Long-term use of antibiotics can cause liver and kidney toxicity and may lead to autoimmune diseases. Many people who have taken doxycycline or minocycline for an extended period of time have developed autoimmune liver diseases. It should be noted that those who have this disease cannot expect to live a long life.
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For some reason this seems very interesting to me.
It is precisely because the current view is that the gut bacteria is very important.
This is a very contrarian intervention. Surely Peter Diamandis is familiar with the gut microbiome talk and trend. And he takes it despite it. Talk about going against the grain.
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I’ve heard it’s common in China to take antibiotics (like in a drop-in clinic with IV), for overall wellness, is this true? Not saying it’s bad or good, just curious.
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It’s possible that at this low dose weekly it improves the microbiome and reduces the microbial burden. It could act as a selective herbicide does for the farmer, to hurt the bad guys and make it a little easier for the good.
I’m not an expert at this, but it’s not the craziest thing I’ve seen. Farmers (whether right or wrong) have for years fed tetracycline because it makes the animals healthier and makes money. I don’t know if they still do, I’m not in that business any more.
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https://www.costco.com/cmpps?drugIdentifierParam=55698435705&drugNameParam=Doxycycline+Hyclate
Doxycycline, 20 mg, 60 tabs, $18.99.
Four studies reported on the effect of doxycycline on faecal microbiota, one at suboptimal dosage (20 mg for 9 months) in patients with periodontitis57 and two at usual dose 100–150 mg for 7–10 days, although one also with a probiotic,56 58 and another at low dose (40 mg for 16 weeks),59 as described in table 2. Doxycycline treatment did not significantly affect counts of total anaerobic bacteria, candida, total enterics, Staphylococcus or doxycycline-resistant bacteria recovered at any of the sample periods and did not result in the development of multi-antibiotic resistance.57 Matto et al 58 specifically evaluated the influence of doxycycline therapy on the composition and antibiotic susceptibility of intestinal Bifidobacteria in nine subjects while they were also taking a probiotic and compared these to adults consuming only probiotics. A marked decrease in diversity of Bifidobacterium populations was observed during doxycycline therapy. Tetracycline-resistant Bifidobacterium isolates were more commonly detected in the antibiotic group than in the control group, thus increasing the pool of resistant commensal bacteria in the intestine.
In summary, doxycycline interferes with a microorganism’s ability to manufacture proteins. At suboptimal dosage (20 mg per day), it has little effect on the gut microbiota with the exception of enterococci and E. coli .
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Yes, at 20mg it seems to be an AINO (Antibiotic In Name Only) and would seem to be safe even long-term.
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@Agetron you still doing Doxycycline 200mg with your Rapa dose 100 day and 100 night or all together? I am going to do this too since I now have a bionic hip. Figure it should negate the risks of rogue bacteria inhabiting my prosthesis.
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Changes in Gut Microbiota Induced by Doxycycline …
by I Robles-Vera · 2021 · Cited by 6 — Doxycycline Treatment Improved Intestinal Integrity, Colonic Inflammation and Reduced Endotoxemia and Plasma Noradrenaline in DOCA-Salt Rats.
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Yes, I still take 200 mg on the day of my rapamycin dose.Yes, a 100 mg pill in morning and 100 mg at bedtime.
Pretty healthy… skin heals rapidly when injured. Open cut to gone in 5-7 days.
If you at this subclinical dose can see an increase in doxy-resistant bacteria and a decrease in friendly bífidus bacteria, I think it bodes bad for chronicle use at therapeutic dosage. It’s prescribed for youngster with severe Acne, but I don’t see it as proof for that it’s without side effects. Maximal treatment length against acne should be 3-4 months because the risk of developing resistente bacteria.
Doctors are probably prescribing doxy quite frivolously, because there already are a lot of of resistant bacteria circulating, knowing that they have heavier (as still effective broad spectrum) weapons in their arsenal.
I for sure know that i won’t volunteer to become a vessel for growing these resistente bacteria in my gut.
But each to their own. 
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I have been on the 6mg Rapa plus 100mg Doxcycline regime for about 4 months (almost immediately once I learnt about this).
The reason I was so quick to jump on this was twofold (I also have MS):
Synopsis: Addition of doxycycline to interferon-beta therapy in patients with relapsing-remitting multiple sclerosis might improve control of inflammatory lesions.
The rapamycin + doxycycline combination decreased tumour proliferation in about 2/3rd of the investigated cell lines. The continuous treatment reduced tumour growth significantly both in vivo and in vitro.
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I should have thought of this sooner. About a third of my femur plus my entire knee are mostly stainless steel (I had chondrosarcoma) and a big concern is infection which - if it gets to the implant - is Very Bad.
Thanks for the insight!
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Affordable Rifaximin/Rapamycin, Rybelsus,SIBO Discussions
Point by point analysis by Richard.
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It sounds like he’s dropped the doxycycline he was taking with rapamycin.
I also found this interesting:
And his current protocol:
Longevity Practices_27Nov23.pdf (658.2 KB)
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It makes me wonder if a alternating schedule on a twice weekly dosing regimen could mitigate the potential for problems. My thought was 50 mg twice a week for Doxy, but I don’t know minocycline well enough to know the dosing. Also, how hard is it to get minocycline? It’s not likely the traditional medical system would be willing to prescribe it. I wonder if it’s available from international sources? I see that it’s cheaper through a veterinary sources by a factor of 10!
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Minocycline is commonly prescribed in the US, I write scripts for teens with bad acne who get stomach upset with doxycycline. It has neuroprotective features and decreases inflammation in the central nervous system. Super inexpensive especially if you use Amazon medical and pharmacy.
Just be careful with long term use of minocycline because unlike doxy, mino can cause a permanent blue/gray discoloration of the teeth and gums. It can also cause dark navy-blue patches in the skin. I’ve seen this a number of times over the years, usually patients who come to derm in a panic and have been on minocycline for years, prescribed by a provider who didn’t know any better. This is almost never seen with short term use but gets more common the longer it is taken.
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I have taken it BID for years, and acne, still at 64, but I believe you, just have not experienced it pesonally.
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Wow you are fortunate. At least you’ll know what it is immediately if it ever happens. It can be reversible after cessation of minocycline in some cases, but not always.
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