which is not your wife’s problem. But, that doesn’t mean that it would be of no benefit. I suppose it’s just a matter of research, possibly followed by a low-dose trial. Here are some articles you may have already read. Again, they’re specifically connected with Alzheimer’s, but there may be something useful anyway. The first one is general information about potentially useful supplements for cognition. The last one I included because it gives timelines and dosages, I think. Otherwise, the last link has nothing useful.
Sure - there is unquestionably corruption in every country of the world at some level.
I guess all I’m saying is that I trust that the people providing the medical procedures (doctors, nurses and the professional oversight groups) and the manufacturing and quality control systems for the medicines and biologics in the US / Canada, Japan and Western European countries more than in countries that have fewer years experience in these areas.
I’m much more familiar with the example of India and the manufacturing of generic medicines because I’ve read the book by Kathleen Eban about the Indian Generics industry and the corruption in that industry Why and How to Test Your Rapamycin for Purity, Dosage and Contaminants
And, I’ve worked closely with many companies in China - both on the tech engineering and manufacturing side and chemicals side, and in other areas of business, so I know the daily levels of corruption in that country also, and the issues are well documented in the nutritional supplements market. See this post and related links: Buy Rapamycin Online - List of Reliable Pharmacies - #63 by RapAdmin
But - I suspect that the issue is the same in all countries outside the top 10 or 15 developed countries providing medical services and medications or biologics. I’m not singling out Mexico - I suspect the issue is equally true in many other countries (I use the corruption index as a simple way to identify the “riskier” countries).
I’m sure there are many situations where you have excellent medical services and medications/biologics in these countries - but given the difficulty of evaluating the quality of medical services and medications - I default to less risky. I just believe the distribution curve of the quality is much flatter (more standard deviations of variance from the mean).
My belief is that as a biohacker / early adopter, I’m already taking risks that most people would not take, so I don’t want to take unnecessary risks when it comes to medical services or medications (I would not have purchased medications from India without seeing lab test results (see here: Sirolimus Lab Test Results), and talking with experts who do the lab tests frequently on Indian medications).
Everyone is welcome to take whatever risks they want with their health. I tend to avoid getting healthcare products and services countries that don’t rate well on this list (unless I can get them evaluated by independent third parties):
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‘I tend to avoid getting healthcare products and services countries that don’t rate well on this list (unless I can get them evaluated by independent third parties):’
So to continue off-topic, I’ll put in a good word for Tijuana dentistry. I’ll even recommend a specific dentist: https://advancedsmilesdentistry.com/
I’ve had two implants done there. Not every procedure they do saves all that much, but the implants saved about $2,000 each. And they’re not made of wood. Ask a local dentist if Straumann implants are a good choice.
Everyone speaks excellent English. It’s about $10 parking at the border, and another $10 round-trip to the office by Uber. Of course living in San Diego makes this a lot easier.
I recently had an extraction done. My regular US dentist can’t cut, and he thought that might be necessary, so he referred me to someone locally. Their estimate: $1600 (after insurance). Including $600 for sedation. I assume they were rolling the dice to see if they had a live one on the hook. I had the extraction done at Advanced Smiles for $150. Net $45 after insurance.
Replacing a six-unit bridge that is my lower front teeth there on Monday. Exciting!
Hundreds of reviews on Yelp for Tijuana dentists. Leave it to you to decide if they’re phony or not.
I don’t disagree that there can be some great deals via medical tourism, i would just do a lot more Validation and research.
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I’m surprised no one has ever posted this 2023 paper: Reduced Prevalence of Dementia in Patients Prescribed Tacrolimus, Sirolimus, or Cyclosporine
All drugs examined reduced dementia prevalence compared to the general population-like control.
Converging mechanisms of action between tacrolimus and sirolimus likely explain the similar dementia prevalence between the cohorts. Calcineurin inhibition within the brain has a greater probability of reducing dementia relative to peripherally-restricted calcineurin inhibition. Overall, immunosuppressants provide a promising therapeutic avenue for dementia, with emphasis on the brain-penetrant CNI tacrolimus.
However, some argue that immunosuppressants may prevent AD (and other NDDs) but that post-diagnosis, they might aggravate the condition: Rapamycin and Alzheimer disease: a double-edged sword? 2019
We’ll soon know the results of this phase 2 trial anyway: Rapamycin - Effects on Alzheimer’s and Cognitive Health (REACH)
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