@Agetron you still doing Doxycycline 200mg with your Rapa dose 100 day and 100 night or all together? I am going to do this too since I now have a bionic hip. Figure it should negate the risks of rogue bacteria inhabiting my prosthesis.
1 Like
Changes in Gut Microbiota Induced by Doxycycline …
by I Robles-Vera · 2021 · Cited by 6 — Doxycycline Treatment Improved Intestinal Integrity, Colonic Inflammation and Reduced Endotoxemia and Plasma Noradrenaline in DOCA-Salt Rats.
1 Like
Yes, I still take 200 mg on the day of my rapamycin dose.Yes, a 100 mg pill in morning and 100 mg at bedtime.
Pretty healthy… skin heals rapidly when injured. Open cut to gone in 5-7 days.
If you at this subclinical dose can see an increase in doxy-resistant bacteria and a decrease in friendly bífidus bacteria, I think it bodes bad for chronicle use at therapeutic dosage. It’s prescribed for youngster with severe Acne, but I don’t see it as proof for that it’s without side effects. Maximal treatment length against acne should be 3-4 months because the risk of developing resistente bacteria.
Doctors are probably prescribing doxy quite frivolously, because there already are a lot of of resistant bacteria circulating, knowing that they have heavier (as still effective broad spectrum) weapons in their arsenal.
I for sure know that i won’t volunteer to become a vessel for growing these resistente bacteria in my gut.
But each to their own. 
4 Likes
I have been on the 6mg Rapa plus 100mg Doxcycline regime for about 4 months (almost immediately once I learnt about this).
The reason I was so quick to jump on this was twofold (I also have MS):
Synopsis: Addition of doxycycline to interferon-beta therapy in patients with relapsing-remitting multiple sclerosis might improve control of inflammatory lesions.
The rapamycin + doxycycline combination decreased tumour proliferation in about 2/3rd of the investigated cell lines. The continuous treatment reduced tumour growth significantly both in vivo and in vitro.
6 Likes
I should have thought of this sooner. About a third of my femur plus my entire knee are mostly stainless steel (I had chondrosarcoma) and a big concern is infection which - if it gets to the implant - is Very Bad.
Thanks for the insight!
2 Likes
Affordable Rifaximin/Rapamycin, Rybelsus,SIBO Discussions
Point by point analysis by Richard.
3 Likes
It sounds like he’s dropped the doxycycline he was taking with rapamycin.
I also found this interesting:
And his current protocol:
Longevity Practices_27Nov23.pdf (658.2 KB)
7 Likes
It makes me wonder if a alternating schedule on a twice weekly dosing regimen could mitigate the potential for problems. My thought was 50 mg twice a week for Doxy, but I don’t know minocycline well enough to know the dosing. Also, how hard is it to get minocycline? It’s not likely the traditional medical system would be willing to prescribe it. I wonder if it’s available from international sources? I see that it’s cheaper through a veterinary sources by a factor of 10!
1 Like
Minocycline is commonly prescribed in the US, I write scripts for teens with bad acne who get stomach upset with doxycycline. It has neuroprotective features and decreases inflammation in the central nervous system. Super inexpensive especially if you use Amazon medical and pharmacy.
Just be careful with long term use of minocycline because unlike doxy, mino can cause a permanent blue/gray discoloration of the teeth and gums. It can also cause dark navy-blue patches in the skin. I’ve seen this a number of times over the years, usually patients who come to derm in a panic and have been on minocycline for years, prescribed by a provider who didn’t know any better. This is almost never seen with short term use but gets more common the longer it is taken.
4 Likes
I have taken it BID for years, and acne, still at 64, but I believe you, just have not experienced it pesonally.
1 Like
Wow you are fortunate. At least you’ll know what it is immediately if it ever happens. It can be reversible after cessation of minocycline in some cases, but not always.
1 Like