I took only one round, and the doc doesn’t know. I think bioregulators are a scam. Meanwhile, my vision has been stable at all of my biannual visits, both before and after Visoluten.
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Peptide Update
For me, TB Frag (1-4) is more effective than TB-500, the final seven-AA sequence, and more effective than the full 43-AA peptide. Dosing Frag (1-4) at 500 mcg per day keeps me pain free for a month, and then I cycle off for a month, during which the pain relief continues.
500-mg capsules of BPC-157, ordered from SwissChems, have done nothing for me. Maybe they were on-sale for a reason.
EOD injections of a TB/BPC/GHK-cu combo work well for me. I was lucky to buy several kits when the price was low.
Semak spikes my blood pressure by 15-20 points.
I have found that, at daily intranasal doses of 300 mcg, selank and epitalon do have cognitive benefits. But I still do stupid things.
I have bone-on-bone osteo in the knee, but it doesn’t hurt. The Mayo Clinic says that this is not unusual. Nevertheless, I frequently, almost daily, inject AOD-9604 into the sub-patellar space, trying to extend my staying power.
Today, I pulled a muscle and came up gimpy. Nothing makes you injury free.
When I was in the martial arts, I routinely went home from sparring with serious lumps and bruises. But I always had a secret sauce, a miracle in a bottle. Back then, I could buy Dit Da Jow, an amazing herbal analgesic, in Chinatown or at any martial arts store worthy of the name. The Dit Da Jow I’ve gotten from Amazon is nowhere near the same.
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This is injections, not oral correct?
Injections, yes. Unsuccessfully tried capsules of BPC-157.
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Has anyone found out what Klotho fragment Celia-health is selling-and are there any papers that show this fragment increases PF4? Even in a murine model?
From Keith in a different thread: (I am unable to share the link)
“Mystery solved, this product is not klotho protein. It is a small 33 amino acid peptide klotho fragment. Real a-klotho protein is 1,012 aminos. Which explains why the dose is not the same.”
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First of this week we started taking DSIP - delta sleep inducing peptide.
> Stage 3 NREM N3, slow-wave sleep (SWS), delta sleep, deep sleep 20 to 40 minutes
One of our clients has a watch that monitors sleep and his Delta sleep has increased from an average of 32 minutes to 51 minutes.
That was an interesting results so I’ve ordered 3 of those watches for myself, wife and 1 son 
The suggested dose range is 100mcg to 500mcg.
We started with a 200mcg dose for 2 nights, then 300mcg and then 400mcg. I don’t find any difference with a higher dose so last night went back down to 200mcg and seemed to get the same benefit.
We have both noticed a benefit. I typically get up once per night for a visit to the bat room usually around 4am. I’ve been finding that I don’t fully wake up during my excursion and I barely remember going back to sleep as it happens so quickly.
My wife is a light sleeper (mother of 4 - although our youngest is now 41 the old habits are hard to shake). She is noticing a similar effect, any time she wakes she finds she is back to sleep without any effort.
This is not at all like a “sleeping pill”, theoretically it only affects the duration of Delta sleep. A very important part of the sleep cycle. Neither of us have felt “groggy” in the morning but I do feel more rested. I’ve been dealing with chronic pain from a sciatic issue for 2 moths now and that was having a negative impact on my typical “I sleep like a stone” thing.
Now I’m back sleeping like a stone, maybe even better than that. The pain is still there but does not seem to have the same effect on my sleep.
I forgot to mention this one. Since losing 55lb 2 years ago, my hands have been cold almost all the time. Yesterday evening I noticed they were not cold and they haven’t been cold since I started DSIP. Granted it’s a lot warmer but my hands were cold all the time, not just when I was out doors but at work, at home, all the time.
May have a direct or indirect effect on body temperature and alleviating hypothermia.[21][22][23]
Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide that was first isolated from rabbit brain in 1977. It is known for its ability to promote sleep, particularly characterized by an increase in the delta rhythm of the EEG (electroencephalogram), which is associated with slow-wave sleep. DSIP is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
Here’s a more detailed look at DSIP:
Key Properties and Effects:
- Promotes sleep:
DSIP is known to induce sleep, particularly slow-wave sleep, in various animal models, including rabbits, mice, rats, and cats.
- Reduces motor activity:
When infused into the brain, DSIP can reduce motor activity in rabbits.
- Diurnal variation:
DSIP concentrations in the brain and plasma exhibit a diurnal variation, with lower levels in the morning and higher levels in the afternoon.
- Modulates hormone secretion:
DSIP may play a role in regulating the release of hormones like growth hormone and prolactin.
- Potential therapeutic uses:
Studies have explored DSIP’s potential in treating insomnia, pain, and withdrawal symptoms, though results have been inconsistent.
- Possible links to other conditions:
DSIP-like immunoreactivity has been studied in relation to major depressive disorder, Cushing’s syndrome, and Alzheimer’s disease.
Mechanism of Action:
- Hypothalamus and brainstem:
DSIP is synthesized in the hypothalamus and targets multiple sites, including the brainstem.
