I just had labs and my cholesterol readings went up some since I started Rapamycin. Has anyone had a similar experience?
Ah - ok, you’re going to make me go back and look at my old blood tests … but, probably something I need to track anyway. I think my cholesterol levels are up a bit, but my ratios are good. Let me dig up the past year or two results, throw things into a spread sheet and get back to you…
Thanks for the extra effort. Just FYI. Here is my data:
total Cholesterol went from to 122 to 154 (100-199)
Triglycerides went from 48 to 65 (0-149)
HDL went from to 45 to 53 (>39)
LDL Chol Cal went from 58 to 88 (0-99)
VLDL Chol Cal went from 11 to 13 (5-40)
My diet is more strict than ever so can only figure it is due to rapamycin.
Here are my last two blood test results - mine have always been on the high side, even if I have a great diet (much of the past 20 years I’ve been mostly vegetarian and fish) but always a higher cholesterol level… so I’m not sure if this has changed at all on rapamycin. I used to take statins, and have for much of the past 10 years. Will revisit the issue next appointment.
I’m on a higher dose or rapa this Fall quarter - 10mg/week, vs around 7mg/week back in Feb. 2021. So rapamycin might increase cholesterol levels.
February 2021 blood test results:
September 2021 Blood Test results:
Yes, I have as well and I’m also on a statin (10mg crestor). My cholesterol appears to be uncontrolled with diet as I spent 2 years trying to fix it with a mix of vegetarian and pescatarian diets. Before a statin, my Trigycerides were 210.
This is after 6mo of 6-8mg a week Rapamycin
Total Cholesterol 132>135
All my particle numbers went up as well
and ApoB went from 62>67
Interestingly my LP PLA2 numbers (essentially a measure of arterial inflammation) went way down from 103>76
There is clear evidence that immunosuppresants can increase lipids, particulalry TG, dramatically. See: Medication Induced Changes in Lipid and Lipoproteins - Endotext - NCBI Bookshelf
perhaps this is why Alan Green and Mikhail Blagoskionny both take and recommend a statin and ACE2 inhibitor as part of the protocol.