Also makes you nauseous and horny! It wouldn’t be my first choice of meds to combine with tirz, but I guess more options aren’t a bad thing.
Bremalanotide/PT-141 also requires a once daily injection since half life is short, so this doesn’t seem like much of a practical solution for the average person.
Yep, that’s I what I thought was so funny about this stack. It’s used to raise libido.
I think.ñ pt-14 was in pill form in the study, so it will just be a daily pill that people take.
Thanks for the correction! I could have sworn it was a pill. Wishful thinking…
Why halt tirzepatide and then start another peptide just to get the same effect?
I assume to show that it is effective against weight regain induced by stopping tirzepatide.
Pt-141 is cheaper than tirzepatide, so if you can maintain most of your ideal weight while not having to pay for tirzepatide, you save money.
Early on peptide path, I “micro-dosed” PT141 in combination with our night time combo of Ipa+CJC did that for a couple months. That is a 5 night a week shot. We did that at bedtime and slept through the “side effects” that might be derived from PT141.
My interest in that little experiment was dopamine related.
It seemed to work but I may have had the dose a bit high for my intended purpose. It was 120mcg per dose. I think I’ll revisit that and use a 60mcg dose added to our nightly shot.
I looked back through my email with my supplier on this. I had asked for TB500 and the first question was, which “version” (there are 3 versions of TB500), I decided on the frag 1-4 version.
The real name is not TB500 it’s…
Goralatide, cas# 127103-11-1
I have it in vials of lyophilized powder, which I converted to an intranasal spray. The effects, including the side-effects, are increased.
Good to know! I didn’t realize there could be differences between delivery methods. One person told me that selank subq didn’t work for them, but was so much more effective in a spray. Just interesting.
This is fairly common with brain oriented drugs and peptides.
Also causes pedema and severe facial flushing. The flushing fades after a few hours, but the pedema, which interferes with running, endures for 24-36. Not a pleasant experience. I will titrate downward to find the lowest but still effective dose.
I was under the impression that growth hormone was antithetical to longevity? CJC and Ipamorelin are growth hormone releasing hormone peptides.
Yes and very effective for that purpose.
As far as the “longevity” aspect, there are many fish to fry in that ocean 
hGH and IGF-1 are both good and bad - at the same time… so pick your poison as they say. Yes there are large population studies indicating high IGF-1 is not good. As well as studies that indicate it’s beneficial for cognition as we age, as is hGH.
What is the balance between the benefits and drawbacks? each individual must weight those for any intervention they decide to use.
When there is a perfect path to maximum health span I’d use that algorithm. Maybe someday in the near future there will be an AI for that. I’d love to upload my DNA sequence, all my blood work and tests and have a better idea of how far I can push the limits of personal experimentation. In the meantime I have to be my own personal AI
With respect to “longevity” there is no way to extend human lifespan beyond 120, I’m not terribly worried about trying to do something that is impossible so I focus on things that may increase my health span.
Having a robust and effective immune system as we age is;
And that is why I like the idea of the TRIIM protocol, which requires hGH. hGH has been studied for this effect for over 20 years now. Thymic involution degrades the effectiveness of our immune system. hGH does reverse that.
So far, from what I’ve seen in my blood work, my immune system is excellent and for the past 18 months I’ve not had a cold or the flu or any sickness like that. And I get exposed, on a regular basis to my “sick” grand kids, sick work mates, sick friends. All of whom I can’t avoid.
Overall it’s pretty awesome being as healthy as I’m fortunate to be, same for my wife.
What makes going beyond 120 impossible to you given we don’t know what the future holds?
TRIIM protocol sounds interesting I have heard about this one. I’ve been looking into thymus regeneration myself. Tried out some TB500, is that any good for this?
The elastin problem is what limits the max human life span to 120. It is a “hard stop” and today there is no solution to that problem and there will not be a solution in my life time.
It’s extremely complex but well researched and very well understood as to what elastin is and what it does. The fix on the other hand is 30+ years away, IMHO.
It’s actually more difficult that solving “cancer”, when do you see cancer being solved? sure treated but solved??? There are a few vaccines for specific cancers that are tremendously successful but they don’t “solve” all cancers.
Look up elastin on the forum, I’ve posted on this quite a bit
TB500 is not going to restore the thymus.
The thymus generates 3 Thymulin hormones
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/thymus-hormone
Also there is a lot of confusion on what TB500 is. It’s actually a sub set of Thymosin Beta-4. There are 3 “versions” avalable. I’ve posted an extensive review of that in this thread.
Depending on the source, you might not be getting what you think you are getting
I had been using Gonarorelin and after a 5 months there was a measurable increase in my testosterone. A month ago I switched to Kisspeptin 10 to check that one out. No ill effects so I decided to combine those 2 in one vial (I will take this 2 times per day, morning and night) for 6 weeks and a break of 1 week and go again.
They both provide a boost in test through different pathways.
https://www.differencebetween.com/what-is-the-difference-between-kisspeptin-10-and-gonadorelin/
I came up with a “catchy” name for this combo LoL!
KGB (Kis+Gon+B@lls)
I know, kinda crude but it made the wife laugh Since the doses are low, it’s quite cost effective.
I’m looking forward to my next test - test
Maybe you’ve answered this elsewhere, but have you tried this peptide? I’ve heard about it, but I didn’t connect it to Stealth Bio. I just know it as SS 31.
I have not tried it yet and it’s on the list for my next order. In about a month I should have it in.
I have used MOTS-c, a mitochondrial “derived” peptide. Did not notice a big difference but I may have had my dose too low and timing may be more important than I thought.
