He’s saying 70-80% is placebo, I’d say make that more like 99% LOL. I injected everything under the sun, and I had zero, (and when I say zero, I do mean zero) benefits from any peptide other than GLP1’s which are great for losing weight, but I lost a lot of muscle on them also, so don’t know what to make of them. I don’t care who says what I will NEVER for as long as I live look at another peptide again. Total scam. Well, it’s a Russian invention so no wonder LOL.
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Sorry to hear that. Have you noticed any relief of symptoms or at least a slowing of progression?
As I have previously posted more than once: When I started rapamycin, I was having a hard time walking without a cane. I had a painful right knee and pain in my neck. I found relief after taking weekly high doses of rapamycin for a few months. I am now pain-free. Maybe a coincidence, but I have been able to maintain this for several years.
“Arthritis has a significant heritable component, but you do not inherit the condition itself—instead, you inherit a genetic predisposition that increases your risk. Because “arthritis” is an umbrella term for more than 100 different joint conditions, the exact heritability and genetic patterns vary drastically depending on the specific type.”
Other than your hands, do you experience any arthritic pains?
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“I don’t care who says what I will NEVER for as long as I live look at another small molecule again. Total scam.”
Extremely broad statements like this don’t accomplish nothing.
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I hear you but IMO peptides are scams unless FDA approved for certain medical conditions. And other than GLP1, there’s very few peptides approved by FDA. again, this is my experience and after I tried all the common once and had no effect whatsoever. Anything I take (other than peptides) has an effect, i.e. even aspirin I can tell it having an effect however small (less inflammation), peptides NONE, nothing.
Peptides, with the hep of physical therapy, have helped me resolve a herniated disk, a debilitating shoulder injury, and other assorted ailments that accumulate with age. Placebo or not, physical or psychological, thankfully they work for me. There are strong responders and non-responders to all kinds of exercises and meds. I may be an anomaly, but peptides keep me running at age 78, even with bone-on bone in my knees.
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I doubt peptides (or anything else for that matter) would be able to help with bone on bone (if I understand correctly what bone on bone is). other than a knee replacement procedure. And, no it is not the peptide not even the placebo effect that has helped you. It’s rather human body adjusting/self-healing that has alleviated some of your symptoms, and maybe medication that you might be taking other than peptides and could be helping, including RAPA.
I’ve had chronic lower back pain since childhood, and about 4-5 years ago it almost disappeared, and I have absolutely no clue why. What the heck I’ll join the fake euphoria train and say peptides saved my life and fixed my back LOL (oh wait it happen at least couple years before I even heard the word peptide).
There could be subtle positive effect that one might derive from peptides but the supposed effect that peptides helped one recover, or fixed an injury etc. are all false. I had an injury (still do to a degree) on my left knee and tried every single one of the peptides supposed to help including injecting directly into the area of injury and nothing helped at all, not even a damn placebo effect. What has helped and this is beyond my imagination is Eclomiphene as my knee felt better literally within a day of started Enclo. don’t know if there is any mechanism by which this is supposed to happen, but it can’t be placebo because I never expected such effect. It could however be coincidence as the body might be in a state in which it is healing itself better/faster and so it happened at same time as Enclo.
I hope you don’t take it the wrong way, but I am almost 100% certain that if you stopped all peptides cold turkey tomorrow morning you will not feel a difference. I have great respect for you, and I’m really glad your knee is better, but I think you’d save a bunch if you stopped peptides right away and with no ill effects. Peptides are not new even though the euphoria has swept in last five years or so, and there isn’t one reputable study to justify the claims people make.
BTW, if you can find a study that shows peptides you were taking are effective for your condition, then I’m willing to accept the claims (btw other than a Russian study LOl).
“I’ve had chronic lower back pain since childhood, and about 4-5 years ago it has almost disappeared, and I have absolutely no clue why.”
Yes, I have had long-term injuries that seemed to heal spontaneously. If I were a religious man, I might have invoked the power of prayer.
“What has helped and this is beyond my imagination is clomiphene as my knee felt better literally within a day of started Enclo.”
Testosterone has well-known analgesic properties.
“BTW, if you can find a study that shows peptides you were taking are effective for your condition, then I’m willing to accept the claims (btw other than a Russian study LOl).”
The research is ongoing, and many peptides–at least a dozen–have well-established therapeutic value. I don’t know how you can see the stunning effects of insulin, the GLPs, and SS-31 and still be dismissive of the whole category. People may be overreaching, but many more medical miracles are waiting to be discovered. I’m happoy to be a test subject.
“I hope you don’t take it the wrong way”
Not at all. You wear your skepticism well.
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I’ve tried many peps and ultimately only found a few to be impactful personally. Though I suspect some that didn’t have measurable impact randomly addressed issues that I did not have (e.g., mitochondrial health for MOTS-c, SS-31).
