I had the same results with TA-1. A five-day cold instead of 10-14. What dose were you taking?
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Tim,
LL 37 (285mcg) + Ta-1 (855mcg) twice daily, morning and bedtime
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When I do high doses of Vit C and high doses of Lysine, a 14 day cold becomes ZERO day cold. It’s been this way for last 20+ years, no cold, no flu, no Sars, no covid.
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Have you seen this concerning ll37?
https://www.nature.com/articles/s41380-022-01790-6
In mouse and monkey models, LL-37 caused significant pathological phenotypes linked to AD, including elevated amyloid-β, increased neurofibrillary tangles, enhanced neuronal death and brain atrophy, enlargement of lateral ventricles, and impairment of synaptic plasticity and cognition, while Clic1 knockout and blockade of LL-37-CLIC1 interactions inhibited these phenotypes. Given AD’s association with infection and that overloading AMP may exacerbate AD, this study suggests that LL-37, which is up-regulated upon infection, may be a driving force behind AD by acting as an endogenous agonist of CLIC1.
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- I’m neither a mouse nor a monkey
- Every AD drug that worked in mice failed in humans
- I’d take a look monkeys as there is some evidence that some other primate species can exhibit dementia type responses as they age.Even though they are not taking LL 37
Since I use it sporadically and for short periods of time, I’m not very concerned as it takes more than 1 thing to cause dementia.
Some of the infections linked to Alzheimer’s include herpes, pneumonia, syphilis, Lyme disease and gum disease. There has also been links between Alzheimer’s disease and other infections that cause a long-term activation of the immune system.
So the fact that LL 37 can kill a wide variety of pathogens, bacteria, viri and fungus, I’m willing to take that risk by reducing my pathogen load
Plus I don’t have the AD genes so I’m at very low risk.
On top of that I’d guess that my inflammatory situation is reasonably low compared to those who don’t do what I do.
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Or perhaps the up regulation of LL 37 is how the system is fighting whatever is causing AD,
May be… just like the Tau theory.
https://www.science.org/content/blog-post/faked-beta-amyloid-data-what-does-it-mean
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Thanks for the detailed response. I’m not familiar with LL37 at all, and the alzheimer link caught my eye.
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Fisher1, how much is your high dose vitamin C and lysine?
I don’t do it every day, but only when it is the flu season. My maintenance during flu season (Nov-April) is 2000MG of each in the morning and same at night. Sometimes a may even skip the night one. If for any reason I feel I might be getting the flu or cold (rarely happens i think 2-3 times in last 20 years) I up the dose to 3000mg of each three times per day (for about a week), the symptoms literally disappear the next day or two. Then I’d go back to maintenance dose.
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I used to take 10,000mg Vit-C per day in 2 doses. Did that for over 20 years before I cut it down to 1000mg per day about 4 years ago.
Still got colds and the flu but I never took Lysine as a supplement as I was eating lots of food that is high in Lysine as well as in the whey protein I’ve been consuming for the past 20 years.
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This is of course anecdotal and n=1 but it is my experience that supplements/nutrients gotten from foods NEVER have the same effect as same supplements taken specifically for a purpose/condition. This has clearly been the case with Vit C and lysine (always combined, either alone did absolutely nothing btw) but I can attest to this with many other supplements, one being taurine, and the other arginine and few others. As an example, I’ve had acid reflux issues for as long as I can remember and I usually love steak (and other protein, lamb, chicken, wild caught fish) which has a lot of Taurine in it, yet the condition has never gotten better in spite of my high protein diet. The minute i started Taurine 2000mg in the morning (about 3 months ago) my condition literally has disappeared to never (so far) appear again. Same with Arginine. Even though as mentioned I consume a high protein diet which obviously has a lot of Arginine in it, I never get any specific effects as I do from supplement Arginine. I take 3000mg most times one hour before gym and not only seems to help with endurance and weights, but my veins look as if they want to explode. Many times, I go to gym about 1 hour after my dinner which is usually a 14 OZ steak with veggies or similar protein and there absolutely no veins you could see or any help whatsoever (no Arginine days) with weights or the endurance, just normal.
It is a simple guess of mine but looking at it pragmatically I think that the reason is because with food you get 100’s of other nutrients/supplements and they either cancel (to some degree each other) or fight for same mechanisms of action that blunts the effects of a specific nutrient. This is not to say that the best way to get nutrients is indeed through a balanced diet generally speaking, but it has been my experience that getting supplements through food has had ZERO therapeutic effect for any condition whatsoever.
Long story short yes Vitamin C combined with Lysine will actually help with the common cold or flu but only if taken in high doses and in combination, either alone does nothing (from my experience). It’s very easy to prove it, next time you have the symptoms of a cold or a flu (the first day you get them btw, not after five days lol) do 3000mg of both three times per day for 3-5 days only. It has worked 100% of the time for me, and couple other people I have suggested it to. btw, I know a couple of doctors that back this up and suggest it to all their patient, one being in Toronto (since you are Canadian lol) another one in Atlanta, and I think a doc somewhere in CO, could be more but these ones I’ve seen/heard them recommend same.
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Everything you ever wanted to know about GLP1’s, from the horses mouth.
Welcome to glucagon.com: a webpage devoted to the study of the glucagon-like peptides, and homepage of the Drucker Lab at Toronto’s Lunenfeld-Tanenbaum Research Institute (LTRI), Mount Sinai Hospital, directly adjacent to the University of Toronto campus.
Our laboratory carries out studies of the physiology of gut peptides, encompassing the mechanisms controlling their bioactivity, with a focus on glucagon and the glucagon-like peptides and their receptors. The laboratory is comprised of research technicians, research associates, and research fellows appointed to the Department of Medicine at the University of Toronto. Explore our recent research, publications and research reagents here.
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