- HPA axis:
DSIP is believed to influence the hypothalamus-pituitary-adrenal (HPA) axis, which is involved in stress response.
- Modulation of neurotransmitters:
DSIP may modulate neurotransmitter systems, potentially impacting sleep and other functions.
- Potential role in other pathways:
DSIP may also be involved in pathways like the MAPK and PI3K/AKT pathways, as well as interacting with the glucocorticoid-induced leucine zipper (GILZ).
Current Research:
- Ongoing research:
While DSIP has been studied for many years, its precise role in sleep regulation and other physiological processes is still not fully understood.
- Conflicting results:
Studies on DSIP’s effects on sleep have produced somewhat inconsistent results, and further research is needed to clarify its role.
- Potential for new treatments:
Despite the inconsistencies, DSIP’s potential in treating sleep disorders and other conditions continues to be explored.
In summary, Delta Sleep-Inducing Peptide is a neuropeptide that plays a role in regulating sleep and potentially other physiological processes. While its exact mechanisms and clinical applications are still under investigation, it remains a focus of research in the fields of sleep, neurobiology, and potential therapeutic interventions.
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I never did notice any sleep changes on dsip, but epitalon worked great for me. I made my own nasal spray with both, and stayed around the 200 to 400 mcg dosage for both. These days, I’m having improved sleep on gh secretagogues, but the dsip and epitalon stack for improved sleep is something I want to revisit when I can.
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Same here. Epitalon spray is a great sleep inducer and enhancer. Plus, it seems to have cognitive benefits.
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Where do you guys buy your epithalon nasal spray? Do you have a link?
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Hi Steve,
Any advice on a good international supplier, to Australia, of DSIP and Epithalon?
Much appreciated!
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I don’t know of any.
Lance Hitchings Peptides 101 course.
Good resources and it’s free.
He put together a longevity peptide toolkit which lists out all the peptides, their purpose, dosing, how to reconstitute, timing, frequency and more
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I’ve been using DSIP (delta sleep inducing peptide) for about 3 weeks now.
It has significantly increased my deep sleep from about 1.5 hr per night before, to 2+ hr’s a night.
It has also significantly increased my morning HRV from a average of 50 to 58 in the same time frame.
This one is now part of my peptide routine.
Several of my local test subjects have experienced the same thing. To be clear, this is NOT like a sleeping pill, with respect to sleep it seems to only affect deep sleep and maybe REM time, It does not make you sleepy or drowsy upon waking.
There are some other potential benefits to this one.
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I’ve continued to use LL 37 and Ta-1 when I get a cold or the flu, which is not very often, previous to the one I got last week I think it was close to a year with out anything like that.
I have taken this combo as a prophylactic in the hope it might kill some of those “resident” viri, and other pathogens that take up residence and modify our immune systems to hide until they cause late life issues related to various dementia’s.
Sunday June 29 I felt a cold coming on, a bit of sinus action. Monday morning I woke up with a full on sore throat, head banging cold. I mixed up a batch of LL 37 (285mcg) + Ta-1 (855mcg) and took the first dose Monday around noon, took a second dose at bed time, So doubling up as Monday night was not good and I want this gone ASAP
I double dosed morning and night Monday to Friday. basically the cold was gone Thursday but I wanted it to stay gone.
This combo at this dose shortened my typical cold duration from 10 to 14 days down to 5 days.
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The only international suppliers you’ll find are from China. Some of them have warehouses in various places i.e. USA and EU, don’t know about Australia.
This one @micrayray (her telegram handle) from SSA has been pretty good for me in last year or so. I’ve ordered peps from her few times and all successful. There are plenty others, but you’ll have to spend some time searching the web, mainly on forums @ Reddit. Just search “Peptide supplier for Australia” and you must get some help that way (if the one i gave you doesn’t work for Australia).
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This guy is in really good shape for 75. He must be doing something right.
Btw, do you have a printable/readable copy of the chart “The Longevity Peptide Toolkit”? Can’t read it…
Thanks,
I’ll have to come back to dsip some other time. I usually top out to just under 2 hours of deep sleep on a good night. Are there any stats on what a good amount of deep sleep is? Do you find that you actually sleep less on nights where your deep sleep goes over 2 hours? For me it’s often the case that when I get close to 2 hours of deep sleep, my total sleeping time is about 6 hours or less.
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I never tracked my sleep previous to using DSIP. I did track it for a few nights before I started.
I started at 200mcg DSIP and went up 100mcg per night to 500mcg to evaluate dose. I’ve settled on 300mcg as my sweet spot.
I only had 2 data points before I started DSIP 1:30 and 1:45 of Deep Sleep
For the past week;
- Average sleep score is 90
- Avg sleep time is 8:27
- Avg deep sleep is 1:45
- Peak deep sleep was 2:23
- Avg REM 1:04
My total sleep time does not seem to deviate if my DS is high or lower.
I’m using an AmazFit Bip 5 watch now. I started with a $48 watch to see if I’d be OK wearing it and I am, so I upgraded a bit
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