Tried and measurable positive impact apparent:
Sema, Rurz, Reta - scale and several labs
Tesa / Ipa - increased IGF-1 and z-score at dose dependent changes. Also FDA approved for limited use case.
Semax - internal dosing, noticeable impact though relatively short impact
Tried and found no or poor impacts per labs:
TA1 - maybe it helped with avoiding a cold my family members got, maybe it did nothing and I was just lucky? This one is marginal but possibly impactful.
TB4
BPC
GHK-cu - maybe some skin improvement, but not for loose skin or stretch marks. Measured significant copper serum increase.
Epithalon - didn’t measure telomere length
Thymulin
MOTS-C
SS-31
Ostarine - measurable change in labs and ‘feels’ but negative endocrine impact overall and required significant recovery to baseline time.
AOD - possibly had impact but hard to find source that doesn’t have reconstitution issues, consistent ISRs, and cannot distinguish impact from synchronously dosed Tirz.
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Interesting because I had identical experiences as you.
Semax did something small for me also and wouldn’t even mind continuing since it is dirt cheap, PT131 works for arousal almost as good as Cialis/Viagra, Tesa/ipa did same with me, increased IGF-1 but I didn’t want that affect, as I was already optimal.
GHK-cu, MotC, BPC and Tb500 Thymosin (the most revered ones) did absolutely nothing, zero, none for recovery or healing and that’s where my beef is with people who claim that these peps are miraculous, I can’t believe something that has absolutely no effect on one person will somehow end up being lifesaving for someone else. Look at lipid lowering drugs, or glucose lowering drugs as an example. One person my get a bigger impact but everyone gets some impact that’s why I call it BS when people say these were miraculous when in fact did nothing at all for me, now you, and I’ve heard similar experiences from other people also.
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I can’t claim these did nothing, I suspect TB4 and BPC had some positive impacts. But I did not measure these with range of motion or similar clinical measures and no known labs for these. Is my old shoulder injury better after these, yes, but was that just the passage of time, placebo, or some impact from the peps? Very hard to say.
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It is not progressing at this time. It seems quite stable and tolerable. I don’t take any pain meds. And only in my hands, not too much in the right hand.
It seems to me you mentioned something like 20 mg rapamycin + grapefruit juice one time. Is that the protocol you used for a while? If it is how long did you do it and how frequently? Maybe there’s something about a high dose for a short period of time that may give lasting benefits?
I did that a few times when I first started taking rapamycin, because I felt like I needed a major reset. The only side effect that I got from this was diarrhea the day after. I quit taking that high a dose since then.
Matt K is doing a live YouTube now on peptides.
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Kelman, you are too smart to be such a solipsist–a person holding the position that only his thoughts and experiences have objective reality. I hate to break it to you, buddy, but you are not the measure of all things.
Some people have allergic reactions to medications, while others do not. Some patients are more susceptible than others to entire classes of drugs. Because of things like genetics, diet, metabolism, etc., some have a lower or higher tolerance to all kinds of substances. Some meds–indeed, some foods-- have a toxic effect, and some have a null effect.
Likewise, anyone can have a reaction or a non-reaction to peptides.
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It just so happened you responded after this video from MK and surprise surprise he seems to have same opinion (as me) with regards to the most used ones BPC, TB-500 etc… So if they work for you just keep using them regardless of what I say, for me it is money down the drain. Sorry.
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Both TB-500 and BPC-57 have demonstrated regenerative properties across numerous animal models, which have not been replicated in human trials. Just like rapamycin, which is FDA-approved only for organ-transplant patients. It should get it at most a neutral smiley face for efficacy from Matt Kaeberlein.
And if the peptides are so unsafe, where are the bodies?
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New word of the day 
Though in the end I measure most things subjectively.
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No, I never claimed or said they are unsafe. Actually, I have consistently said I had no adverse effects from any I’ve tried, but my beef was I had a bad knee in desperate need of fixing and tried all the supposed ones that are mentioned for recovery and pains etc. and I got zero, zilch nothing. No benefit at all. I even injected in the knee area hoping it would help but still no help. That’s when i said these guys are all BS’ing. Now of course there is peptides that are FDA approved for various conditions including the ones for weight loss and they do work but I was talking about the ones that aren’t approved but have supposed anectodal stories of being miraculous for injury and pain but did not get any of that. BTW a lot of people now (including some docs in longevity) seem to have changed their mind a bit on peptides. Initially was like they are cure alls and now is more like well, most don’t do anything, it’s just hype. So, it is what it is, we are all different, if you feel you’re getting some benefit just keep doing it. For me no more peptides. I already wasted enough money on them. All my FDA approved meds (and off label used ones) I can tell I’m benefiting either by way of how I feel, or by improvements in biomarkers, so that’s where my money is and a few (about ten) suppliments
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I’ll grant you that. They ain’t cheap.
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